| CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. | CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma.
Yao Y, Ng JF, Park WD, Samur M, Morelli E, Encinas Mayoral J, Chyra Z, Xu Y, Derebail S, Epstein C, Nabet B, Chesi M, Gray NS, Young RA, Kwiatkowski N, Mitsiades C, Anderson KC, Lin CY, Munshi NC, Fulciniti M., Free PMC Article | 06/21/2023 |
| Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression. | Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression.
Dion V, Schumacher N, Masar N, Pieltain A, Tocquin P, Lesoinne P, Malgrange B, Vandenbosch R, Franzen R. | 07/16/2022 |
| Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway. | Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway.
Chen X, Li Y, Dai H, Zhang H, Wan D, Zhou X, Situ C, Zhu H. | 03/19/2022 |
| Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development. | Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.
Lee H, Ko HW., Free PMC Article | 05/1/2021 |
| the cyclin-dependent kinase CDK7 is regulated by miR-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development | CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Abdullah AI, Zhang H, Nie Y, Tang W, Sun T., Free PMC Article | 12/2/2017 |
| Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis. | Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Wang H, Jo YJ, Sun TY, Namgoong S, Cui XS, Oh JS, Kim NH. | 10/7/2017 |
| Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development. | Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M., Free PMC Article | 08/18/2012 |
| investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells | Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Patel SA, Simon MC., Free PMC Article | 06/28/2010 |
| Inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1. | SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.
Yang WH, Heaton JH, Brevig H, Mukherjee S, Iñiguez-Lluhí JA, Hammer GD., Free PMC Article | 01/21/2010 |
| results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity | Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
Helenius K, Yang Y, Alasaari J, Mäkelä TP., Free PMC Article | 01/21/2010 |
| Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity | The histidine triad protein Hint is not required for murine development or Cdk7 function.
Korsisaari N, Rossi DJ, Luukko K, Huebner K, Henkemeyer M, Mäkelä TP., Free PMC Article | 01/21/2010 |