| Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses. | Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Gottschling C, Wegrzyn D, Denecke B, Faissner A., Free PMC Article | 10/31/2020 |
| Brevican expression in the auditory cortex is upregulated during consolidation of long-term memories. | Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories.
Niekisch H, Steinhardt J, Berghäuser J, Bertazzoni S, Kaschinski E, Kasper J, Kisse M, Mitlöhner J, Singh JB, Weber J, Frischknecht R, Happel MFK., Free PMC Article | 07/4/2020 |
| Genetic deletion of brevican, one of the main components, resulted in a massive degradation of extracellular matrix baskets at inner hair cells, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing. | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets.
Sonntag M, Blosa M, Schmidt S, Reimann K, Blum K, Eckrich T, Seeger G, Hecker D, Schick B, Arendt T, Engel J, Morawski M., Free PMC Article | 05/4/2019 |
| intrachromosomal deletion generating a fusion between BCAN and NTRK1 drives the formation of aggressive high-grade gliomas and confers sensitivity to entrectinib | Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
Cook PJ, Thomas R, Kannan R, de Leon ES, Drilon A, Rosenblum MK, Scaltriti M, Benezra R, Ventura A., Free PMC Article | 12/22/2018 |
| The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack brevican, the informational content stored by synaptic plasticity is not the same. | Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.
Jansen S, Gottschling C, Faissner A, Manahan-Vaughan D. | 02/3/2018 |
| This study found that mice with reduced brevican levels show enhanced locomotor activity to acute cocaine and a progressive increase in expression of cocaine CPP during forced abstinence. | The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference.
Lubbers BR, Matos MR, Horn A, Visser E, Van der Loo RC, Gouwenberg Y, Meerhoff GF, Frischknecht R, Seidenbecher CI, Smit AB, Spijker S, van den Oever MC., Free PMC Article | 01/6/2018 |
| The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held | The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.
Blosa M, Sonntag M, Jäger C, Weigel S, Seeger J, Frischknecht R, Seidenbecher CI, Matthews RT, Arendt T, Rübsamen R, Morawski M., Free PMC Article | 07/30/2016 |
| This study provided evidence that the brevican modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs. | Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.
Geissler M, Gottschling C, Aguado A, Rauch U, Wetzel CH, Hatt H, Faissner A., Free PMC Article | 07/6/2013 |
| these results imply that Bral2-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets | Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum.
Bekku Y, Saito M, Moser M, Fuchigami M, Maehara A, Nakayama M, Kusachi S, Ninomiya Y, Oohashi T. | 08/18/2012 |
| defective brevican processing observed in amyloid beta-bearing mice may contribute to deficient neural plasticity | Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.
Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE., Free PMC Article | 05/10/2010 |
| Results indicate that reactive gliosis differs between the spinal cord dorsal root entry zone and dorsal column and that Brevican and Versican may participate in the inhibitory properties of the dorsal root entry zone. | Differential proteoglycan expression in two spinal cord regions after dorsal root injury.
Waselle L, Quaglia X, Zurn AD. | 04/12/2010 |
| This study show that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes. | Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.
Bekku Y, Rauch U, Ninomiya Y, Oohashi T. | 01/21/2010 |
| The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility | The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
Hu B, Kong LL, Matthews RT, Viapiano MS., Free PMC Article | 01/21/2010 |
| Brevican and the ADAMTS-cleaved fragment of brevican were most broadly distributed in neuropil in the brain. | Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain.
Ajmo JM, Eakin AK, Hamel MG, Gottschall PE., Free PMC Article | 01/21/2010 |
| Brevican is not essential for learning and memory, but plays a role in long-term potentiation in mice | Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Brakebusch C, Seidenbecher CI, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Böckers TM, Zhou X, Kreutz MR, Montag D, Gundelfinger ED, Fässler R., Free PMC Article | 01/21/2010 |