| CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses. | CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
Scherlinger M, Li H, Pan W, Li W, Karino K, Vichos T, Boulougoura A, Yoshida N, Tsokos MG, Tsokos GC., Free PMC Article | 02/7/2024 |
| Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses. | Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses.
Li L, Li L, Shao Y, Du R, Li L, Shi X, Bai Y., Free PMC Article | 07/6/2023 |
| CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation. | CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
Zhang Y, Daniel EA, Metcalf J, Dai Y, Reif GA, Wallace DP., Free PMC Article | 01/14/2023 |
| CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell. | CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell.
Zhang T, Li M, Zhao S, Zhou M, Liao H, Wu H, Mo X, Wang H, Guo C, Zhang H, Yang N, Huang Y., Free PMC Article | 07/2/2022 |
| Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice. | Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice.
Liu J, Li Y, Gao N, Ji J, He Q. | 03/5/2022 |
| Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis. | Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
Bhargava R, Lehoux S, Maeda K, Tsokos MG, Krishfield S, Ellezian L, Pollak M, Stillman IE, Cummings RD, Tsokos GC., Free PMC Article | 02/19/2022 |
| CaMKIV regulates mitochondrial dynamics during sepsis. | CaMKIV regulates mitochondrial dynamics during sepsis.
Zhang X, Griepentrog JE, Zou B, Xu L, Cyr AR, Chambers LM, Zuckerbraun BS, Shiva S, Rosengart MR., Free PMC Article | 09/25/2021 |
| CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis. | CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
Sabbir MG., Free PMC Article | 08/14/2021 |
| CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis. | CaMK4-dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis.
Zhan CS, Chen J, Chen J, Zhang LG, Liu Y, Du HX, Wang H, Zheng MJ, Yu ZQ, Chen XG, Zhang L, Liang CZ. | 05/1/2021 |
| CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice. | CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.
Liu J, Li Y, Zhou X, Zhang X, Meng H, Liu S, Zhang L, He J, He Q, Geng Y. | 09/19/2020 |
| results of the study indicate that the activity of CaMK4 could be responsible for glycolysis in T cells, which contributes to the production of IL-17. | Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus.
Koga T, Sato T, Furukawa K, Morimoto S, Endo Y, Umeda M, Sumiyoshi R, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Origuchi T, Nakamura H, Kawakami A. | 01/4/2020 |
| Clinical disease severity directly correlates with calmodulin-dependent kinase IV (CaMKIV) activation, as does expression of proinflammatory cytokines and histologic features of colitis. In wild-type mice, CaMKIV activation is associated with increases in expression of 2 cell cycle proarrest signals: p53 and p21 | Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.
Cunningham KE, Novak EA, Vincent G, Siow VS, Griffith BD, Ranganathan S, Rosengart MR, Piganelli JD, Mollen KP., Free PMC Article | 09/21/2019 |
| both CaMKII autophosphorylation and CaMKIV phosphorylation significantly decreased in hippocampal CA1 regions of NCKX2+/- relative to control mice. | Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice.
Moriguchi S, Kita S, Yabuki Y, Inagaki R, Izumi H, Sasaki Y, Tagashira H, Horie K, Takeda J, Iwamoto T, Fukunaga K. | 03/2/2019 |
| CaMKIV can act as an immunostimulation molecule and enhances the acute muscle inflammatory responses. | Calcium/Calmodulin-Dependent Protein Kinase IV (CaMKIV) Mediates Acute Skeletal Muscle Inflammatory Response.
Shi D, Gu R, Song Y, Ding M, Huang T, Guo M, Xiao J, Huang W, Liao H. | 09/29/2018 |
| CaMKIV knockdown selectively inhibits pro-inflammatory cytokines/chemokines, and co-stimulatory molecules expression in IFN-gamma treated myoblasts and myotubes and abolishes IFN-gamma induced CREB pathway molecules accumulation in differentiated myotubes. | Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells.
Gu R, Ding M, Shi D, Huang T, Guo M, Yu L, Hu J, Huang W, Liao H. | 06/30/2018 |
| Activation of CaMKIV by soluble amyloid-beta1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis. | Activation of CaMKIV by soluble amyloid-β(1-42) impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
Park D, Na M, Kim JA, Lee U, Cho E, Jang M, Chang S. | 04/7/2018 |
| CaMKIV is a key regulator of neuronal intracellular HDAC4 trafficking during stroke | Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke.
Yuan H, Denton K, Liu L, Li XJ, Benashski S, McCullough L, Li J. | 02/24/2018 |
| Pharmacological inhibition of CaMK4 recapitulated the observed defects in Cryptococcus neoformans phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with Cryptococcus neoformans. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize Cryptococcus neoformans. | RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis.
Srikanta D, Hole CR, Williams M, Khader SA, Doering TL., Free PMC Article | 12/16/2017 |
| results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it | Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells.
Wang G, Zhang H, Wang L, Wang Y, Huang H, Sun F., Free PMC Article | 08/13/2016 |
| CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group. | Jieduquyuziyin prescription suppresses IL-17 production and Th17 activity in MRL/lpr mice by inhibiting expression of Ca(2+)/calmodulin-dependent protein kinase-4.
Shui B, Xia W, Wen C, Ding X. | 01/30/2016 |
| Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia | Genetic deletion of calcium/calmodulin-dependent protein kinase kinase β (CaMKK β) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice.
Liu L, McCullough L, Li J., Free PMC Article | 07/25/2015 |
| CaMKIV-mTOR-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult. | CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.
Zhang X, Howell GM, Guo L, Collage RD, Loughran PA, Zuckerbraun BS, Rosengart MR., Free PMC Article | 12/20/2014 |
| CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. | CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC., Free PMC Article | 06/21/2014 |
| The stimulation of CaMKII activity in the hippocampus is essential for rivastigmine-induced memory improvement in olfactory bulbectomized mice. | CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment.
Moriguchi S, Tagashira H, Sasaki Y, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K. | 05/17/2014 |
| CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia. | Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia.
McCullough LD, Tarabishy S, Liu L, Benashski S, Xu Y, Ribar T, Means A, Li J., Free PMC Article | 11/23/2013 |