| A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27. | A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27.
Xu L, Zhang J, Li L, Wang P, Zheng X, Luo J, Zhang S, Li L, Yi P, Zhang Y, Yan T, Xie L, Feng L, Zhang M, Xu M. | 06/22/2023 |
| The expression of p27 in the adult vestibular sensory organs and its possible roles. | The expression of p27 in the adult vestibular sensory organs and its possible roles.
Huang Y, Zhou Q, Li W, Chen Y. | 02/28/2023 |
| p27[Kip1] Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. | p27(Kip1) Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice.
Colon-Mesa I, Sainz N, Corrales P, Collantes M, Kaldis P, Martinez JA, Medina-Gómez G, Moreno-Aliaga MJ, Escoté X., Free PMC Article | 02/16/2023 |
| The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2. | The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2.
Domingo-Muelas A, Morante-Redolat JM, Moncho-Amor V, Jordán-Pla A, Pérez-Villalba A, Carrillo-Barberà P, Belenguer G, Porlan E, Kirstein M, Bachs O, Ferrón SR, Lovell-Badge R, Fariñas I., Free PMC Article | 01/14/2023 |
| Inability to phosphorylate Y88 of p27(Kip1) enforces reduced p27 protein levels and accelerates leukemia progression. | Inability to phosphorylate Y88 of p27(Kip1) enforces reduced p27 protein levels and accelerates leukemia progression.
Jäkel H, Taschler M, Jung K, Weinl C, Pegka F, Kullmann MK, Podmirseg SR, Dutta S, Moser M, Hengst L., Free PMC Article | 07/9/2022 |
| Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic beta-Cell Proliferation Through the CPEB1/CDKN1B Pathway. | Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway.
Hu Q, Mu J, Liu Y, Yang Y, Liu Y, Pan Y, Zhang Y, Li L, Liu D, Chen J, Zhang F, Jin L. | 03/5/2022 |
| Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway. | Cyclin-dependent kinase inhibitor 1B acts as a novel molecule to mediate testosterone synthesis and secretion in mouse Leydig cells by luteinizing hormone (LH) signaling pathway.
Guo H, Luo X, Sun L, Li J, Cui S. | 01/29/2022 |
| Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity. | Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity.
Colón-Mesa I, Fernández-Galilea M, Sáinz N, Lopez-Yus M, Artigas JM, Arbonés-Mainar JM, Félix-Soriano E, Escoté X, Moreno-Aliaga MJ., Free PMC Article | 12/25/2021 |
| GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27(kip1). | GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27(kip1).
Xu J, Yu D, Dong X, Xie X, Xu M, Guo L, Huang L, Tang Q, Gan L., Free PMC Article | 11/27/2021 |
| Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4. | Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.
Choi SH, Barker EC, Gerber KJ, Letterio JJ, Kim BG., Free PMC Article | 08/7/2021 |
| Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity. | Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
Rai KR, Chen B, Zhao Z, Chen Y, Hu J, Liu S, Maarouf M, Li Y, Xiao M, Liao Y, Chen JL. | 07/31/2021 |
| The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma. | The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma.
Wang J, Aldahamsheh O, Ferrena A, Borjihan H, Singla A, Yaguare S, Singh S, Viscarret V, Tingling J, Zi X, Lo Y, Gorlick R, Zheng D, Schwartz EL, Zhao H, Yang R, Geller DS, Hoang BH., Free PMC Article | 05/29/2021 |
| Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration. | Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration.
Urun FR, Moore AW., Free PMC Article | 03/28/2021 |
| Depletion of cyclic-GMP levels and inhibition of cGMP-dependent protein kinase activate p21(Cip1) /p27(Kip1) pathways and lead to renal fibrosis and dysfunction. | Depletion of cyclic-GMP levels and inhibition of cGMP-dependent protein kinase activate p21(Cip1) /p27(Kip1) pathways and lead to renal fibrosis and dysfunction.
Das S, Neelamegam K, Peters WN, Periyasamy R, Pandey KN., Free PMC Article | 03/13/2021 |
| Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma. | Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma.
Chen X, Cates JMM, Du YC, Jain A, Jung SY, Li XN, Hicks JM, Man TK., Free PMC Article | 02/6/2021 |
| The Akt/FoxO/p27(Kip1) axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars. | The Akt/FoxO/p27(Kip1) axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars.
Yang F, Chen E, Yang Y, Han F, Han S, Wu G, Zhang M, Zhang J, Han J, Su L, Hu D., Free PMC Article | 09/5/2020 |
| Loss of p27(kip1) suppresses the myocardial senescence caused by estrogen deficiency. | Loss of p27(kip1) suppresses the myocardial senescence caused by estrogen deficiency.
Yan Y, Miao D, Yang Z, Zhang D. | 08/15/2020 |
| upregulated P27 participated in TGF-beta-mediated pulmonary fibrosis, and the expression of P27 in pulmonary fibrosis tissues was regulated by MTORC2 | P27 Promotes TGF-β-Mediated Pulmonary Fibrosis via Interacting with MTORC2.
Dai YH, Li XQ, Dong DP, Gu HB, Kong CY, Xu Z., Free PMC Article | 05/16/2020 |
| Pum1 and Pum2 regulate mouse body and organ size by post-transcriptional repression of the cell cycle inhibitor Cdkn1b. | Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.
Lin K, Qiang W, Zhu M, Ding Y, Shi Q, Chen X, Zsiros E, Wang K, Yang X, Kurita T, Xu EY., Free PMC Article | 04/18/2020 |
| This study used immunoassays, transmission electron microscopy and cardiac ultrasound to confirm that p27 haploinsufficiency prevents myocardial apoptosis by restoring autophagy protein 5mediated autophagy flux in the early stages of myocardial infarction. | p27kip1 haploinsufficiency preserves myocardial function in the early stages of myocardial infarction via Atg5‑mediated autophagy flux restoration.
Zhou N, Huang Q, Cheng W, Ge Y, Li D, Wang J., Free PMC Article | 02/22/2020 |
| Cytoplasmic p27(Kip1) promotes tumorigenesis by suppressing RhoB activity in non-small cell lung carcinoma cells. | Cytoplasmic p27(Kip1) promotes tumorigenesis via suppression of RhoB activity.
Calvayrac O, Nowosad A, Cabantous S, Lin LP, Figarol S, Jeannot P, Serres MP, Callot C, Perchey RT, Creff J, Taranchon-Clermont E, Rouquette I, Favre G, Pradines A, Manenti S, Mazieres J, Lee H, Besson A. | 12/21/2019 |
| p27(Kip1) stabilizes the alpha-tubulin acetyltransferase 1, thereby promoting the acetylation of microtubules, a post-translational modification required for proper axonal transport. | p27(Kip1) Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
Morelli G, Even A, Gladwyn-Ng I, Le Bail R, Shilian M, Godin JD, Peyre E, Hassan BA, Besson A, Rigo JM, Weil M, Brône B, Nguyen L. | 12/7/2019 |
| Study generated a knock-in mouse model in which T197 of p27 is replaced by an alanine (Cdkn1bT197A) to study the long-term effects of restoring p27 levels in vivo. Cdkn1bT197A/T197A mice present increased body size, organomegaly, and hyperplasia in multiple organs. This is an important model to study a variety of human proliferative disorders caused by increased turnover of p27 protein. | The T197A Knock-in Model of Cdkn1b Gene to Study the Effects of p27 Restoration In Vivo.
De Marco C, Rinaldo N, De Vita F, Forzati F, Caira E, Iovane V, Paciello O, Montanaro D, D'Andrea S, Baldassarre G, Papparella S, Malanga D, Baldi A, Viglietto G. | 11/30/2019 |
| HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors. | Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27(Kip1) levels and poor prognosis.
Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W., Free PMC Article | 10/26/2019 |
| the AMPK/p27(Kip1) pathway likely regulates the autophagy/apoptosis balance in aged MuSCs and may be a potential target for improving muscle regeneration in older individuals. | The AMPK/p27(Kip1) Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.
White JP, Billin AN, Campbell ME, Russell AJ, Huffman KM, Kraus WE., Free PMC Article | 10/5/2019 |