| Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output. | Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice.
Benedetti B, Benedetti A, Flucher BE., Free PMC Article | 11/18/2017 |
| The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. | The juvenile myoclonic epilepsy mutant of the calcium channel β(4) subunit displays normal nuclear targeting in nerve and muscle cells.
Etemad S, Campiglio M, Obermair GJ, Flucher BE., Free PMC Article | 06/20/2015 |
| an alternatively spliced beta4 subunit of voltage-gated calcium channels lacking the variable N terminus (beta4e) is identified | Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE., Free PMC Article | 03/15/2014 |
| Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy | Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.
Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M., Free PMC Article | 12/8/2012 |
| Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus. | Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
Ferrándiz-Huertas C, Gil-Mínguez M, Luján R. | 11/24/2012 |
| The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. | The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.
Xu X, Lee YJ, Holm JB, Terry MD, Oswald RE, Horne WA., Free PMC Article | 05/21/2011 |
| Cacnb4 is associated with acute lung injury | Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.
Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA, Dietsch M, Pope-Varsalona H, Dopico RA Jr, Di YP, Li Q, Vuga LJ, Medvedovic M, Kaminski N, You M, Prows DR., Free PMC Article | 02/14/2011 |
| analysis of calcium channel beta4b subunit nuclear targeting in nerve and muscle cells | Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells.
Subramanyam P, Obermair GJ, Baumgartner S, Gebhart M, Striessnig J, Kaufmann WA, Geley S, Flucher BE., Free PMC Article | 02/8/2010 |
| neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties | Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.
Kuhn S, Knirsch M, Rüttiger L, Kasperek S, Winter H, Freichel M, Flockerzi V, Knipper M, Engel J. | 02/8/2010 |
| Paroxysmal dyskinesias as well as absence epilepsy, chronic ataxia, and hypoactivity noted in the lethargic mouse mutant with CCHB4 gene mutation | Paroxysmal dyskinesias in the lethargic mouse mutant.
Khan Z, Jinnah HA., Free PMC Article | 01/21/2010 |
| L-type calcium channel beta 2 and 4 subunits may play a major role in conferring calcium handling heterogeneity within the developing embryonic myocardium | Regional expression of L-type calcium channel subunits during cardiac development.
Acosta L, Haase H, Morano I, Moorman AF, Franco D. | 01/21/2010 |