| TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3. | TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3.
Wen J, Wang Q, Zhang W, Wang W. | 01/6/2024 |
| PLK3 promotes the proneural-mesenchymal transition in glioblastoma via transcriptional regulation of C5AR1. | PLK3 promotes the proneural-mesenchymal transition in glioblastoma via transcriptional regulation of C5AR1.
Yu S, Lv L, Li Y, Ning Q, Liu T, Hu T. | 09/27/2023 |
| Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile. | Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.
Deng S, Lu X, Zhang Z, Meng R, Li M, Xia S., Free PMC Article | 02/5/2022 |
| Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6. | Phosphorylation of PLK3 Is Controlled by Protein Phosphatase 6.
Aquino Perez C, Palek M, Stolarova L, von Morgen P, Macurek L., Free PMC Article | 04/3/2021 |
| The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3. | The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Vaughan CA, Singh S, Subler MA, Windle JJ, Inoue K, Fry EA, Pillappa R, Grossman SR, Windle B, Andrew Yeudall W, Deb SP, Deb S., Free PMC Article | 02/20/2021 |
| Those data indicate that the overexpression of PLK3-mediated degradation of abnormal PrP is largely dependent on chaperone-mediated autophagy pathway. | Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Wang H, Tian C, Sun J, Chen LN, Lv Y, Yang XD, Xiao K, Wang J, Chen C, Shi Q, Shao QX, Dong XP. | 05/12/2018 |
| Data indicate that elevated levels of Polo-like kinase 3 (Plk3)and pT273 caspase-8 are correlated with favorable clinical outcome in patients with anal squamous cell carcinoma (anal SCC) treated with concomitant chemoradiotherapy (CRT). | Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
Rödel F, Martin D, Helmke C, Balermpas P, Fokas E, Wieland U, Rave-Fränk M, Kitz J, Matthess Y, Raab M, Strebhardt K, Rödel C., Free PMC Article | 02/3/2018 |
| Knockout (KO) or knockdown of caspase-8, CD95 or FADD prevents activation of Plk3 upon CD95 stimulation, suggesting a requirement of a functional death-inducing signaling complex for Plk3 activation. | Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.
Helmke C, Raab M, Rödel F, Matthess Y, Oellerich T, Mandal R, Sanhaji M, Urlaub H, Rödel C, Becker S, Strebhardt K., Free PMC Article | 12/16/2017 |
| study revealed an interesting mutual regulation between Plk3 and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response. | Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
Li C, Park S, Zhang X, Dai W, Xu D., Free PMC Article | 07/15/2017 |
| the differential effects of hypoxic stress on Plk3 activity in Human Limbal Stem and HCE cells. Instead of apoptosis, hypoxic stress suppresses Plk3 activity to protect limbal stem cells from death and to allow the process of Human Limbal Stem cell differentiation. | Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation.
Wang L, González S, Dai W, Deng S, Lu L., Free PMC Article | 05/7/2017 |
| Data suggest that HOXA-AS2 could be an oncogene for gastric cancer partly through suppressing P21, PLK3, and DDIT3 expression. | Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.
Xie M, Sun M, Zhu YN, Xia R, Liu YW, Ding J, Ma HW, He XZ, Zhang ZH, Liu ZJ, Liu XH, De W., Free PMC Article | 09/17/2016 |
| Plk3 is involved in the inhibition of cell proliferation and tumorigenesis, which may occur via interactions with p21. | Polo‑like kinase 3 inhibits osteosarcoma cell proliferation and tumorigenesis via cooperative interaction with p21.
Lv H, Gao G, Zhang L, Sun Y. | 08/27/2016 |
| PLK3 predominantly is expressed in Cholangiocarcinomas (CCA) cells and that high PLK3 expression correlates with prolonged overall survival. | Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma.
Juntermanns B, Sydor S, Kaiser GM, Jaradat D, Mertens JC, Sotiropoulos GC, Swoboda S, Neuhaus JP, Meng W, Mathé Z, Baba HA, Canbay A, Paul A, Fingas CD. | 08/6/2016 |
| The role of Plk3 in oncogenesis: the aberrant expression of Plk3 was found in different types of tumors. | The role of Plk3 in oncogenesis.
Helmke C, Becker S, Strebhardt K. | 05/28/2016 |
| hyperosmotic stress-activated Plk3 elicited gammaH2AX. | Osmotic stress-induced phosphorylation of H2AX by polo-like kinase 3 affects cell cycle progression in human corneal epithelial cells.
Wang L, Dai W, Lu L., Free PMC Article | 02/14/2015 |
| Plk3 binds to CtIP phosphorylated at S327 via its Polo box domains, which is necessary for robust damage-induced CtIP phosphorylation at S327 and subsequent CtIP phosphorylation at T847. | Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M., Free PMC Article | 11/29/2014 |
| have identified and validated as in vitro PLK2 and PLK3 substrates HSP90, GRP-94, beta-tubulin, calumenin, and 14-3-3 epsilon | Investigation on PLK2 and PLK3 substrate recognition.
Salvi M, Trashi E, Cozza G, Franchin C, Arrigoni G, Pinna LA. | 01/12/2013 |
| Here, the authors report phosphorylation of Thr4 by Polo-like kinase 3 in mammalian cells. | Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.
Hintermair C, Heidemann M, Koch F, Descostes N, Gut M, Gut I, Fenouil R, Ferrier P, Flatley A, Kremmer E, Chapman RD, Andrau JC, Eick D., Free PMC Article | 08/25/2012 |
| Bcl-xL phosphorylation at Ser49 by polo-like kinase 3 during cell cycle progression and checkpoints | Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.
Wang J, Beauchemin M, Bertrand R., Free PMC Article | 01/14/2012 |
| Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. | Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
Naik MU, Naik UP., Free PMC Article | 06/18/2011 |
| hyperosmotic stress can activate the Plk3 signaling pathway that subsequently regulates the AP-1 complex by directly phosphorylating ATF-2 independent from the effects of JNK and p38 activation. | Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.
Wang L, Payton R, Dai W, Lu L., Free PMC Article | 02/26/2011 |
| Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha | Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
Xu D, Yao Y, Lu L, Costa M, Dai W., Free PMC Article | 01/15/2011 |
| upregulation of CIB1 in cancer cells may inhibit Plk3 activity, leading to abnormal cell cycle regulation in breast cancer cells. | Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.
Naik MU, Pham NT, Beebe K, Dai W, Naik UP., Free PMC Article | 01/15/2011 |
| Plk3 as a new player in the regulation of the PI3K/PDK1/Akt signaling axis by phosphorylation and stabilization of PTEN. | Regulation of PTEN stability and activity by Plk3.
Xu D, Yao Y, Jiang X, Lu L, Dai W., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ., Free PMC Article | 06/30/2010 |