| IkB Protein BCL3 as a Controller of Osteogenesis and Bone Health. | IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.
Jaffery H, Huesa C, Chilaka S, Cole J, Doonan J, Akbar M, Dunning L, Tanner KE, van 't Hof RJ, McInnes IB, Carmody RJ, Goodyear CS., Free PMC Article | 01/31/2024 |
| B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3. | B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3.
Qian G, Jiang W, Sun D, Sun Z, Chen A, Fang H, Wang J, Liu Y, Yin Z, Wei H, Fang H, Zhang X., | 11/1/2023 |
| NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii. | NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii.
Guha J, Kang B, Claudio E, Redekar NR, Wang H, Kelsall BL, Siebenlist U, Murphy PM., Free PMC Article | 11/19/2022 |
| Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. | Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1.
Hu Y, Zhang H, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X., Free PMC Article | 06/18/2022 |
| Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology. | Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology.
Carr D, Zein A, Coulombe J, Jiang T, Cabrita MA, Ward G, Daneshmand M, Sau A, Pratt MAC., Free PMC Article | 06/18/2022 |
| Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes. | Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
Ai J, Wörmann SM, Görgülü K, Vallespinos M, Zagorac S, Alcala S, Wu N, Kabacaoglu D, Berninger A, Navarro D, Kaya-Aksoy E, Ruess DA, Ciecielski KJ, Kowalska M, Demir IE, Ceyhan GO, Heid I, Braren R, Riemann M, Schreiner S, Hofmann S, Kutschke M, Jastroch M, Slotta-Huspenina J, Muckenhuber A, Schlitter AM, Schmid RM, Steiger K, Diakopoulos KN, Lesina M, Sainz B Jr, Algül H. | 10/30/2021 |
| Bcl-3 suppresses differentiation of RORgammat(+) regulatory T cells. | Bcl-3 suppresses differentiation of RORγt(+) regulatory T cells.
Tang W, Saret S, Tian R, Wang H, Claudio E, Murphy PM, Siebenlist U., Free PMC Article | 10/2/2021 |
| Bcl-3 inhibits lupus-like phenotypes in BL6/lpr mice. | Bcl-3 inhibits lupus-like phenotypes in BL6/lpr mice.
Tang W, Wang H, Tian R, Saret S, Cheon H, Claudio E, Siebenlist U. | 04/24/2021 |
| The IkappaB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. | The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.
Collins PE, Somma D, Kerrigan D, Herrington F, Keeshan K, Nibbs RJB, Carmody RJ., Free PMC Article | 04/4/2020 |
| KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells | Identification of KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells.
Otsuka K, Takehara A, Chiba N, Matsui Y., Free PMC Article | 03/23/2019 |
| a sufficient concentration of Bcl3 in mouse embryonic stem cells plays a critical role in the maintenance of pluripotency and the self-renewal. | Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription.
Kang S, Yun J, Kim DY, Jung SY, Kim YJ, Park JH, Ji ST, Jang WB, Ha J, Kim JH, Baek SH, Kwon SM., Free PMC Article | 08/18/2018 |
| Thus, we concluded that fine-tuning expression of Bcl-3 is needed for proper CD4(+) T-cell development and is required to sustain Th17-cell mediated pathology. | Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells.
Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A. | 10/21/2017 |
| Bcl-3 suppressed colorectal tumor formation: Bcl-3-deficient mice were relatively protected from DSS-induced epithelial damage and developed more polyps after AOM/DSS treatment, although polyp size was unaffected. | The B-cell tumor promoter Bcl-3 suppresses inflammation-associated colon tumorigenesis in epithelial cells.
Tang W, Wang H, Ha HL, Tassi I, Bhardwaj R, Claudio E, Siebenlist U., Free PMC Article | 09/9/2017 |
| this study implicates the intracellular protein, BCL3, as a key mediator of the IL-10-induced immunosuppressive macrophage phenotype | Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.
Chuang Y, Hung ME, Cangelose BK, Leonard JN., Free PMC Article | 07/1/2017 |
| These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF/STAT3 signaling in pluripotency maintenance. | Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naïve Pluripotency.
Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Lee ST, Hsieh PC. | 10/29/2016 |
| Bcl3 reduces the inflammatory response in pancreas/biliary tissue by blocking ubiquitination and proteasome-mediated degradation of nuclear factor-kappaB p50 homodimers. | BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.
Song L, Wörmann S, Ai J, Neuhöfer P, Lesina M, Diakopoulos KN, Ruess D, Treiber M, Witt H, Bassermann F, Halangk W, Steiner JM, Esposito I, Rosendahl J, Schmid RM, Riemann M, Algül H. | 06/4/2016 |
| Low expression of IL-6 and TNF-alpha correlates with the presence of the nuclear regulators of NF-kappaB, IkappaBNS and BCL-3, in the uterus of mice. | Low expression of IL-6 and TNF-α correlates with the presence of the nuclear regulators of NF-κB, IκBNS and BCL-3, in the uterus of mice.
Sierra-Mondragón E, Gómez-Chávez F, Murrieta-Coxca M, Vázquez-Sánchez EA, Martínez-Torres I, Cancino-Díaz ME, Rojas-Espinosa O, Cancino-Díaz JC, Reyes-Sánchez JL, Rodríguez-Muñóz R, Rodríguez-Martínez S. | 01/30/2016 |
| These findings demonstrate that Bcl-3 is required in dendritic cells to prime protective T-cell-mediated immunity to T. gondii | Adaptive immune-mediated host resistance to Toxoplasma gondii is governed by the NF-κB regulator Bcl-3 in dendritic cells.
Tassi I, Claudio E, Wang H, Tang W, Ha HL, Saret S, Sher A, Jankovic D, Siebenlist U., Free PMC Article | 09/26/2015 |
| data show that BCL-3 makes extensive contacts with p50 homodimers and in particular with ankyrin repeats (ANK) 1, 6, and 7, and the N-terminal region of Bcl-3. | Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor κB (NF-κB) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide.
Collins PE, Grassia G, Colleran A, Kiely PA, Ialenti A, Maffia P, Carmody RJ., Free PMC Article | 08/29/2015 |
| The presence of a p50/Bcl-3 complex in nuclear extracts from cells of metastatic lung tissues. | Involvement of the NF-кB/p50/Bcl-3 complex in response to antiangiogenic therapy in a mouse model of metastatic renal cell carcinoma.
de Souza Braga M, da Silva Paiva KB, Foguer K, Barbosa Chaves KC, de Sá Lima L, Scavone C, Bellini MH. | 08/1/2015 |
| In SOD1 and Neurotomized mice the results of this studysuggest LC3, Fn14, Bcl3 and Gadd45a as candidate genes involved in the maintenance of the severe atrophic state. | Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
Ferry A, Joanne P, Hadj-Said W, Vignaud A, Lilienbaum A, Hourdé C, Medja F, Noirez P, Charbonnier F, Chatonnet A, Chevessier F, Nicole S, Agbulut O, Butler-Browne G. | 07/25/2015 |
| These findings identify Bcl-3 as a critical player during the later stage of the contact hypersensitivity reaction to limit inflammation via actions in radioresistant cells, including keratinocytes. | The NF-κB regulator Bcl-3 modulates inflammation during contact hypersensitivity reactions in radioresistant cells.
Tassi I, Rikhi N, Claudio E, Wang H, Tang W, Ha HL, Saret S, Kaplan DH, Siebenlist U., Free PMC Article | 06/20/2015 |
| The results expose a previously unidentified function for Bcl-3 in dendritic cell survival and the generation of adaptive immunity. | The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.
Tassi I, Claudio E, Wang H, Tang W, Ha HL, Saret S, Ramaswamy M, Siegel R, Siebenlist U., Free PMC Article | 03/7/2015 |
| Bcl-3 constrained Th1 cell plasticity and promoted pathogenicity by blocking conversion to Th17-like cells, revealing a unique type of regulation that shapes adaptive immunity. | The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Tang W, Wang H, Claudio E, Tassi I, Ha HL, Saret S, Siebenlist U., Free PMC Article | 01/10/2015 |
| This study demonstrates that interaction with p50 is necessary and sufficient for the anti-inflammatory properties of Bcl-3 and further highlights the importance of p50 homodimer stability in the control of NF-kappaB target gene expression. | Inhibition of transcription by B cell Leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50.
Collins PE, Kiely PA, Carmody RJ., Free PMC Article | 06/28/2014 |