| CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody. | CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody.
Akatsu C, Tsuneshige T, Numoto N, Long W, Uchiumi T, Kaneko Y, Asano M, Ito N, Tsubata T. | 06/14/2024 |
| CD22 and CD72 contribute to the development of scleroderma in a murine model. | CD22 and CD72 contribute to the development of scleroderma in a murine model.
Zhao C, Matsushita T, Ha Nguyen VT, Tennichi M, Fujimoto M, Takehara K, Hamaguchi Y. | 12/12/2020 |
| Reverse Arthus reaction model in the skin was induced in mice lacking CD22 (CD22-/-), CD72 (CD72-/-), and both of them (CD22-/-/CD72-/-) by immune complex challenge. Results demonstrate that CD22 and CD72 expression contribute to the development of the reverse Arthus reaction model and CD22 and CD72 might be therapeutic targets for human IC-mediated diseases. | CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model.
Nguyen VTH, Matsushita T, Zhao C, Fujimoto M, Takehara K, Tedder TF, Hamaguchi Y. | 04/4/2020 |
| CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP. | CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
Akatsu C, Shinagawa K, Numoto N, Liu Z, Ucar AK, Aslam M, Phoon S, Adachi T, Furukawa K, Ito N, Tsubata T., Free PMC Article | 08/12/2017 |
| CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha. | CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.
Kataoka TR, Kumanogoh A, Fukuishi N, Ueshima C, Hirata M, Moriyoshi K, Tsuruyama T, Haga H. | 09/26/2015 |
| CD5 and CD72 play a critical role in maintaining regulatory T and B cell homeostasis | Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis.
Zheng M, Xing C, Xiao H, Ma N, Wang X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R. | 05/16/2015 |
| These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation. | Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.
Xu M, Hou R, Sato-Hayashizaki A, Man R, Zhu C, Wakabayashi C, Hirose S, Adachi T, Tsubata T. | 07/27/2013 |
| Cd72 polymorphism affects susceptibility to lupus phenotypes. | A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice.
Oishi H, Tsubaki T, Miyazaki T, Ono M, Nose M, Takahashi S., Free PMC Article | 04/6/2013 |
| CD72 is an inhibitory receptor on NK cells regulating cytokine production. | B-cell co-receptor CD72 is expressed on NK cells and inhibits IFN-gamma production but not cytotoxicity.
Alcón VL, Luther C, Balce D, Takei F. | 01/21/2010 |
| CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance | Modulation of peripheral B cell tolerance by CD72 in a murine model.
Li DH, Winslow MM, Cao TM, Chen AH, Davis CR, Mellins ED, Utz PJ, Crabtree GR, Parnes JR., Free PMC Article | 01/21/2010 |
| Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response. | Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
Kumanogoh A, Shikina T, Watanabe C, Takegahara N, Suzuki K, Yamamoto M, Takamatsu H, Prasad DV, Mizui M, Toyofuku T, Tamura M, Watanabe D, Parnes JR, Kikutani H. | 01/21/2010 |
| CD72 plays a dominant role as a negative regulator of BCR signaling in primary mature B lymphocytes. | CD72 down-modulates BCR-induced signal transduction and diminishes survival in primary mature B lymphocytes.
Li DH, Tung JW, Tarner IH, Snow AL, Yukinari T, Ngernmaneepothong R, Martinez OM, Parnes JR. | 01/21/2010 |
| results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB, c-Myc, p27(Kip1) and cyclin | CD72 stimulation modulates anti-IgM induced apoptotic signaling through the pathway of NF-kappaB, c-Myc and p27(Kip1).
Fujiwara N, Fusaki N, Hozumi N. | 01/21/2010 |
| Inhibitory coreceptors CD72 and CD22 are responsible for setting the requirement of CD40 signaling for survival and proliferation of antigen-stimulated spleen B cells. | Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells.
Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T. | 01/21/2010 |
| CD72 activates extracellular signal-regulated kinase and c-Jun N-terminal kinase (but not p38 mitogen-activated protein kinase), synergizing with B cell receptor signals to induce proliferation of B cells in X-linked immunodeficiency. | Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.
Wu HJ, Venkataraman C, Estus S, Dong C, Davis RJ, Flavell RA, Bondada S. | 10/11/2001 |