| Alternatively Spliced Variants of Murine CD247 Influence T Cell Development and Activation, Revealing the Importance of the CD3zeta C-Terminal Region. | Alternatively Spliced Variants of Murine CD247 Influence T Cell Development and Activation, Revealing the Importance of the CD3ζ C-Terminal Region.
Jin Y, Yuan H, Mehta I, Ezenwa O, Morel PA., | 02/13/2024 |
| CD3zeta ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. | CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides.
Gaud G, Achar S, Bourassa FXP, Davies J, Hatzihristidis T, Choi S, Kondo T, Gossa S, Lee J, Juneau P, Taylor N, Hinrichs CS, McGavern DB, François P, Altan-Bonnet G, Love PE. | 12/5/2023 |
| The CD3zeta adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling. | The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL., Free PMC Article | 05/7/2022 |
| Study findings underline the important roles of p38 and STAT3 in the regulation of PD-L1 expression and prove that IFNalpha induces STAT3/p38-mediated expression of PD-L1 and thereby a reduced stimulatory ability of dendritic cells. | Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling.
Bazhin AV, von Ahn K, Fritz J, Werner J, Karakhanova S., Free PMC Article | 10/26/2019 |
| ITAM sequence diversity is required for optimal TCR signal transduction and subsequent T cell maturation | Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.
Bettini ML, Chou PC, Guy CS, Lee T, Vignali KM, Vignali DAA., Free PMC Article | 09/30/2017 |
| Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice | Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice.
Fornari TA, Donate PB, Assis AF, Macedo C, Sakamoto-Hojo ET, Donadi EA, Passos GA., Free PMC Article | 07/2/2016 |
| There is an early (within seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8 to MHC. | Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR., Free PMC Article | 10/17/2015 |
| The resting TCR localized in the disordered domain of giant plasma membrane (PM) vesicles (GPMVs) and PM spheres (PMSs) and single and nanoclustered TCRs are found in the high-density fractions in sucrose gradients. | Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains.
Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW. | 08/29/2015 |
| When Ly108 is engaged in trans during cell-cell interactions, Ly108-CD3zeta interactions are promoted in a manner that uniquely depends on Ly108 TM domain, leading to more efficient CD3zeta dephosphorylation. | SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.
Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, Dong Z, Yuan P, Wei W, Ma Y, Zhang L, Wu L, Qi H. | 01/10/2015 |
| Two transcription factor binding sites and a long non-coding RNA are identified within the Cd247 gene. | Spatially conserved regulatory elements identified within human and mouse Cd247 gene using high-throughput sequencing data from the ENCODE project.
Pundhir S, Hannibal TD, Bang-Berthelsen CH, Wegener AM, Pociot F, Holmberg D, Gorodkin J. | 08/30/2014 |
| Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection. | Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.
Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S., Free PMC Article | 08/9/2014 |
| The results of this study supported the model that the procognitive function of CD3zeta may be mediated through its involvement in the NMDAR downstream signaling pathway leading to CaMKII-dependent LTP induction. | Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency.
Louveau A, Angibaud J, Haspot F, Opazo MC, Thinard R, Thepenier V, Baudouin SJ, Lescaudron L, Hulin P, Riedel CA, Boudin H., Free PMC Article | 01/25/2014 |
| T cell CD3zeta deficiency enables multiorgan tissue inflammation. | T cell CD3ζ deficiency enables multiorgan tissue inflammation.
Deng GM, Beltran J, Chen C, Terhorst C, Tsokos GC., Free PMC Article | 11/30/2013 |
| Tyrosine phosphorylation of the TCR-zeta cytoplasmic domain regulates its association with the plasma membrane | Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
Zhang H, Cordoba SP, Dushek O, van der Merwe PA., Free PMC Article | 01/28/2012 |
| The data of this study suggested that CD3zeta mediates the ZAP-70/Syk kinase activation triggered by ephrinA-activated pathway to regulate early neuronal morphogenesis. | The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis.
Angibaud J, Louveau A, Baudouin SJ, Nerrière-Daguin V, Evain S, Bonnamain V, Hulin P, Csaba Z, Dournaud P, Thinard R, Naveilhan P, Noraz N, Pellier-Monnin V, Boudin H. | 12/24/2011 |
| Data show that TCRzeta phosphorylation signal pathways were affected in CD3gamma(-/-) primary and HVS-transformed T cells. | CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.
Reiné J, Busto EM, Muñoz-Ruiz M, Rossi NE, Rodríguez-Fernández JL, Martínez-Naves E, Regueiro JR, Recio MJ. | 12/10/2011 |
| functional role for CD3 zeta basic-rich stretch -phosphoinositide interactions in supporting T cell activation | The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.
DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS., Free PMC Article | 10/8/2011 |
| Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse. | RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA., Free PMC Article | 04/30/2011 |
| an intracellular pool of phosphorylated CD3zeta may help to sustain TcR/CD3 signaling after the receptor internalization. | Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.
Yudushkin IA, Vale RD., Free PMC Article | 02/5/2011 |
| The allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6, BALB/c, and C3H/HeJ mice. | Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.
Lundholm M, Mayans S, Motta V, Löfgren-Burström A, Danska J, Holmberg D. | 07/26/2010 |
| GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function | The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C., Free PMC Article | 06/28/2010 |
| a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs is required for effective iNKT cell development. | Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.
Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS., Free PMC Article | 06/28/2010 |
| We show that CD3zeta is expressed in retinal ganglion cells (RGCs). CD3zeta-deficient mice have reduced RGC dendritic motility, an increase in RGC dendritic density, and a selective defect of glutamate-receptor-mediated synaptic activity in the retina. | The immune protein CD3zeta is required for normal development of neural circuits in the retina.
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N., Free PMC Article | 03/29/2010 |
| Data show that In quiescent T cells, both TCR and Lat existed in separate membrane domains (protein islands), and these domains concatenated after T cell activation. | TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Lillemeier BF, Mörtelmaier MA, Forstner MB, Huppa JB, Groves JT, Davis MM., Free PMC Article | 01/21/2010 |
| 9-bp deletion in the 3'-UT region of the CD3zeta gene is associated with cutaneous angiosarcoma and gastric metastases. | New CD3zeta allele showing a 9-bp deletion in the 3'-UT region of the gene.
Aguinaga-Barrilero A, Rodríguez-Pérez N, Pérez-Blas M, Gutiérrez-Calvo A, Martín-Villa JM. | 01/21/2010 |