| HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells. | HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells.
Chan JW, Neo CWY, Ghosh S, Choi H, Lim SC, Tai ES, Teo AKK., Free PMC Article | 05/9/2023 |
| Study found lower organic solute transporter beta (OSTbeta) expression in colon cancer tissues compared with adjacent normal tissues and revealed the epigenetic mechanisms of it and proved that p300 controls OSTbeta expression through modulating H3K27Ac state at OSTbeta promoter region and hence causes low expression of OSTbeta in colorectal cancer. | Epigenetic Mechanisms Underlying Organic Solute Transporter β Repression in Colorectal Cancer.
Zhou Y, Ye C, Lou Y, Liu J, Ye S, Chen L, Lei J, Guo S, Zeng S, Yu L. | 05/9/2020 |
| Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting. | A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.
Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL., Free PMC Article | 07/29/2017 |
| Hepatic OSTalpha-OSTbeta expression is induced by hypoxia. | The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.
Schaffner CA, Mwinyi J, Gai Z, Thasler WE, Eloranta JJ, Kullak-Ublick GA., Free PMC Article | 12/19/2015 |
| OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways | A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression.
Xu S, Sun AQ, Suchy FJ., Free PMC Article | 03/8/2014 |
| Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes. | β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.
Christian WV, Li N, Hinkle PM, Ballatori N., Free PMC Article | 08/25/2012 |
| The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues. | Pleiotropic functions of the organic solute transporter Ostα-Ostβ.
Ballatori N., Free PMC Article | 10/29/2011 |
| OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis | Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N., Free PMC Article | 10/23/2010 |
| interaction of solute transporter beta with human organic solute transporter alpha. | N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.
Soroka CJ, Xu S, Mennone A, Lam P, Boyer JL., Free PMC Article | 01/21/2010 |
| The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers | Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.
Renner O, Harsch S, Strohmeyer A, Schimmel S, Stange EF. | 01/21/2010 |
| Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity. | Protein-protein interactions and membrane localization of the human organic solute transporter.
Sun AQ, Balasubramaniyan N, Xu K, Liu CJ, Ponamgi VM, Liu H, Suchy FJ. | 01/21/2010 |
| These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. | Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. | 01/21/2010 |
| OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR). | The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA. | 01/21/2010 |
| the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. | OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N. | 01/21/2010 |
| OSTbeta has roles in biological transport and is widely expressed in human tissues | Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.
Seward DJ, Koh AS, Boyer JL, Ballatori N. | 01/21/2010 |
| overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes | FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. | 01/21/2010 |