| Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy. | Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
Miao Y, Zhong Y, Li Y, Qin H, Yang L, Cao G, Tang Y, Yu T, Fan D, Lu Y, Peng J, Huang K. | 05/28/2024 |
| HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture. | HSPB6 Deficiency Promotes the Development of Aortic Dissection and Rupture.
Gao S, Zhang K, Zhou C, Song J, Gu Y, Cao F, Wang J, Xie E, Yu C, Qiu J. | 03/25/2024 |
| Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway. | Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway.
Guo L, Xiao K, Xie Y, Yang Z, Lei J, Cai L., Free PMC Article | 12/23/2023 |
| Cellular functions of heat shock protein 20 (HSPB6) in cancer: A review. | Cellular functions of heat shock protein 20 (HSPB6) in cancer: A review.
Wu Y, Zhao J, Tian Y, Jin H. | 11/3/2023 |
| HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is Induced by 5-aza-2'-Deoxycytidine In Vitro. | HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is Induced by 5-aza-2'-Deoxycytidine In Vitro.
Almutairi BO, Almutairi MH, Alrefaei AF, Alkahtani S, Alarifi S., Free PMC Article | 08/23/2023 |
| Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry. | Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry.
Pfeffer TJ, Auber B, Pabst B, Agca KC, Berliner D, König T, Hilfiker-Kleiner D, Bauersachs J, Ricke-Hoch M. | 04/12/2023 |
| Physico-chemical properties of two point mutants of small heat shock protein HspB6 (Hsp20) with abrogated cardioprotection. | Physico-chemical properties of two point mutants of small heat shock protein HspB6 (Hsp20) with abrogated cardioprotection.
Shatov VM, Gusev NB. | 01/16/2021 |
| Effect of Arginine on Chaperone-Like Activity of HspB6 and Monomeric 14-3-3zeta. | Effect of Arginine on Chaperone-Like Activity of HspB6 and Monomeric 14-3-3ζ.
Mikhaylova VV, Eronina TB, Chebotareva NA, Shubin VV, Kalacheva DI, Kurganov BI., Free PMC Article | 12/19/2020 |
| HSP20 affects the invasiveness of extravillous trophoblast cells via Akt signaling pathway, and the its dysregulation might contribute to the pathophysiology of pre-eclampsia. | HSP20 Exerts a Protective Effect on Preeclampsia by Regulating Function of Trophoblast Cells Via Akt Pathways.
Li F, Xie Y, Wu Y, He M, Yang M, Fan Y, Li X, Qiao F, Deng D. | 04/18/2020 |
| these findings reveal a new regulatory mechanism of HSPB6 in cell survival through its interaction with BECN1. | Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6(S10F) mutant.
Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC, Kranias EG., Free PMC Article | 03/2/2019 |
| Structural basis for the interaction of a human HSPB6 protein with the 14-3-3 universal signaling regulator has been reported. | Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Sluchanko NN, Beelen S, Kulikova AA, Weeks SD, Antson AA, Gusev NB, Strelkov SV., Free PMC Article | 10/7/2017 |
| Data suggest that HSPB6 forms hetero-oligomers with HSPB1 under the following rules: (1) highly conserved motif RLFDQXFG is necessary for subunit exchange among oligomers, (2) a site about 20 residues downstream of this motif determines size of resultant hetero-oligomers, and (3) a region in the N-terminal domain that is unique to HSPB6 dictates preferential formation of heterodimers. (HSP = heat shock protein) | Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1.
Heirbaut M, Lermyte F, Martin EM, Beelen S, Sobott F, Strelkov SV, Weeks SD., Free PMC Article | 07/8/2017 |
| findings strongly suggest that phosphorylated HSP20 inhibits TGF-alpha-induced HCC cell migration and invasion via suppression of the JNK signaling pathway | Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-α-Induced Migration and Invasion of Hepatocellular Carcinoma Cells.
Matsushima-Nishiwaki R, Toyoda H, Nagasawa T, Yasuda E, Chiba N, Okuda S, Maeda A, Kaneoka Y, Kumada T, Kozawa O., Free PMC Article | 08/13/2016 |
| multiple sclerosis lesions revealed exclusive induction of HSPB6 in astrocytes, as confirmed by co-localization of HSPB6 with GFAP. | Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter.
Peferoen LA, Gerritsen WH, Breur M, Ummenthum KM, Peferoen-Baert RM, van der Valk P, van Noort JM, Amor S., Free PMC Article | 05/28/2016 |
| N-terminal mutations increase stability of large HspB1 homooligomers, prevent their phosphorylation-dependent dissociation, modulate their interaction with HspB6 and decrease their chaperoning capacity, preventing normal functioning of HspB1. | Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases.
Muranova LK, Weeks SD, Strelkov SV, Gusev NB., Free PMC Article | 02/6/2016 |
| Findings strongly suggest that HSP20 directly associates with Bax and stimulates caspase cascade in human hepatocellular carcinoma cells. | Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax.
Nagasawa T, Matsushima-Nishiwaki R, Toyoda H, Matsuura J, Kumada T, Kozawa O. | 11/7/2015 |
| Data suggest that heat shock protein 20 (HSP20) may have value as a prognostic tumor marker and its overexpression might be a novel strategy for colorectal cancer (CRC) therapy. | Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis.
Ju YT, Kwag SJ, Park HJ, Jung EJ, Jeong CY, Jeong SH, Lee YJ, Choi SK, Kang KR, Hah YS, Hong SC. | 08/22/2015 |
| peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to alpha-crystallin also have robust chaperone and anti-apoptotic activities. | Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities.
Nahomi RB, DiMauro MA, Wang B, Nagaraj RH., Free PMC Article | 04/18/2015 |
| These findings strongly suggest that HSP20 might decrease the IKK-alpha protein level and that it down-regulates the TNF-alpha-stimulated intracellular signaling in HCC, thus resulting in the suppression of HCC progression. | Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
Nagasawa T, Matsushima-Nishiwaki R, Yasuda E, Matsuura J, Toyoda H, Kaneoka Y, Kumada T, Kozawa O. | 03/21/2015 |
| HSP20 may play a protective role against the progression of ovarian cancer. | Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer.
Qiao N, Zhu Y, Li H, Qu Z, Xiao Z. | 01/3/2015 |
| HSP20 directly associates with PI3K subunits and suppresses its activity in hepatocellular carcinoma, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of hepatocellular carcinoma. | Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.
Matsushima-Nishiwaki R, Kumada T, Nagasawa T, Suzuki M, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Toyoda H, Kozawa O., Free PMC Article | 08/9/2014 |
| 14-3-3zeta and possibly other 14-3-3 isoforms may have additional functional roles conducted by the monomeric state | Monomeric 14-3-3ζ has a chaperone-like activity and is stabilized by phosphorylated HspB6.
Sluchanko NN, Artemova NV, Sudnitsyna MV, Safenkova IV, Antson AA, Levitsky DI, Gusev NB., Free PMC Article | 12/8/2012 |
| the cytosolic protein AKAP-Lbc (AKAP13) as the anchoring protein responsible for directing PKA phosphorylation of Hsp20 on Ser(16) | The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).
Edwards HV, Scott JD, Baillie GS., Free PMC Article | 11/17/2012 |
| Hsp20 serves as a novel cardiokine in regulating myocardial angiogenesis through activation of the VEGFR signaling cascade. | Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.
Zhang X, Wang X, Zhu H, Kranias EG, Tang Y, Peng T, Chang J, Fan GC., Free PMC Article | 08/25/2012 |
| cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 | Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Sudnitsyna MV, Seit-Nebi AS, Gusev NB. | 06/23/2012 |