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    CMKLR1 chemerin chemokine-like receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1240, updated on 27-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.

    GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
    Wang D, Mahmud I, Thakur VS, Tan SK, Isom DG, Lombard DB, Gonzalgo ML, Kryvenko ON, Lorenzi PL, Tcheuyap VT, Brugarolas J, Welford SM.,

    08/14/2024
    Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.

    Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
    Daneshfar N, Falahi S, Gorgin Karaji A, Rezaiemanesh A, Mortazavi SHR, Akbari B, Eivazi A, Salari F.

    07/31/2024
    Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.

    Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
    Kretschmer K, Zellmann T, Mörl K, Beck-Sickinger AG.

    09/20/2023
    ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.

    ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
    Lavy M, Gauttier V, Dumont A, Chocteau F, Deshayes S, Fresquet J, Dehame V, Girault I, Trilleaud C, Neyton S, Mary C, Juin P, Poirier N, Barillé-Nion S, Blanquart C., Free PMC Article

    08/7/2023
    [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].

    [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
    Hu XY, Wang N, Zhang XY, Yang Q, Gao F, Xiang FG, Feng YY.

    05/12/2023
    Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.

    Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
    Zhang Z, Ding Y, Li J, Su S.

    03/13/2023
    Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.

    Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
    Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD., Free PMC Article

    03/9/2023
    Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.

    Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
    Estienne A, Mellouk N, Bongrani A, Plotton I, Langer I, Ramé C, Petit C, Guérif F, Froment P, Dupont J.

    03/19/2022
    Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.

    Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
    Yanofsky R, Sancho C, Gasbarrino K, Zheng H, Doonan RJ, Jaunet F, Steinmetz-Wood S, Veinot JP, Lai C, Daskalopoulou SS.

    01/8/2022
    The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.

    The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
    Kiczmer P, Mielcarska S, Chrabańska M, Dawidowicz M, Kula A, Rynkiewicz M, Seńkowska AP, Waniczek D, Piecuch J, Jopek J, Kajor M, Świętochowska E., Free PMC Article

    01/1/2022
    GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer.

    GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer.
    Mielcarska S, Stopińska K, Dawidowicz M, Kula A, Kiczmer P, Seńkowska AP, Zajdel EN, Walkiewicz K, Waniczek D, Świętochowska E.

    12/25/2021
    Serum resolvin E1 levels and its relationship with thyroid autoimmunity in Hashimoto's thyroiditis: a preliminary study.

    Serum resolvin E1 levels and its relationship with thyroid autoimmunity in Hashimoto's thyroiditis: a preliminary study.
    Song J, Sun R, Zhang Y, Ke J, Zhao D., Free PMC Article

    11/22/2021
    SPM Receptor Expression and Localization in Irradiated Salivary Glands.

    SPM Receptor Expression and Localization in Irradiated Salivary Glands.
    Dos Santos HT, Nam K, Hunt JP, Buchmann LO, Monroe MM, Baker OJ., Free PMC Article

    10/23/2021
    Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis.

    Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis.
    Artiach G, Carracedo M, Plunde O, Wheelock CE, Thul S, Sjövall P, Franco-Cereceda A, Laguna-Fernandez A, Arnardottir H, Bäck M., Free PMC Article

    09/4/2021
    CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis.

    CCR2/CCL2 and CMKLR1/RvE1 chemokines system levels are associated with insulin resistance in rheumatoid arthritis.
    Diaz-Rubio GI, Corona-Meraz FI, Madrigal-Ruiz PM, Robles-De Anda JA, Gómez-Bañuelos E, Castro-Albarran J, Flores-Alvarado LJ, Vázquez-Del Mercado M, Pérez-Vázquez FJ, Pizano-Martínez OE, Navarro-Hernández RE., Free PMC Article

    06/26/2021
    Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.

    Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.
    Hu S, Shao Z, Zhang C, Chen L, Mamun AA, Zhao N, Cai J, Lou Z, Wang X, Chen J., Free PMC Article

    03/13/2021
    Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.

    Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.
    Feder S, Bruckmann A, McMullen N, Sinal CJ, Buechler C., Free PMC Article

    02/27/2021
    Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity.

    Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity.
    Rowicka G, Dyląg H, Chełchowska M, Weker H, Ambroszkiewicz J., Free PMC Article

    01/2/2021
    CMKLR1 activity may be associated with the angiogenic process in colorectal cancer via MMP-9 activity.

    Assessment of CMKLR1 level in colorectal cancer and its correlation with angiogenic markers.
    Kiczmer P, Seńkowska AP, Kula A, Dawidowicz M, Strzelczyk JK, Zajdel EN, Walkiewicz K, Waniczek D, Ostrowska Z, Świętochowska E.

    07/25/2020
    chemerin/ChemR23 axis played an important role in endothelial injury and inflammation in diabetic nephropathy.

    Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.
    Shang J, Wang L, Zhang Y, Zhang S, Ning L, Zhao J, Cheng G, Liu D, Xiao J, Zhao Z., Free PMC Article

    07/18/2020
    The majority of presented data report down-regulation of chemerin in cancer tissue and suggest a tumor-suppressing role of chemerin in most cancer types, being mediated by recruiting innate immune defenses and by growth-inhibitory downstream signaling by chemerin receptors CMKLR1 and GPR1. (Review)

    Chemerin and Cancer.
    Treeck O, Buechler C, Ortmann O., Free PMC Article

    01/4/2020
    Chemerin/ChemR23 promotes tumorigenesis and metastasis in oral squamous cell carcinoma cells.

    The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma.
    Lu Z, Liang J, He Q, Wan Q, Hou J, Lian K, Wang A.

    12/7/2019
    Report a modest inverse association between chemerin and ankle-brachial index that remained consistent after adjustment for metabolic and inflammatory parameters in subclinical atherosclerosis.

    Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis: Results of a Population-Based Study.
    Zylla S, Dörr M, Völzke H, Schminke U, Felix SB, Nauck M, Friedrich N., Free PMC Article

    07/20/2019
    This study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.

    Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals.
    López-Vicario C, Rius B, Alcaraz-Quiles J, González-Périz A, Martínez-Puchol AI, Casulleras M, Duran-Güell M, Ibarzabal A, Corcelles R, Laguna-Fernández A, Back M, Titos E, Clària J., Free PMC Article

    07/6/2019
    Chemerin upregulated expression and phosphatase activity of PTEN by interfering with PTEN-CMKLR1 interaction, leading to weakened ubiquitination of PTEN and decreased p-Akt (Ser473) level, which was responsible for suppressed migration, invasion and metastasis of HCC cells.

    Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.
    Li JJ, Yin HK, Guan DX, Zhao JS, Feng YX, Deng YZ, Wang X, Li N, Wang XF, Cheng SQ, Bao Y, Xie D., Free PMC Article

    06/29/2019
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