| NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis. | NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.
Timón Pérez K, Scrofani J, Vernos I., Free PMC Article | 11/26/2022 |
| PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations. | PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.
Chi W, Wang G, Xin G, Jiang Q, Zhang C., Free PMC Article | 05/22/2021 |
| Authors show here that the expression of a NEDD1 isoform mimicking phosphorylation by Aurora A is sufficient to restore microtubule nucleation in the midzone under conditions of Aurora A inhibition. | Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.
Courthéoux T, Reboutier D, Vazeille T, Cremet JY, Benaud C, Vernos I, Prigent C. | 07/25/2020 |
| One important function of Aurora A in mitotic cells is to promote microtubule nucleation around the chromatin by phosphorylating NEDD1, and thereby to promote functional spindle assembly. | The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.
Pinyol R, Scrofani J, Vernos I. | 08/10/2013 |
| The mice treated with small interfering (si) RNA targeting NEDD1 by the atelocollagen-mediated delivery system showed a significantly prolonged survival in a xenograft model of human gastric cancer. | Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.
Fujita T, Yanagihara K, Takeshita F, Aoyagi K, Nishimura T, Takigahira M, Chiwaki F, Fukagawa T, Katai H, Ochiya T, Sakamoto H, Konno H, Yoshida T, Sasaki H., Free PMC Article | 07/6/2013 |
| Data suggest that the NEDD1/gamma-tubulin interaction is finely tuned by multiple phosphorylation events in the S557-S574 region and is critical for spindle assembly. | Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.
Gomez-Ferreria MA, Bashkurov M, Helbig AO, Larsen B, Pawson T, Gingras AC, Pelletier L. | 05/18/2013 |
| Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. | Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.
Sdelci S, Schütz M, Pinyol R, Bertran MT, Regué L, Caelles C, Vernos I, Roig J. | 01/12/2013 |
| a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome | A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.
Manning JA, Shalini S, Risk JM, Day CL, Kumar S., Free PMC Article | 01/15/2011 |
| Data suggest that sequential phosphorylation of Nedd1 by Cdk1 and Plk1 plays a role in targeting gamma tubulin ring complex to the centrosome by promoting the interaction of Nedd1 with the gammaTuRC component gamma-tubulin, during mitosis. | Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C. | 01/21/2010 |
| Data propose NEDD1 may be a promising target for controlling cell proliferation, in particular if targeted in combination with Plk1 inhibitors. | The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest.
Tillement V, Haren L, Roullet N, Etievant C, Merdes A., Free PMC Article | 01/21/2010 |
| FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. | FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.
Zhu H, Coppinger JA, Jang CY, Yates JR 3rd, Fang G., Free PMC Article | 01/21/2010 |
| GCP-WD (NEDD1) broadly mediates targeting of the gamma-tubulin ring complex to sites of microtubule nucleation and to the mitotic spindle, which is essential for spindle formation. | GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.
Lüders J, Patel UK, Stearns T. | 01/21/2010 |
| The NEED1 protein was characterized and its function in centriole duplication and spindle assembly determined. | NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.
Haren L, Remy MH, Bazin I, Callebaut I, Wright M, Merdes A., Free PMC Article | 01/21/2010 |