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    ABCC2 ATP binding cassette subfamily C member 2 [ Homo sapiens (human) ]

    Gene ID: 1244, updated on 5-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association Between ABCC2 -24C>T and Nab-Paclitaxel-induced Peripheral Neuropathy in Japanese Patients With Pancreatic Cancer.

    Association Between ABCC2 -24C>T and Nab-Paclitaxel-induced Peripheral Neuropathy in Japanese Patients With Pancreatic Cancer.
    Nakayama H, Ishida H, Iidaka M, Kato S, Nakatani K, Nakayama A, Noguchi T, Nishihara S, Oikawa S, Usami T, Mitsui Y, Ishii YU, Toshima H, Kobayashi K, Murase R, Matsumoto N, Suzuki K, Shimada K, Yoshida H, Fujita KI.

    11/5/2024
    In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants.

    In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants.
    Kölz C, Gaugaz FZ, Handin N, Schaeffeler E, Tremmel R, Winter S, Klein K, Zanger UM, Artursson P, Schwab M, Nies AT.

    10/8/2024
    ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer.

    ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer.
    Wang Y, Gan X, Cheng X, Jia Y, Wang G, Tang X, Du H, Li X, Liu X, Xing X, Ji J, Li Z., Free PMC Article

    09/12/2024
    Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.

    Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.
    Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y., Free PMC Article

    03/8/2024
    Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.

    Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.
    Sharma P, Singh N, Sharma S.

    04/12/2023
    Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single-Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real-Life Study.

    Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single-Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real-Life Study.
    Barnett-Griness O, Rennert G, Lejbkowicz F, Pinchev M, Saliba W, Gronich N.

    03/13/2023
    Impact of ABCC2 1249G>A and -24C>T Polymorphisms on Lacosamide Efficacy and Plasma Concentrations in Uygur Pediatric Patients With Epilepsy in China.

    Impact of ABCC2 1249G>A and -24C>T Polymorphisms on Lacosamide Efficacy and Plasma Concentrations in Uygur Pediatric Patients With Epilepsy in China.
    Zhao T, Li HJ, Zhang HL, Feng J, Yu J, Wang TT, Sun Y, Yu LH., Free PMC Article

    01/21/2023
    Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.

    Concurrence of novel mutations causing Gilbert's and Dubin-Johnson syndrome with poor clinical outcomes in a Han Chinese family.
    Zhou TC, Li X, Li H, Liu FW, Zhang SH, Fan JH, Yang WX, Yang YL, Zhang L, Wei J., Free PMC Article

    01/14/2023
    Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.

    Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.
    Li M, Kong XY, Wang SM.

    01/14/2023
    In silico screening and analysis of single-nucleotide polymorphic variants of the ABCC2 gene affecting Dubin-Johnson syndrome.

    In silico screening and analysis of single-nucleotide polymorphic variants of the ABCC2 gene affecting Dubin-Johnson syndrome.
    Sharma P, Sharma S.

    10/1/2022
    Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine.

    Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine.
    Kikuchi T, Hayashi A, Ikeda N, Morita O, Tasaki J.

    08/6/2022
    Contribution of child ABC-transporter genetics to prenatal MeHg exposure and neurodevelopment.

    Contribution of child ABC-transporter genetics to prenatal MeHg exposure and neurodevelopment.
    Love TM, Wahlberg K, Pineda D, Watson GE, Zareba G, Thurston SW, Davidson PW, Shamlaye CF, Myers GJ, Rand M, van Wijngaarden E, Broberg K., Free PMC Article

    07/30/2022
    The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.

    The ABCB1, ABCC2 and RALBP1 polymorphisms are associated with carbamazepine response in epileptic patient: a systematic review.
    Boughrara W, Chentouf A.

    07/30/2022
    Slug Mediates MRP2 Expression in Non-Small Cell Lung Cancer Cells.

    Slug Mediates MRP2 Expression in Non-Small Cell Lung Cancer Cells.
    Zhang X, Liu W, Edaki K, Nakazawa Y, Takahashi S, Sunakawa H, Mizoi K, Ogihara T., Free PMC Article

    07/2/2022
    ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade.

    ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade.
    Saleeb RM, Brimo F, Gao Y, Boulos C, Kim SS, Al Bashir S, Husain A, Rotondo F, Beharry V, Bjarnason GA, Krizova A, Trpkov K, Yousef GM.

    05/21/2022
    A systematic review and meta-analysis of the association of ABCC2/ABCG2 polymorphisms with antiepileptic drug responses in epileptic patients.

    A systematic review and meta-analysis of the association of ABCC2/ABCG2 polymorphisms with antiepileptic drug responses in epileptic patients.
    Zan X, Yue G, Hao Y, Sima X.

    04/2/2022
    Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients.

    Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients.
    Brazeau D, Meaney CJ, Consiglio JD, Wilding GE, Cooper LM, Venuto RC, Tornatore KM., Free PMC Article

    02/19/2022
    Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.

    Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.
    Duran G, Cruz R, Aguín S, Barros F, Giráldez JM, Bernárdez B, Zarra I, López-López R, Carracedo Á, Lamas MJ.

    01/8/2022
    The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia.

    The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia.
    Huang YS, Chang TE, Perng CL, Huang YH.

    12/25/2021
    Polymorphism in Gene for ABCC2 Transporter Predicts Methotrexate Drug Survival in Patients with Psoriasis.

    Polymorphism in Gene for ABCC2 Transporter Predicts Methotrexate Drug Survival in Patients with Psoriasis.
    Grželj J, Marovt M, Marko PB, Mlinarič-Raščan I, Gmeiner T, Šmid A., Free PMC Article

    10/30/2021
    Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.

    Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
    Ontsouka E, Epstein A, Kallol S, Zaugg J, Baumann M, Schneider H, Albrecht C., Free PMC Article

    10/30/2021
    Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR.

    Cigarette smoke extract combined with LPS down-regulates the expression of MRP2 in chronic pulmonary inflammation may be related to FXR.
    Fang X, Zhang S, Wang Z, Zhou J, Qi C, Song J.

    10/2/2021
    A recurrent ABCC2 p.G693R mutation resulting in loss of function of MRP2 and hyperbilirubinemia in Dubin-Johnson syndrome in China.

    A recurrent ABCC2 p.G693R mutation resulting in loss of function of MRP2 and hyperbilirubinemia in Dubin-Johnson syndrome in China.
    Wu L, Li Y, Song Y, Zhou D, Jia S, Xu A, Zhang W, You H, Jia J, Huang J, Ou X., Free PMC Article

    07/31/2021
    Increased ABCC2 expression predicts cisplatin resistance in non-small cell lung cancer.

    Increased ABCC2 expression predicts cisplatin resistance in non-small cell lung cancer.
    Chen Y, Zhou H, Yang S, Su D., Free PMC Article

    07/10/2021
    Mutation spectrum and biochemical features in infants with neonatal Dubin-Johnson syndrome.

    Mutation spectrum and biochemical features in infants with neonatal Dubin-Johnson syndrome.
    Kim KY, Kim TH, Seong MW, Park SS, Moon JS, Ko JS., Free PMC Article

    06/19/2021
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