| Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes. | miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
Tao Y, Zhang H, Huang S, Pei L, Feng M, Zhao X, Ouyang Z, Yao S, Jiang R, Wei K. | 07/18/2020 |
| our study suggests that CD151 is a key player in the Wnt oncogene-driven tumorigenesis and impacts breast cancer malignancy in a cell type-dependent manner. | Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling.
Li H, Li J, Han R, Deng X, Shi J, Huang H, Hamad N, McCaughley A, Liu J, Wang C, Chen K, Wei D, Qiang J, Thatcher S, Wu Y, Liu C, Thibault O, Wei X, Chen S, Qian H, Zhou BP, Xu P, Yang XH., Free PMC Article | 04/25/2020 |
| CD151 is a critical novel host factor of nuclear export signaling. | CD151, a novel host factor of nuclear export signaling in influenza virus infection.
Qiao Y, Yan Y, Tan KS, Tan SSL, Seet JE, Arumugam TV, Chow VTK, Wang Y, Tran T. | 08/3/2019 |
| in complex with P2Y12 receptor contributes to thrombus growth and stability | A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
Makkawi M, Moheimani F, Alserihi R, Howells D, Wright M, Ashman L, Jackson DE. | 09/3/2016 |
| Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation | Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
Abdala-Valencia H, Bryce PJ, Schleimer RP, Wechsler JB, Loffredo LF, Cook-Mills JM, Hsu CL, Berdnikovs S., Free PMC Article | 11/28/2015 |
| Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program. | CD151 represses mammary gland development by maintaining the niches of progenitor cells.
Yin Y, Deng X, Liu Z, Baldwin LA, Lefringhouse J, Zhang J, Hoff JT, Erfani SF, Rucker EB 3rd, O'Connor K, Liu C, Wu Y, Zhou BP, Yang XH., Free PMC Article | 07/25/2015 |
| Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes. | Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.
Roselli S, Kahl RG, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK., Free PMC Article | 02/28/2015 |
| We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis. | Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.
Sachs N, Secades P, van Hulst L, Song JY, Sonnenberg A., Free PMC Article | 03/8/2014 |
| Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma. | Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.
Li Q, Yang XH, Xu F, Sharma C, Wang HX, Knoblich K, Rabinovitz I, Granter SR, Hemler ME., Free PMC Article | 05/25/2013 |
| study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (and EGFR) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis | Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi Y, Zhou P, Stipp CS, Kaetzel DM, Hemler ME, Yang XH., Free PMC Article | 03/2/2013 |
| CD151 importantly modulates podocyte function. | Morphology and migration of podocytes are affected by CD151 levels.
Blumenthal A, Giebel J, Ummanni R, Schlüter R, Endlich K, Endlich N. | 07/21/2012 |
| establish CD151 as a crucial modifier of integrin-mediated adhesion of podocytes to the GBM and show that blood pressure is an important factor in the initiation and progression of Cd151 knockout-induced nephropathy | Blood pressure influences end-stage renal disease of Cd151 knockout mice.
Sachs N, Claessen N, Aten J, Kreft M, Teske GJ, Koeman A, Zuurbier CJ, Janssen H, Sonnenberg A., Free PMC Article | 03/10/2012 |
| CD151 maintains vascular stability by promoting endothelial cell adhesions, especially cell-cell adhesion, and confining cytoskeletal tension. | Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension.
Zhang F, Michaelson JE, Moshiach S, Sachs N, Zhao W, Sun Y, Sonnenberg A, Lahti JM, Huang H, Zhang XA., Free PMC Article | 12/3/2011 |
| diminished metastasis in CD151-null host animals may be due to impaired tumor-endothelial interactions, with underlying defects in mouse lung endothelial cell extracellular matrix production. | Diminished metastasis in tetraspanin CD151-knockout mice.
Takeda Y, Li Q, Kazarov AR, Epardaud M, Elpek K, Turley SJ, Hemler ME., Free PMC Article | 10/1/2011 |
| CD151 controls Met-dependent neoplastic growth by enhancing receptor signaling through beta4 integrin-mediated pathways, independent of cell-substrate adhesion | The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.
Franco M, Muratori C, Corso S, Tenaglia E, Bertotti A, Capparuccia L, Trusolino L, Comoglio PM, Tamagnone L., Free PMC Article | 01/15/2011 |
| CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation | Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC.
Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, Wright MD. | 01/21/2010 |
| CD151 is a key regulator of MT1-MMP in endothelial homeostasis | MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells.
Yañez-Mó M, Barreiro O, Gonzalo P, Batista A, Megías D, Genís L, Sachs N, Sala-Valdés M, Alonso MA, Montoya MC, Sonnenberg A, Arroyo AG, Sánchez-Madrid F. | 01/21/2010 |
| CD151 appears to be involved in the establishment, maturation, and/or maintenance of the glomerular basement membrane structure in addition to its role in integrin-mediated adhesion strengthening. | Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane.
Baleato RM, Guthrie PL, Gubler MC, Ashman LK, Roselli S., Free PMC Article | 01/21/2010 |
| Data implicate CD151 as a facilitator of laminin-332-mediated keratinocyte functions that impact on the re-epithelialisation process intrinsic to wound healing and further suggest a potential novel role for CD151 in fibroblast migration. | The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing.
Geary SM, Cowin AJ, Copeland B, Baleato RM, Miyazaki K, Ashman LK. | 01/21/2010 |
| Demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site. | The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP., Free PMC Article | 01/21/2010 |
| CD151 may be involved in the interaction of platelets with the subendothelial matrix at sites of vascular damage [review] | CD151.
Ashman LK. | 01/21/2010 |
| CD151-null mice show phenotypes in several different tissue types: a minor abnormality in hemostasis; keratinocytes migrate poorly in skin explant cultures; T lymphocytes are hyperproliferative in response to in vitro mitogenic stimulation. | Characterization of mice lacking the tetraspanin superfamily member CD151.
Wright MD, Geary SM, Fitter S, Moseley GW, Lau LM, Sheng KC, Apostolopoulos V, Stanley EG, Jackson DE, Ashman LK., Free PMC Article | 01/21/2010 |
| CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect | The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function.
Lau LM, Wee JL, Wright MD, Moseley GW, Hogarth PM, Ashman LK, Jackson DE. | 01/21/2010 |
| CD151 modulates molecular organization of laminin-binding integrins, thereby supporting secondary (ie, after cell adhesion) functions of endothelial cells, which are needed for some types of pathologic angiogenesis | Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.
Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME., Free PMC Article | 01/21/2010 |
| CD151 plays a key role in selectively strengthening alpha6beta1 integrin-mediated adhesion to laminin-1 | Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening.
Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME., Free PMC Article | 01/21/2010 |