| SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction. | SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction.
Zhang Y, Liu G, Huang L, He X, Su Y, Nie X, Mao Z, Xing X. | 07/16/2024 |
| SEPTIN12 c.474 G > A polymorphism as a risk factor in teratozoospermic patients. | SEPTIN12 c.474 G > A polymorphism as a risk factor in teratozoospermic patients.
Özkara G, Ersoy Tunali N. | 12/11/2021 |
| Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility. | Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility.
Rafaee A, Mohseni Meybodi A, Yaghmaei P, Hosseini SH, Sabbaghian M. | 01/16/2021 |
| Single nucleotide polymorphism c.673C>A/p.Gln225Lys in SEPT12 gene is associated with male idiopathic infertility. | Association of single nucleotide polymorphism c.673C>A/p.Gln225Lys in SEPT12 gene with spermatogenesis failure in male idiopathic infertility in Northeast China.
Geng D, Yang X, Zhang H, Liu X, Yu Y, Jiang Y, Liu R, Zhang G., Free PMC Article | 06/15/2019 |
| the current work identified the promoter of the human SEPT12 gene and provided key evidence about its transcriptional regulation via E2 and 5alpha-DHT. | Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.
Kuo PL, Tseng JY, Chen HI, Wu CY, Omar HA, Wang CY, Cheng HY, Hsu CC, Fu TF, Teng YN. | 03/2/2019 |
| In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail. | SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.
Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS, Kuo PL, Lin YH., Free PMC Article | 04/22/2017 |
| results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility. | SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins.
Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY, Kuo PL. | 12/26/2015 |
| we discovered that the SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis | SEPT12-microtubule complexes are required for sperm head and tail formation.
Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH., Free PMC Article | 06/7/2014 |
| SEPTIN12 genetic variants confer susceptibility to teratozoospermia | SEPTIN12 genetic variants confer susceptibility to teratozoospermia.
Lin YH, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL., Free PMC Article | 11/17/2012 |
| Eight coding single-nucleotide polymorphisms in SEPTIN12 were detected in the patients with Sertoli cell-only syndrome. Analysis of the results suggest that SEPTIN12 might play a critical role in human spermatogenesis. | Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.
Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K. | 10/6/2012 |
| SEPT12 mutations cause male infertility with defective sperm annulus and disrupt sperm structural integrity | SEPT12 mutations cause male infertility with defective sperm annulus.
Kuo YC, Lin YH, Chen HI, Wang YY, Chiou YW, Lin HH, Pan HA, Wu CM, Su SM, Hsu CC, Kuo PL. | 07/14/2012 |
| The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest | Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men.
Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K., Free PMC Article | 06/23/2012 |
| Decreases in SEPTIN12 expression is associated with male infertility. | The expression level of septin12 is critical for spermiogenesis.
Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL., Free PMC Article | 01/21/2010 |
| While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively. | SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells.
Ding X, Yu W, Liu M, Shen S, Chen F, Wan B, Yu L. | 01/21/2010 |