| LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis. | LncRNA TUG1 Exacerbates Myocardial Fibrosis in Diabetic Cardiomyopathy by Modulating the microRNA-145a-5p/Cfl2 Axis.
Wang K, Lin Y, Shen H, Yu S, Xu J. | 03/11/2023 |
| Role of MiR-325-3p in the Regulation of CFL2 and Myogenic Differentiation of C2C12 Myoblasts. | Role of MiR-325-3p in the Regulation of CFL2 and Myogenic Differentiation of C2C12 Myoblasts.
Nguyen MT, Lee W., Free PMC Article | 12/4/2021 |
| Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype. | Knockin mouse model of the human CFL2 p.A35T mutation results in a unique splicing defect and severe myopathy phenotype.
Rosen SM, Joshi M, Hitt T, Beggs AH, Agrawal PB., Free PMC Article | 08/28/2021 |
| CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts. | CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts.
Nguyen MT, Min KH, Kim D, Park SY, Lee W. | 03/20/2021 |
| Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage. | ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.
Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F., Free PMC Article | 03/28/2020 |
| Results provide strong evidence that muscle-type cofilin (or cofilin-2) plays a critical role in the formation and the maintenance of myofibril structure not only in skeletal muscle but also in cardiac muscle. | Chimeric Mice with Deletion of Cfl2 that Encodes Muscle-Type Cofilin (MCF or Cofilin-2) Results in Defects of Striated Muscles, Both Skeletal and Cardiac Muscles.
Mohri K, Suzuki-Toyota F, Obinata T, Sato N. | 06/8/2019 |
| These results indicated that the mouse CFL2 gene may be involved in the regulation of MyHC via the key signaling molecules of CFL2-related signaling pathways. | Role of the cofilin 2 gene in regulating the myosin heavy chain genes in mouse myoblast C2C12 cells.
Zhu H, Yang H, Zhao S, Zhang J, Liu D, Tian Y, Shen Z, Su Y. | 07/21/2018 |
| miR-301a regulates Cofilin-2 in vitro in NRVCM, and in vivo in Cs1-ko mice. Our findings provide an additional and important layer of Cfl2 regulation, which we believe has an extended role in cardiac signal transduction and dilated cardiomyopathy presumably due to the reported involvement of Cfl2 in these mechanisms. | MicroRNA miR-301a is a novel cardiac regulator of Cofilin-2.
Rangrez AY, Hoppe P, Kuhn C, Zille E, Frank J, Frey N, Frank D., Free PMC Article | 11/4/2017 |
| Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin dephosphorylation, plays a critical role in the development of atherosclerotic lesions. | P2Y(12) Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis.
Niu X, Pi SL, Baral S, Xia YP, He QW, Li YN, Jin HJ, Li M, Wang MD, Mao L, Hu B. | 06/24/2017 |
| deficiency of cofilin-2 is associated with interruption of the cell cycle at several checkpoints, hindering muscle regeneration | Skeletal muscle microRNA and messenger RNA profiling in cofilin-2 deficient mice reveals cell cycle dysregulation hindering muscle regeneration.
Morton SU, Joshi M, Savic T, Beggs AH, Agrawal PB., Free PMC Article | 02/6/2016 |
| Levels of smooth muscle alpha-actin were increased and remained high in developing muscles, suggesting that cofilin2 plays a crucial role during the exchange of alpha-actin isoforms during the early postnatal remodeling of the sarcomere. | Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance.
Gurniak CB, Chevessier F, Jokwitz M, Jönsson F, Perlas E, Richter H, Matern G, Boyl PP, Chaponnier C, Fürst D, Schröder R, Witke W. | 05/16/2015 |
| cofilin-2, although not critical for muscle development, is essential for muscle maintenance. | Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance.
Agrawal PB, Joshi M, Savic T, Chen Z, Beggs AH., Free PMC Article | 09/15/2012 |
| MLP binds directly to CFL2 in human cardiac and skeletal muscles. | Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.
Papalouka V, Arvanitis DA, Vafiadaki E, Mavroidis M, Papadodima SA, Spiliopoulou CA, Kremastinos DT, Kranias EG, Sanoudou D., Free PMC Article | 01/21/2010 |
| role of Cofilin-2 in actin dynamics | The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics.
Vartiainen MK, Mustonen T, Mattila PK, Ojala PJ, Thesleff I, Partanen J, Lappalainen P., Free PMC Article | 01/21/2010 |