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    CNN1 calponin 1 [ Homo sapiens (human) ]

    Gene ID: 1264, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Long non-coding RNA MEG3 acts as a suppressor in breast cancer by regulating miR-330/CNN1.

    Long non-coding RNA MEG3 acts as a suppressor in breast cancer by regulating miR-330/CNN1.
    Yi D, Wang Z, Yang H, Wang R, Shi X, Liu Z, Xu F, Lu Q, Chu X, Sang J., Free PMC Article

    02/6/2024
    Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens.

    Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens.
    Wong NACS, Beavers S, Gill P, Heryet A, Linares J.

    02/12/2022
    Studied maternal serum calponin 1 levels in the prediction of delivery within 7 days among pregnancies complicated with threatened preterm labor. Of 73 women included in the study, found the maternal serum calponin 1 level was significantly high in women who delivered within 7 days vs. those who delivered after 7 days.

    Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor.
    Cetin O, Karaman E, Boza B, Cim N, Sahin HG.

    12/2/2017
    Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 in adjacent tumor cells.

    Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.
    Russell TD, Jindal S, Agunbiade S, Gao D, Troxell M, Borges VF, Schedin P., Free PMC Article

    06/4/2016
    Loss of CNN1 expression is associated with Ovarian Cancer.

    Identification of the Critical Site of Calponin 1 for Suppression of Ovarian Cancer Properties.
    Yamane T, Asanoma K, Kobayashi H, Liu G, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K.

    02/20/2016
    CNN1 immunohistochemical staining allows ready recognition of intracytoplasmic inclusions, aiding diagnosis of infantile digital fibromatosis.

    Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis.
    Henderson H, Peng YJ, Salter DM.

    05/16/2015
    epsilonPKC/ERK/mTOR pathway activation induced by the rescued expression of CNN1 contributed to the improvement of cardiac dysfunction and pathological changes observed in transgenic mice.

    Calponin1 inhibits dilated cardiomyopathy development in mice through the εPKC pathway.
    Lu D, Zhang L, Bao D, Lu Y, Zhang X, Liu N, Ge W, Gao X, Li H, Zhang L.

    12/20/2014
    Calponin knockdown inhibits autophosphorylation.

    Regulation of PKC autophosphorylation by calponin in contractile vascular smooth muscle tissue.
    Kim HR, Gallant C, Morgan KG., Free PMC Article

    08/16/2014
    Expression of transforming growth factor-beta (4.3 +/- 1.4 vs 2.6 +/- 2.3, p = 0.01) and calponin (3.7 +/- 0.7 vs 0.6 +/- 1.1, p = 0.05) was lower from infants with vs without a PDA.

    Hypertensive changes within the aortic arch of infants and children with isolated coarctation.
    Swartz MF, Morrow D, Atallah-Yunes N, Cholette JM, Gensini F, Kavey RE, Alfieris GM.

    09/7/2013
    Calponin-1 expression in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues was significantly different.

    [Expression of Calponin-1 and Transgelin in human uterine smooth muscles in non-labor and labor situation].
    Chen Q, Gu Y, Zhou C, Hu L, Peng C.

    12/3/2011
    Inhibition of calponin-1 expression can inhibit uterine smooth muscle cell migration and cause the morphological change and rearrangement of F-actin without affecting its proliferation and apoptosis in vitro.

    [Effects of calponin-1 gene silencing on the biological behavior of uterine smooth muscle cells].
    Gu YH, Zhou CJ, Hu LY, Chen Q, Zhang WS.

    11/26/2011
    A single intronic CArG element is necessary but insufficient for proper CNN1 expression in vivo. CNN1 overexpression antagonizes arterial injury-induced neointimal formation.

    Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation.
    Long X, Slivano OJ, Cowan SL, Georger MA, Lee TH, Miano JM., Free PMC Article

    11/12/2011
    D2-40 immunohistochemistry reliably identifies the myoepithelial cells of breast in a variety of lesions in a pattern similar to that of calponin and p63.

    D2-40: an additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion.
    Ren S, Abuel-Haija M, Khurana JS, Zhang X., Free PMC Article

    06/18/2011
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article

    09/15/2010
    The point mutation S175T exhibited more resistance to actin rearrangement by cytochalasin D and PDBu than intact CNh1, suppressing cell motility induced by PDBu.

    Calponin h1-S175T point mutation enhances resistance to actin cytoskeleton perturbation in human cancer cells.
    Sugaya A, Takeoka M, Itano N, Taguchi A, Ehara T, Taniguchi S.

    07/5/2010
    Calponin and alpha-inhibin are the most useful positive markers for serous microcystic adenoma, and are negative in most entities in the differential diagnosis.

    Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors.
    Marsh WL, Colonna J, Yearsley M, Bloomston M, Frankel WL.

    01/21/2010
    expression of vascular CNN1 in the peripheral region of colon cancer tissues was significantly reduced in association with tumor progression, lymphatic invasion, vascular invasion and recurrence.

    Reduction of Calponin h1 expression in human colon cancer blood vessels.
    Yanagisawa Y, Takeoka M, Ehara T, Itano N, Miyagawa S, Taniguchi S.

    01/21/2010
    the calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes

    The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes.
    Zhou Z, Yin J, Dou Z, Tang J, Zhang C, Cao Y.

    01/21/2010
    analysis of distinct sites of interaction that form the calponin: gelsolin complex and two calcium switches that control its activity

    Two distinct sites of interaction form the calponin: gelsolin complex and two calcium switches control its activity.
    Ferjani I, Fattoum A, Maciver SK, Manai M, Benyamin Y, Roustan C.

    01/21/2010
    results suggest that regulation of h1-calponin is involved in the regulation of differentiation of AR42J cells into insulin-producing cells

    Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells.
    Morioka T, Koyama H, Yamamura H, Tanaka S, Fukumoto S, Emoto M, Mizuguchi H, Hayakawa T, Kojima I, Takahashi K, Nishizawa Y.

    01/21/2010
    expression in tumor vessels is a new and useful means to predict prognosis of hepatocellular carcinoma after hepatic resection

    Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis.
    Sasaki Y, Yamamura H, Kawakami Y, Yamada T, Hiratsuka M, Kameyama M, Ohigashi H, Ishikawa O, Imaoka S, Ishiguro S, Takahashi K.

    01/21/2010
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