| In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function. | In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function.
Estupiñán HY, Bouderlique T, He C, Berglöf A, Cappelleri A, Frengen N, Zain R, Karlsson MCI, Månsson R, Smith CIE., Free PMC Article | 05/2/2024 |
| Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation. | Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation.
Han F, Shi X, Liao T, Zhang W, Ma M, Leng Q, Jiang W, Na N, Miao Y, Huang Z. | 03/18/2024 |
| Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae. | Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae.
Liu Z, De Porto APNA, De Beer R, Roelofs JJTH, De Boer OJ, Florquin S, Van't Veer C, Hendriks RW, Van der Poll T, De Vos AF., Free PMC Article | 01/3/2024 |
| Bruton's tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder. | Bruton's tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder.
Liu Y, Huang Z, Zhang TX, Han B, Yang G, Jia D, Yang L, Liu Q, Lau AYL, Paul F, Verkhratsky A, Shi FD, Zhang C., Free PMC Article | 01/3/2024 |
| Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction. | Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction.
Wang B, Tan Y, Zhou W, Yang J, Jiang Y, Liu X, Zhan Z. | 10/8/2022 |
| Bruton's TK regulates myeloid cell recruitment during acute inflammation. | Bruton's TK regulates myeloid cell recruitment during acute inflammation.
Purvis GSD, Aranda-Tavio H, Channon KM, Greaves DR., Free PMC Article | 05/14/2022 |
| Bruton's tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress. | Bruton's tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress.
Ghosh S, Mohammed Z, Singh I., Free PMC Article | 03/26/2022 |
| Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia. | Bruton's Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia.
de Porto AP, Liu Z, de Beer R, Florquin S, Roelofs JJTH, de Boer OJ, den Haan JMM, Hendriks RW, van 't Veer C, van der Poll T, de Vos AF., Free PMC Article | 12/25/2021 |
| Bruton's tyrosine kinase regulates macrophageinduced inflammation in the diabetic kidney via NLRP3 inflammasome activation. | Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation.
Zhao J, Chen J, Li YY, Xia LL, Wu YG., Free PMC Article | 12/25/2021 |
| BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. | BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR., Free PMC Article | 12/11/2021 |
| Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B-cell receptor signaling in mice. | Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B-cell receptor signaling in mice.
Rip J, de Bruijn MJW, Neys SFH, Singh SP, Willar J, van Hulst JAC, Hendriks RW, Corneth OBJ., Free PMC Article | 11/22/2021 |
| T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia. | T-cell expression of Bruton's tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia.
Xia S, Liu X, Cao X, Xu S., Free PMC Article | 10/2/2021 |
| Btk knockout attenuates the liver inflammation in STZ-induced diabetic mice by suppressing NLRP3 inflammasome activation. | Btk knockout attenuates the liver inflammation in STZ-induced diabetic mice by suppressing NLRP3 inflammasome activation.
Li Y, Zhao J, Wu Y, Xia L. | 09/11/2021 |
| Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1beta-mediated colitis. | Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis.
Mao L, Kitani A, Hiejima E, Montgomery-Recht K, Zhou W, Fuss I, Wiestner A, Strober W., Free PMC Article | 01/2/2021 |
| Ibrutinib suppressed phosphorylation of BTK in neutrophils at lower doses and ITK in CD4+T cells at higher doses in CE-treated mice. | Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy.
Nadeem A, Ahmad SF, Al-Harbi NO, Ibrahim KE, Siddiqui N, Al-Harbi MM, Attia SM, Bakheet SA. | 07/4/2020 |
| Study utilized B cell-specific inositol polyphosphate multikinase (IPMK)-deficient mice to investigate the role of higher order inositol phosphates (InsP6) in B cell immunity and showed that IPMK is a regulator of T cell-independent immune responses and that InsP6 confers a mechanism to regulate the activity of Bruton's tyrosine kinase (Btk) in B cell receptor signaling. | Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase.
Kim W, Kim E, Min H, Kim MG, Eisenbeis VB, Dutta AK, Pavlovic I, Jessen HJ, Kim S, Seong RH., Free PMC Article | 04/11/2020 |
| Performed crystallographic and biochemical analyses of Bruton agammaglobulinemia tyrosine kinase(Btk), which together show molecular details of its autoinhibition and activation. | Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.
Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT., Free PMC Article | 04/4/2020 |
| this study shows that Btk is required for maintaining lung vascular integrity during murine pneumococcal pneumosepsis | Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.
de Porto APNA, Claushuis TAM, van der Donk LEH, de Beer R, de Boer OJ, Florquin S, Roelofs JJTH, Hendriks RW, van der Poll T, Van't Veer C, de Vos AF. | 12/14/2019 |
| reduced activation or curtate expression of SHIP1 can be compensated by pharmacological inhibition of BTK and vice versa. | Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells.
Zorn CN, Simonowski A, Huber M., Free PMC Article | 11/23/2019 |
| this paper demonstrates distinct roles for Bruton's tyrosine kinase in B cell immune synapse formation | Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation.
Roman-Garcia S, Merino-Cortes SV, Gardeta SR, de Bruijn MJW, Hendriks RW, Carrasco YR., Free PMC Article | 10/5/2019 |
| blocking Btk specifically in the alveolar compartment led to significant attenuation of neutrophil extracellular traps released into the lung in vivo and neutrophil extracellular trap formation in vitro. | Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury.
Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK., Free PMC Article | 07/6/2019 |
| A novel role for BTK in regulating CD1d(hi)CD5(+) Breg differentiation. | BTK signaling drives CD1d(hi)CD5(+) regulatory B-cell differentiation to promote pancreatic carcinogenesis.
Das S, Bar-Sagi D., Free PMC Article | 05/25/2019 |
| CD40-mediated signals, likely from CD4 T cells, can mediate peripheral transitional B cell maturation independent of Btk and the non-canonical NF-kappaB pathway. | Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase.
Tanwar S, Dhar A, Varanasi V, Mukherjee T, Boppana R, Basak S, Bal V, George A, Rath S., Free PMC Article | 12/1/2018 |
| As chronic lymphocytic leukemia (CLL) proliferation and survival depends on the microenvironment, we used murine models to assess the efficacy of the BTK inhibitor acalabrutinib combined with the PI3Kdelta inhibitor ACP-319 in vivo.The combination of acalabrutinib and ACP-319 was superior to single-agent treatment in a murine CLL model | Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.
Niemann CU, Mora-Jensen HI, Dadashian EL, Krantz F, Covey T, Chen SS, Chiorazzi N, Izumi R, Ulrich R, Lannutti BJ, Wiestner A, Herman SEM., Free PMC Article | 07/21/2018 |
| Results show that BTK adopts a closed conformation in dynamic equilibrium with open, active conformations. BTK lacks the phosphotyrosine regulatory tail of the SRC kinases, yet nevertheless achieves a phosphotyrosine-independent C-terminal latch. The unique proline-rich region is an internal "on" switch pushing the autoinhibited kinase toward its active state. | Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.
Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH., Free PMC Article | 03/24/2018 |