| SH2-B dramatically enhanced leptin-stimulated tyrosine phosphorylation of IRS1 and IRS2 in human and mouse cells. [SH2-B] | SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin.
Duan C, Li M, Rui L., Free PMC Article | 10/25/2019 |
| Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models. | Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T., Free PMC Article | 10/11/2014 |
| caspase-14 overexpression is not the cause of utricle formation | Caspase-14 overexpression in hairless mice is not involved in utricle formation.
Devos M, De Groote P, Gilbert B, Bruggeman I, Leurs K, Lippens S, Vandenabeele P, Declercq W. | 02/15/2014 |
| Caspase-14-deficient mice are more prone to the development of parakeratosis. | Caspase-14-deficient mice are more prone to the development of parakeratosis.
Hoste E, Denecker G, Gilbert B, Van Nieuwerburgh F, van der Fits L, Asselbergh B, De Rycke R, Hachem JP, Deforce D, Prens EP, Vandenabeele P, Declercq W. | 06/22/2013 |
| Mere impairment of filaggrin degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis. | Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis.
Devos M, Prawitt J, Staumont-Salle D, Hoste E, Fleury S, Bouchaert E, Gilbert B, Lippens S, Vandenabeele P, Dombrowicz D, Declercq W. | 02/2/2013 |
| Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. | Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, Gilbert B, Lippens S, De Groote P, Roelandt R, Van Damme P, Gevaert K, Presland RB, Takahara H, Puppels G, Caspers P, Vandenabeele P, Declercq W. | 01/21/2012 |
| Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis. | Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
Asselin-Labat ML, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S, Breslin K, Ward T, Shi W, Bath ML, Deb S, Fox SB, Smyth GK, Lindeman GJ, Visvader JE., Free PMC Article | 12/24/2011 |
| We investigated whether cardiac autonomic control is impaired during sleep in ob/ob mice with morbid obesity caused by congenital leptin deficiency. | Dysregulation of heart rhythm during sleep in leptin-deficient obese mice.
SilvanI A, Bastianini S, Berteotti C, Franzini C, Lenzi P, Lo Martire V, Zoccoli G., Free PMC Article | 04/19/2010 |
| permeability barrier requirements coordinately drive both the generation of the stratum corneum lipid-enriched extracellular matrix and the transformation of granular cells into corneocytes, in an SP- and Casp-14-dependent manner, signaled by PAR2 | Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2.
Demerjian M, Hachem JP, Tschachler E, Denecker G, Declercq W, Vandenabeele P, Mauro T, Hupe M, Crumrine D, Roelandt T, Houben E, Elias PM, Feingold KR., Free PMC Article | 01/21/2010 |
| Caspase-14, but not caspase-3 activation coincides temporally and spatially with embryonic KC differentiation, suggesting a role for caspase-14 in terminally differentiated KC. | Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis.
Fischer H, Rossiter H, Ghannadan M, Jaeger K, Barresi C, Declercq W, Tschachler E, Eckhart L. | 01/21/2010 |
| The skin of caspase-14-deficient mice was shiny and lichenified, indicating an altered stratum-corneum composition. It contained significantly more alveolar keratohyalin F-granules, the profilaggrin stores. | Caspase-14 protects against epidermal UVB photodamage and water loss.
Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, Van den Broecke C, Van Damme P, D'Herde K, Hachem JP, Borgonie G, Presland RB, Schoonjans L, Libert C, Vandekerckhove J, Gevaert K, Vandenabeele P, Declercq W. | 01/21/2010 |
| processing of caspase 14 in epidermal differentiation | Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.
Chien AJ, Presland RB, Kuechle MK. | 01/21/2010 |