| BChE strongly affects fat metabolism, has an important impact on fat accumulation and may be a promising tool for combating obesity. | Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.
Chen VP, Gao Y, Geng L, Stout MB, Jensen MD, Brimijoin S., Free PMC Article | 06/3/2017 |
| the absence of BChE leads to diminished fibrillar Abeta deposition in amygdala, hippocampal formation, thalamus and basal ganglia. | Reduced fibrillar β-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model.
Darvesh S, Reid GA. | 02/4/2017 |
| It was concluded that in adult murine bone the role of BChE is limited to bone specific changes in microarchitecture and to an increase in relative number of bone resorbing osteoclasts. | Bone status of adult female butyrylcholinesterase gene-deficient mice.
Haupt M, Kauschke V, Sender J, Kampschulte M, Kovtun A, Dürselen L, Heiss C, Lips KS. | 09/17/2016 |
| Mice that had undergone gene transfer with mouse CocH (mCocH) showed no place preference or aversion after repeated treatments with a near-lethal 80 mg/kg cocaine dose. | Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase.
Murthy V, Geng L, Gao Y, Zhang B, Miller JD, Reyes S, Brimijoin S., Free PMC Article | 04/23/2016 |
| we conclude that toxoplasmosis reduces BChE activity in mice, and this alteration is probably related to the liver damage caused by the parasitism | Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii.
Da Silva AS, Tonin AA, Thorstenberg ML, Leal DB, Fighera R, Flores MM, França RT, Camillo G, Vogel FS, de la Rue M, Lopes ST. | 08/31/2013 |
| Ex vivo autoradiograms, after intravenous injection with a BuChE radioligand, demonstrate increased accumulation of radioactivity especially in cortical regions in the AD mouse. | Butyrylcholinesterase radioligands to image Alzheimer's disease brain.
Darvesh S. | 06/1/2013 |
| For metacarb and isocarb, inhibition of BChE w.t. was 260 and 35 times, respectively, faster than inhibition of AChE w.t. For four mutants inhibition was faster than for AChE w.t. but none reached the inhibition rate of BChE. | Peripheral site and acyl pocket define selective inhibition of mouse butyrylcholinesterase by two biscarbamates.
Bosak A, Smilović IG, Stimac A, Vinković V, Sinko G, Kovarik Z. | 03/23/2013 |
| The localization of BChE in the secondary folds of the neuromuscular junction suggests that this enzyme is not a strict surrogate of AChE and that the two enzymes have two different roles. | Localization of butyrylcholinesterase at the neuromuscular junction of normal and acetylcholinesterase knockout mice.
Blondet B, Carpentier G, Ferry A, Chatonnet A, Courty J., Free PMC Article | 01/1/2011 |
| The effects of porphyrinogenic drugs on the brain cholinergic system (Ache, Bche, and Chrm1 levels in various regions of the brain) were examined to establish a mechanism for neurological syndrome displayed in acute porphyrias. | The effects of some porphyrinogenic drugs on the brain cholinergic system.
Rodriguez JA, Buzaleh AM, Fossati M, Azcurra J, Batlle AM. | 01/21/2010 |
| The BChE knockout mouse will allow us to test the hypothesis that the function of BChE is to detoxify poisons and will allow testing the role of BChE in other physiological functions. | Production of the butyrylcholinesterase knockout mouse.
Li B, Duysen EG, Saunders TL, Lockridge O. | 01/21/2010 |
| A possible mechanism for partial compensation of tetanic fade in acetylcholinesterase knockout mice is hydrolysis of acetylcholine by normal levels of endogenous butyrylcholinesterase. | Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice.
Adler M, Manley HA, Purcell AL, Deshpande SS, Hamilton TA, Kan RK, Oyler G, Lockridge O, Duysen EG, Sheridan RE. | 01/21/2010 |