Voltage-dependent Ca(2+) release is impaired in hypokalemic periodic paralysis caused by CaV1.1-R528H but not by NaV1.4-R669H. | Voltage-dependent Ca(2+) release is impaired in hypokalemic periodic paralysis caused by Ca(V)1.1-R528H but not by Na(V)1.4-R669H. DiFranco M, Cannon SC., Free PMC Article | 08/13/2022 |
MRTF-A regulates Ca(2+) release through CACNA1S. | MRTF-A regulates Ca(2+) release through CACNA1S. Liang C, Xu Y, Peng Z, Luo Y, Zhang T. | 12/4/2021 |
Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding. | Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding. Dayal A, Fernández-Quintero ML, Liedl KR, Grabner M., Free PMC Article | 10/23/2021 |
Divalent cations permeation in a Ca(2+) non-conducting skeletal muscle dihydropyridine receptor mouse model. | Divalent cations permeation in a Ca(2+) non-conducting skeletal muscle dihydropyridine receptor mouse model. Idoux R, Fuster C, Jacquemond V, Dayal A, Grabner M, Charnet P, Allard B. | 08/7/2021 |
Dysferlin-deficient myotubes show tethering of different membrane compartments characterized by TMEM16E and DHPRalpha. | Dysferlin-deficient myotubes show tethering of different membrane compartments characterized by TMEM16E and DHPRα. Kubozono K, Mizuta K, Fujimoto S, Tran TT, Kamata N, Tobiume K. | 02/13/2021 |
Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction. | Postsynaptic Ca(V)1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction. Kaplan MM, Flucher BE., Free PMC Article | 11/21/2020 |
CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. | CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. Sarute N, Ross SR., Free PMC Article | 10/3/2020 |
Equivalent L-type channel (CaV1.1) function in adult female and male mouse skeletal muscle fibers. | Equivalent L-type channel (Ca(V)1.1) function in adult female and male mouse skeletal muscle fibers. Beqollari D, Kohrt WM, Bannister RA., Free PMC Article | 09/5/2020 |
An embryonic CaVbeta1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. | An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. Traoré M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B, Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F, Falcone S. | 09/5/2020 |
The decrease of RyR1 protein content in total homogenates is not accompanied by a decrease of Cav1.1 content, whereby the Cav1.1/RyR1 stoichiometry ratio in skeletal muscles from RyR1Q1970fsX16 heterozygous mice is lower compared to that from WT mice | Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres. Elbaz M, Ruiz A, Eckhardt J, Pelczar P, Muntoni F, Boncompagni S, Treves S, Zorzato F. | 02/8/2020 |
we provide evidence that endogenous STAC3 incorporates into triads in the absence of the DHPR in myotubes and muscle fibers of dysgenic mice. This finding demonstrates that STAC3 interacts with additional triad proteins and is consistent with its proposed role in directly or indirectly linking the DHPR with the RyR1 | STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor. Campiglio M, Kaplan MM, Flucher BE., Free PMC Article | 09/28/2019 |
skeletal muscle L-type Ca(2+) channel with a mutation in the selectivity filter (CaV1.1 E1014K) conducts K | A skeletal muscle L-type Ca(2+) channel with a mutation in the selectivity filter (Ca(V)1.1 E1014K) conducts K<sup/>. Beqollari D, Dockstader K, Bannister RA., Free PMC Article | 01/12/2019 |
FMOD affected the expressions of the Cav1.1 and Cav3.1 genes. FMOD regulates calcium channel activity. The mRNA expressions of Cav1.1 and Cav3.1 increased during muscle regeneration. | Fibromodulin modulates myoblast differentiation by controlling calcium channel. Lee EJ, Nam JH, Choi I. | 12/22/2018 |
Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction. | Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction. Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M., Free PMC Article | 08/18/2018 |
The DHPR functions as a voltage sensor to trigger muscle contraction and as a Ca(2+) channel. | The Ca(2+) influx through the mammalian skeletal muscle dihydropyridine receptor is irrelevant for muscle performance. Dayal A, Schrötter K, Pan Y, Föhr K, Melzer W, Grabner M., Free PMC Article | 02/24/2018 |
TnT3 regulates expression of Cav1.1 in skeletal muscle, this regulation is impaired in aging. | Will you still need me (Ca(2+) , TnT, and DHPR), will you still cleave me (calpain), when I'm 64? Pinto JR, Muller-Delp J, Chase PB., Free PMC Article | 12/2/2017 |
Immunohistochemistry and western blotting after expression of GPR179 in HEK293T cells indicate that the CACNA1S antibody used here and in the retinal studies published to date, cross-reacts with GPR179. | CACNA1S expression in mouse retina: Novel isoforms and antibody cross-reactivity with GPR179. Hasan N, Ray TA, Gregg RG., Free PMC Article | 10/21/2017 |
TnT3 regulates transcription of Cacna1s, the gene encoding Cav1.1. Knocking down TnT3 in vivo downregulated Cav1.1. | Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O., Free PMC Article | 06/10/2017 |
mutating residue E4242 affects RyR1 structures critical for retrograde communication with CaV1.1 | Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1. Bannister RA, Sheridan DC, Beam KG., Free PMC Article | 12/17/2016 |
These results provide new insights into the role of muscle-specific proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling. | Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor α1S Subunit Reveals Conformational Differences Induced by Binding of the β1a Subunit. Mahalingam M, Perez CF, Fessenden JD., Free PMC Article | 12/17/2016 |
Events occurring locally in the skeletal muscle of SOD1 mutant mice contribute to the impairment of CaV1.1 function in ALS muscle independently of innervation status. | Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis. Beqollari D, Romberg CF, Dobrowolny G, Martini M, Voss AA, Musarò A, Bannister RA., Free PMC Article | 10/8/2016 |
Knockdown of Cav1.1 channels in T cells abrogated calcium entry after TCR stimulation, suggesting that Cav1.1 channels are controlled by T cell receptor signaling | T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA., Free PMC Article | 07/30/2016 |
Treatment of MSC with BMP4 caused a significant increase in expression of Cav1.2, a delay in expression of Cav1.1, and a reduction in the duration of calcium transients when extracellular calcium was removed | Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells. Grajales L, Lach LE, Janisch P, Geenen DL, García J. | 03/5/2016 |
This study delineates a previously uncharacterized CaV1.1-mediated pathway that regulates energy utilization in skeletal muscle. | Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL., Free PMC Article | 12/19/2015 |
Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. | Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Rüegg MA, Delbono O, Caputo C, Zorzato F., Free PMC Article | 04/18/2015 |