| The chemokine receptor CCR8 is not a high-affinity receptor for the human chemokine CCL18. | The chemokine receptor CCR8 is not a high-affinity receptor for the human chemokine CCL18.
Hussain K, Lim HD, Devkota SR, Kemp-Harper BK, Lane JR, Canals M, Pease JE, Stone MJ., Free PMC Article | 09/19/2024 |
| Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8. | Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8.
Peng Q, Jiang H, Cheng X, Wang N, Zhou S, Zhang Y, Yang T, Chen Y, Zhang W, Lv S, Nan W, Wang J, Fan GH, Li J, Zhang J. | 09/13/2024 |
| Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F., Free PMC Article | 02/7/2024 |
| Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells. | Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells.
Liu L, Rangan L, Vanalken N, Kong Q, Schlenner S, De Jonghe S, Schols D, Van Loy T., Free PMC Article | 02/6/2024 |
| Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. | Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody.
Weaver JD, Stack EC, Buggé JA, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu CA, Krukenberg K, Zhang Y, Ezzyat Y, Saddier Axe D, Kuhne MR, Meehl MA, Shaffer DR, Weist BM, Wiederschain D, Depis F, Gostissa M., Free PMC Article | 11/19/2022 |
| Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells. | Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells.
Ding D, Zhang L, Liu X, Sun C, He J, Li J, Gao X, Guan F, Zhang L. | 03/19/2022 |
| CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. | CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S., Free PMC Article | 03/12/2022 |
| Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway. | Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway.
Fraga M, Yáñez M, Sherman M, Llerena F, Hernandez M, Nourdin G, Álvarez F, Urrizola J, Rivera C, Lamperti L, Nova L, Castro S, Zambrano O, Cifuentes A, Campos L, Moya S, Pastor J, Nuñez M, Gatica J, Figueroa J, Zúñiga F, Salomón C, Cerda G, Puentes R, Labarca G, Vidal M, McGregor R, Nova-Lamperti E., Free PMC Article | 09/25/2021 |
| Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors. | Clinical and prognostic significance of CC chemokine receptor type 8 protein expression in gastrointestinal stromal tumors.
Li HL, Wang LH, Hu YL, Feng Y, Li XH, Liu YF, Li P, Mao QS, Xue WJ., Free PMC Article | 07/10/2021 |
| Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. | Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.
Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H. | 04/17/2021 |
| ARNT-dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer. | ARNT-dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer.
Chen G, Cai ZD, Lin ZY, Wang C, Liang YX, Han ZD, He HC, Mo RJ, Lu JM, Pan B, Wu CL, Wang F, Zhong WD. | 10/10/2020 |
| Blocking CCR8 via a small molecule inhibitor or short hairpin (sh)RNA mitigated the decrease in Ecadherin, and increase in MMP2 and VEGFC, caused by human recombinant (r)CCL18. CCR8 knockdown by shRNA reversed rCCL18induced cancer cell invasion, migration and epithelialmesenchymal transition | CCL18 enhances migration, invasion and EMT by binding CCR8 in bladder cancer cells.
Liu X, Xu X, Deng W, Huang M, Wu Y, Zhou Z, Zhu K, Wang Y, Cheng X, Zhou X, Chen L, Li Y, Wang G, Fu B., Free PMC Article | 05/25/2019 |
| Long-lived memory T cells in human skin can be defined by the expression of CCR8. | CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin.
McCully ML, Ladell K, Andrews R, Jones RE, Miners KL, Roger L, Baird DM, Cameron MJ, Jessop ZM, Whitaker IS, Davies EL, Price DA, Moser B., Free PMC Article | 02/16/2019 |
| Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. | CCR8(+)FOXp3(+) T(reg) cells as master drivers of immune regulation.
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N., Free PMC Article | 05/26/2018 |
| Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. | Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
Barington L, Rummel PC, Lückmann M, Pihl H, Larsen O, Daugvilaite V, Johnsen AH, Frimurer TM, Karlshøj S, Rosenkilde MM., Free PMC Article | 05/13/2017 |
| High CCR8 expression is associated with high recurrence in kidney cancer. | Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients.
Fu Q, Chang Y, Zhou L, An H, Zhu Y, Xu L, Zhang W, Xu J., Free PMC Article | 12/24/2016 |
| findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease | Expression of the chemokine receptor gene, CCR8, is associated With DUSP22 rearrangements in anaplastic large cell lymphoma.
Xing X, Flotte TJ, Law ME, Blahnik AJ, Chng WJ, Huang G, Knudson RA, Ketterling RP, Porcher JC, Ansell SM, Sidhu J, Dogan A, Feldman AL., Free PMC Article | 06/11/2016 |
| Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. | Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
McCully ML, Collins PJ, Hughes TR, Thomas CP, Billen J, O'Donnell VB, Moser B., Free PMC Article | 09/5/2015 |
| CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. | Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis.
Zen Y, Liberal R, Nakanuma Y, Heaton N, Portmann B. | 10/4/2014 |
| Identification of human CCR8 as a CCL18 receptor. | Identification of human CCR8 as a CCL18 receptor.
Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD., Free PMC Article | 11/23/2013 |
| CCR8(+) myeloid cell subset is expanded in patients with cancer. | Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas.
Eruslanov E, Stoffs T, Kim WJ, Daurkin I, Gilbert SM, Su LM, Vieweg J, Daaka Y, Kusmartsev S., Free PMC Article | 09/28/2013 |
| Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. | Epidermis instructs skin homing receptor expression in human T cells.
McCully ML, Ladell K, Hakobyan S, Mansel RE, Price DA, Moser B., Free PMC Article | 02/9/2013 |
| C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity | C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.
Denis C, Deiteren K, Mortier A, Tounsi A, Fransen E, Proost P, Renauld JC, Lambeir AM., Free PMC Article | 11/17/2012 |
| The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. | CCR8 signaling influences Toll-like receptor 4 responses in human macrophages in inflammatory diseases.
Reimer MK, Brange C, Rosendahl A., Free PMC Article | 03/17/2012 |
| There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. | Expression of CCR8 is increased in asthma.
Mutalithas K, Guillen C, Raport C, Kolbeck R, Soler D, Brightling CE, Pavord ID, Wardlaw AJ., Free PMC Article | 11/13/2010 |