| CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity. | CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity.
Nakai S, Kume M, Matsumura Y, Koguchi-Yoshioka H, Matsuda S, Fujimoto M, Watanabe R. | 05/31/2024 |
| CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. | CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
Blanco-Domínguez R, de la Fuente H, Rodríguez C, Martín-Aguado L, Sánchez-Díaz R, Jiménez-Alejandre R, Rodríguez-Arabaolaza I, Curtabbi A, García-Guimaraes MM, Vera A, Rivero F, Cuesta J, Jiménez-Borreguero LJ, Cecconi A, Duran-Cambra A, Taurón M, Alonso J, Bueno H, Villalba-Orero M, Enríquez JA, Robson SC, Alfonso F, Sánchez-Madrid F, Martínez-González J, Martín P., Free PMC Article | 11/5/2022 |
| The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment. | The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Nyambuya TM, Dludla PV, Nkambule BB. | 09/11/2021 |
| CD69 deficiency promotes a prothrombotic phenotype characterized by increased von Willebrand factor and worse brain damage after ischemic stroke. The results suggest that CD69 acts as a downregulator of endothelial activation. | CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation.
Brait VH, Miró-Mur F, Pérez-de-Puig I, Notario L, Hurtado B, Pedragosa J, Gallizioli M, Jiménez-Altayó F, Arbaizar-Rovirosa M, Otxoa-de-Amezaga A, Monteagudo J, Ferrer-Ferrer M, de la Rosa X, Bonfill-Teixidor E, Salas-Perdomo A, Hernández-Vidal A, Garcia-de-Frutos P, Lauzurica P, Planas AM. | 11/23/2019 |
| CD69 is important to the suppressive function of Tregs by promoting IL-10 production. | CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
Yu L, Yang F, Zhang F, Guo D, Li L, Wang X, Liang T, Wang J, Cai Z, Jin H., Free PMC Article | 11/16/2019 |
| Oxidized low-density lipoprotein binding to CD69 confers a regulatory phenotype to mouse T cells, dampening Th17 responses and ameliorating atherosclerosis. | Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease.
Tsilingiri K, de la Fuente H, Relaño M, Sánchez-Díaz R, Rodríguez C, Crespo J, Sánchez-Cabo F, Dopazo A, Alonso-Lebrero JL, Vara A, Vázquez J, Casasnovas JM, Alfonso F, Ibáñez B, Fuster V, Martínez-González J, Martín P, Sánchez-Madrid F. | 10/26/2019 |
| This study reveals the importance of CD69 to prolong the thymic residency time of developing immature precursors for proper differentiation of a T cell subset, NKT2 cells. | CD69 prevents PLZF(hi) innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation.
Kimura MY, Igi A, Hayashizaki K, Mita Y, Shinzawa M, Kadakia T, Endo Y, Ogawa S, Yagi R, Motohashi S, Singer A, Nakayama T., Free PMC Article | 01/19/2019 |
| These studies showed that VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS. | VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
Miyamoto Y, Torii T, Tanoue A, Yamauchi J., Free PMC Article | 08/25/2018 |
| AIM plays an orchestrating role in the resolution process of inflammation by altering the profile of pulmonary lipid mediators | Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, Miyazaki T, Nishimura M. | 12/2/2017 |
| Data show that a subset of inflammation-induced CD69(+) Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-beta1 at the late stage of immune response against infection. | Inflammation-induced CD69(+) Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1.
Zhang X, Jiang Z, Gu Y, Liu Y, Cao X, Han Y. | 07/22/2017 |
| Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance. | Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Takamura S, Yagi H, Hakata Y, Motozono C, McMaster SR, Masumoto T, Fujisawa M, Chikaishi T, Komeda J, Itoh J, Umemura M, Kyusai A, Tomura M, Nakayama T, Woodland DL, Kohlmeier JE, Miyazawa M., Free PMC Article | 07/22/2017 |
| this study shows that CD69 serves as a key mediator of the pathogenesis of psoriasis by controlling LAT1-CD98-mediated metabolic cues | CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.
Cibrian D, Saiz ML, de la Fuente H, Sánchez-Díaz R, Moreno-Gonzalo O, Jorge I, Ferrarini A, Vázquez J, Punzón C, Fresno M, Vicente-Manzanares M, Daudén E, Fernández-Salguero PM, Martín P, Sánchez-Madrid F., Free PMC Article | 06/3/2017 |
| Loss of CD69 is associated with enhanced protection against vaccinia virus infection. | CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis.
Notario L, Alari-Pahissa E, de Molina A, Lauzurica P., Free PMC Article | 05/20/2017 |
| The data highlight the contribution of CD69 as a nonredundant key regulator of BIC/miR-155-dependent regulatory T cell development and homeostasis. | Thymus-Derived Regulatory T Cell Development Is Regulated by C-Type Lectin-Mediated BIC/MicroRNA 155 Expression.
Sánchez-Díaz R, Blanco-Dominguez R, Lasarte S, Tsilingiri K, Martín-Gayo E, Linillos-Pradillo B, de la Fuente H, Sánchez-Madrid F, Nakagawa R, Toribio ML, Martín P., Free PMC Article | 05/13/2017 |
| Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2) gene was down-regulated, the expression of the CD69 antigen was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma were enhanced. | [Down-regulation of TIPE2 promotes the proliferation and immune activity of T lymphocytes].
Huang L, Chen J, Hong B. | 01/14/2017 |
| The generation of cancer-specific CD8(+) CD69(+)-expressing lymphocytes that inhibit colon cancer growth has been described. | Generation of cancer-specific CD8(+) CD69(+) cells inhibits colon cancer growth.
Lan B, Zhang J, Lu D, Li W. | 08/20/2016 |
| Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression. | Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression.
Cortés JR, Sánchez-Díaz R, Bovolenta ER, Barreiro O, Lasarte S, Matesanz-Marín A, Toribio ML, Sánchez-Madrid F, Martín P., Free PMC Article | 07/25/2015 |
| AIM(-/-) mice were highly susceptible to steatosis-associated HCC development, whereas no AIM(+/+) mouse developed the disease despite comparable liver inflammation and fibrosis in response to a long-term high-fat diet. | Circulating AIM prevents hepatocellular carcinoma through complement activation.
Maehara N, Arai S, Mori M, Iwamura Y, Kurokawa J, Kai T, Kusunoki S, Taniguchi K, Ikeda K, Ohara O, Yamamura KI, Miyazaki T. | 07/25/2015 |
| our findings reveal potent strategies to safely increase AIM levels, which could form the basis for developing novel therapies for obesity | Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.
Kai T, Yamazaki T, Arai S, Miyazaki T., Free PMC Article | 06/20/2015 |
| CD69 interference with S1P1 function regulates peripheral T cell retention. | Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.
Mackay LK, Braun A, Macleod BL, Collins N, Tebartz C, Bedoui S, Carbone FR, Gebhardt T. | 04/25/2015 |
| The NKG2A expression was increased in hepatic CD69-NK cells. | CD69+NK cells contribute to the murine hepatitis virus strain 3-induced murine hepatitis.
Ding L, Chen T, Wang XJ, Zhou L, Shi AC, Ning Q. | 09/13/2014 |
| Report role of ZAP-70 kinase mutation/deletion on thymocyte-positive selection via CD69 signaling. | A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.
Siggs OM, Yates AL, Schlenner S, Liston A, Lesage S, Goodnow CC., Free PMC Article | 05/3/2014 |
| The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. | The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.
Radulovic K, Rossini V, Manta C, Holzmann K, Kestler HA, Niess JH., Free PMC Article | 01/25/2014 |
| Data indicate that CD69 is upregulated on endogenous dendritic cells (DC) upon activation. | CD69 does not affect the extent of T cell priming.
Alari-Pahissa E, Notario L, Lorente E, Vega-Ramos J, Justel A, López D, Villadangos JA, Lauzurica P., Free PMC Article | 05/11/2013 |
| Intron I acts as an important regulatory element of CD69 expression. | Evidence for an intronic cis-regulatory element within CD69 gene.
Vazquez BN, Laguna T, Notario L, Lauzurica P. | 09/22/2012 |