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    Camk2a calcium/calmodulin-dependent protein kinase II alpha [ Mus musculus (house mouse) ]

    Gene ID: 12322, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Loss of mitochondrial Ca[2+] response and CaMKII/ERK activation by LRRK2[R1441G] mutation correlate with impaired depolarization-induced mitophagy.

    Loss of mitochondrial Ca(2+) response and CaMKII/ERK activation by LRRK2(R1441G) mutation correlate with impaired depolarization-induced mitophagy.
    Chang EE, Liu H, Choi ZY, Malki Y, Zhang SX, Pang SY, Kung MH, Ramsden DB, Ho SL, Ho PW., Free PMC Article

    10/18/2024
    Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.

    Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.
    Anjum R, Clarke VRJ, Nagasawa Y, Murakoshi H, Paradis S., Free PMC Article

    10/11/2024
    circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.

    circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.
    Lin J, Xia H, Yu J, Wang Y, Wang H, Xie D, Cheng C, Lu L, Bian T, Wu Y, Liu Q.

    08/31/2024
    TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca[2+]/CaMKII signaling pathway.

    TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca(2+)/CaMKII signaling pathway.
    Li J, Zhang J, Zhong Y, Xie D, Han H, Zhang Z, Liu Y, Li S.

    08/31/2024
    A critical role of Ca[2+]/calmodulin-dependent protein kinase II in coupling between evening and morning circadian oscillators in the suprachiasmatic nucleus.

    A critical role of Ca(2+)/calmodulin-dependent protein kinase II in coupling between evening and morning circadian oscillators in the suprachiasmatic nucleus.
    Yoshikawa T, Honma KI, Shigeyoshi Y, Yamagata Y, Honma S.

    08/6/2024
    TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.

    TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.
    Burch AM, Garcia JD, O'Leary H, Haas A, Orfila JE, Tiemeier E, Chalmers N, Smith KR, Quillinan N, Herson PS.,

    06/5/2024
    Deletion of CaMKIIalpha disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.

    Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex.
    Andersen JV, Westi EW, Griem-Krey N, Skotte NH, Schousboe A, Aldana BI, Wellendorph P.

    05/21/2024
    Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.

    Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.
    Hell JW.

    11/10/2023
    A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.

    A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.
    Xiao K, Li Y, Chitwood RA, Magee JC., Free PMC Article

    09/12/2023
    Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.

    Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.
    Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU., Free PMC Article

    09/8/2023
    Autophosphorylation of alphaCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.

    Autophosphorylation of αCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.
    Cały A, Ziółkowska M, Pagano R, Salamian A, Śliwińska MA, Sotoudeh N, Bernaś T, Radwanska K.

    05/24/2023
    Calcium/calmodulin-dependent protein kinase IIalpha heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.

    Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.
    Featherstone RE, Shimada T, Crown LM, Melnychenko O, Yi J, Matsumoto M, Tajinda K, Mihara T, Adachi M, Siegel SJ.

    09/10/2022
    CaMKIIalpha knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest.

    CaMKIIα knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest.
    Rumian NL, Chalmers NE, Tullis JE, Herson PS, Bayer KU., Free PMC Article

    03/26/2022
    The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.

    The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.
    Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK., Free PMC Article

    03/5/2022
    Synaptic memory requires CaMKII.

    Synaptic memory requires CaMKII.
    Tao W, Lee J, Chen X, Díaz-Alonso J, Zhou J, Pleasure S, Nicoll RA., Free PMC Article

    02/19/2022
    Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts.

    Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts.
    Zhang S, Lu K, Yang S, Wu Y, Liao J, Lu Y, Wu Q, Zhao N, Dong Q, Chen L, Du Y.

    01/22/2022
    ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.

    ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.
    Eigler T, Zarfati G, Amzallag E, Sinha S, Segev N, Zabary Y, Zaritsky A, Shakked A, Umansky KB, Schejter ED, Millay DP, Tzahor E, Avinoam O., Free PMC Article

    01/15/2022
    Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.

    Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.
    Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B., Free PMC Article

    01/8/2022
    MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis.

    MLKL and CaMKII Are Involved in RIPK3-Mediated Smooth Muscle Cell Necroptosis.
    Zhou T, DeRoo E, Yang H, Stranz A, Wang Q, Ginnan R, Singer HA, Liu B., Free PMC Article

    11/27/2021
    CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2alpha Expression Independent of RIG-I Signaling.

    CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling.
    Lee YL, Kung FC, Lin CH, Huang YS., Free PMC Article

    10/23/2021
    Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of alphaCaMKII.

    Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.
    Śliwińska MA, Cały A, Borczyk M, Ziółkowska M, Skonieczna E, Chilimoniuk M, Bernaś T, Giese KP, Radwanska K.

    08/21/2021
    Convergent NMDA receptor-Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36.

    Convergent NMDA receptor-Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36.
    Siu RCF, Kotova A, Timonina K, Zoidl C, Zoidl GR., Free PMC Article

    08/14/2021
    Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.

    Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.
    Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E, Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-Armouche A, Sossalla S, Kämmerer S., Free PMC Article

    07/3/2021
    Cobalt Regulates Activation of Camk2alpha in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization.

    Cobalt Regulates Activation of Camk2α in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization.
    Duda P, Budziak B, Rakus D., Free PMC Article

    05/29/2021
    CaMKIIalpha Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge.

    CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge.
    Butt UJ, Hassouna I, Fernandez Garcia-Agudo L, Steixner-Kumar AA, Depp C, Barnkothe N, Zillmann MR, Ronnenberg A, Bonet V, Goebbels S, Nave KA, Ehrenreich H., Free PMC Article

    05/15/2021
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