| Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice. | Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice.
Franco TM, Tavares MR, Novaes LS, Munhoz CD, Peixoto-Santos JE, Araujo RC, Donato J Jr, Bader M, Wasinski F., Free PMC Article | 02/22/2024 |
| Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors. | Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
Martins L, Amorim WW, Gregnani MF, de Carvalho Araújo R, Qadri F, Bader M, Pesquero JB., Free PMC Article | 11/7/2023 |
| In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant. | In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant.
Qin K, Xin S, Li G, Zhou K, Pan R, Chen S, Tao T, Li C, Tao J, Han RPS, Tu Y. | 02/11/2023 |
| Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model. | Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.
Gonçalves ECD, Vieira G, Gonçalves TR, Simões RR, Brusco I, Oliveira SM, Calixto JB, Cola M, Santos ARS, Dutra RC. | 08/14/2021 |
| Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists. | Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
Minville V, Mouledous L, Jaafar A, Couture R, Brouchet A, Frances B, Tack I, Girolami JP., Free PMC Article | 09/26/2020 |
| the present work reveals to date no functions described for the B2 receptor in muscle regeneration due to the control of proliferation and differentiation of muscle precursor cells. | Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation.
Alves JM, Martins AH, Lameu C, Glaser T, Boukli NM, Bassaneze V, Dariolli R, Nascimento IC, Martins PCM, de Souza HDN, Krieger JE, Casarini DE, Sales VM, Pesquero JB, Ulrich H., Free PMC Article | 07/25/2020 |
| These findings suggested that miR-204-3p may play a protective role in high glucose-induced apoptosis and dysfunction in podocytes through down-regulation of Bdkrb2. | MicroRNA-204-3p Attenuates High Glucose-Induced MPC5 Podocytes Apoptosis by Targeting Braykinin B2 Receptor.
Han X, Li Q, Wang C, Li Y. | 12/14/2019 |
| it was also demonstrated that B1R knockout mice infected presented a significant reduction of survival. However, the infection did not alter the B2R levels and localization in liver blood vessels | Malaria infection promotes a selective expression of kinin receptors in murine liver.
Ventura PDS, Carvalho CPF, Barros NMT, Martins-Silva L, Dantas EO, Martinez C, Melo PMS, Pesquero JB, Carmona AK, Nagaoka MR, Gazarini ML., Free PMC Article | 10/12/2019 |
| B1- and B2-kinin receptors govern Reactive Oxygen Species generation, while disruption of B1- and B2-kinin receptors leads to impaired cardiac dysfunction through excessive tyrosine nitration on the SERCA2 structure. | Ablation of B(1)- and B(2)-kinin receptors causes cardiac dysfunction through redox-nitroso unbalance.
Mesquita TRR, Miguel-Dos-Santos R, Jesus ICG, de Almeida GKM, Fernandes VA, Gomes AAL, Guatimosim S, Martins-Silva L, Ferreira AJ, Capettini LDSA, Pesquero JL, Lauton-Santos S. | 06/29/2019 |
| Bradykinin B2 receptor is necessary on the cellular level to induce cell proliferation and fate choice toward a neuronal lineage after physical exercise. | Bradykinin B2 receptor is essential to running-induced cell proliferation in the adult mouse hippocampus.
Wasinski F, Batista RO, Bader M, Araujo RC, Klempin F. | 06/15/2019 |
| first evidence indicating the causation between ACE DD or B2R+9bp genotype and the increased risk for diabetic nephropathy, broadening our horizon about the role of genetic modulators in this disease. | Relationship of angiotensin I-converting enzyme (ACE) and bradykinin B2 receptor (BDKRB2) polymorphism with diabetic nephropathy.
Zou H, Wu G, Lv J, Xu G. | 12/1/2018 |
| B2R signaling promotes aortic rupture within a ApoE-eficient mouse model associated with the ability to stimulate inflammatory phenotypes of neutrophils and vascular smooth muscle cells. | Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II-Infused Apolipoprotein E-Deficient Mouse.
Moran CS, Rush CM, Dougan T, Jose RJ, Biros E, Norman PE, Gera L, Golledge J. | 06/24/2017 |
| B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers. | Improvement of skin wound healing in diabetic mice by kinin B2 receptor blockade.
Desposito D, Chollet C, Taveau C, Descamps V, Alhenc-Gelas F, Roussel R, Bouby N, Waeckel L. | 03/5/2016 |
| role in nephrotoxicity induced by cisplatin therapy | Kinin B2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury.
Estrela GR, Wasinski F, Bacurau RF, Malheiros DM, Câmara NO, Araújo RC. | 05/16/2015 |
| a novel pathway by which C5aR/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity. | C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection.
Schmitz V, Almeida LN, Svensjö E, Monteiro AC, Köhl J, Scharfstein J. | 11/22/2014 |
| investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 and IL-13; data show, for the first time, that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism | IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.
Souza PP, Brechter AB, Reis RI, Costa CA, Lundberg P, Lerner UH., Free PMC Article | 10/11/2014 |
| B(2) receptor deficiency altered plasma oxidant/antioxidant balance. | Antioxidant/oxidant status and cardiac function in bradykinin B(1)- and B(2)-receptor null mice.
Delemasure S, Blaes N, Richard C, Couture R, Bader M, Dutartre P, Girolami JP, Connat JL, Rochette L. | 06/28/2014 |
| Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2) and mPGES-1 (microsomal prostaglandin E2 synthase-1). | Nicotine impairs cyclooxygenase-2-dependent kinin-receptor-mediated murine airway relaxations.
Xu Y, Cardell LO. | 04/26/2014 |
| Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids. | Bradykinin B2 receptor in the adrenal medulla of male rats and mice: glucocorticoid-dependent increase with immobilization stress.
Nostramo R, Tillinger A, Serova L, Kvetnansky R, Sabban EL. | 11/30/2013 |
| B1R and B2R receptors exert a critical role in the establishment of persistent hypersensitivity observed in an experimental autoimmune encephalomyelitis model | The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes.
Dutra RC, Bento AF, Leite DF, Manjavachi MN, Marcon R, Bicca MA, Pesquero JB, Calixto JB. | 10/26/2013 |
| Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas. | Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation.
Fang C, Stavrou E, Schmaier AA, Grobe N, Morris M, Chen A, Nieman MT, Adams GN, LaRusch G, Zhou Y, Bilodeau ML, Mahdi F, Warnock M, Schmaier AH., Free PMC Article | 06/29/2013 |
| A loss of B1 receptors markedly exacerbates the severity of dextran sulfate sodium-induced colitis in mice, which may be associated with compensatory overexpression of B2 receptors | Exacerbation of DSS-induced colitis in mice lacking kinin B(1) receptors through compensatory up-regulation of kinin B(2) receptors: the role of tight junctions and intestinal homeostasis.
Marcon R, Claudino RF, Dutra RC, Bento AF, Schmidt EC, Bouzon ZL, Sordi R, Morais RL, Pesquero JB, Calixto JB., Free PMC Article | 06/22/2013 |
| Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice. | Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.
Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG., Free PMC Article | 04/6/2013 |
| Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. | Kinin-B2 receptor activity determines the differentiation fate of neural stem cells.
Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri AR, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H., Free PMC Article | 03/30/2013 |
| Data highlighted the role of several altered pathological pathways in response to disruption of B(2)R and to the diabetic state that included. | Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes.
Jaffa MA, Kobeissy F, Al Hariri M, Chalhoub H, Eid A, Ziyadeh FN, Jaffa AA., Free PMC Article | 03/9/2013 |