| Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction. | Axin2 depletion in macrophages alleviated senescence and increased immune response after myocardial infarction.
Zheng Y, Wang Y, Qi B, Gao W, Liu Y, Li T. | 02/26/2024 |
| Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer. | Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer.
Cheng LZ, Huang DL, Tang ZR, Zhang JH, Xiong T, Zhou C, Zhang NX, Fu R, Cheng YX, Wu ZQ. | 11/22/2023 |
| miR-15b-5p transcription mediated by CREB1 protects against inflammation and apoptosis in Parkinson disease models by inhibiting AXIN2 and activating Wnt/beta-catenin. | miR-15b-5p transcription mediated by CREB1 protects against inflammation and apoptosis in Parkinson disease models by inhibiting AXIN2 and activating Wnt/β-catenin.
Liu T, Li G. | 11/22/2023 |
| ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy. | ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Zhai J, Chen H, Wong CC, Peng Y, Gou H, Zhang J, Pan Y, Chen D, Lin Y, Wang S, Kang W, To KF, Chen Z, Nie Y, He HH, Sung JJ, Yu J. | 07/25/2023 |
| Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells. | Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells.
Xu C, Xie X, Shi P, Wu Y, Wang J. | 07/13/2023 |
| BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p. | BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.
Duan J, Li H, Wang C, Yao J, Jin Y, Zhao J, Zhang Y, Liu M, Sun H. | 06/19/2023 |
| Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders. | Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders.
Wang M, Xian P, Zheng W, Li Z, Chen A, Xiao H, Xu C, Wang F, Mao H, Meng H, Zhao Y, Luo C, Wang Y, Wu S., Free PMC Article | 06/13/2023 |
| Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development. | Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Sun XL, Chen ZH, Guo X, Wang J, Ge M, Wong SZH, Wang T, Li S, Yao M, Johnston LA, Wu QF. | 05/13/2023 |
| Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis. | Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis.
de Roo JJD, Chhatta A, Garcia-Perez L, Naber BAE, Vloemans SA, Salvatori DCF, Pike-Overzet K, Mikkers H, Staal FJT., Free PMC Article | 10/8/2022 |
| Axin2-expressing cells in the periodontal ligament are regulated by bone morphogenetic protein signalling and play a pivotal role in periodontium development. | Axin2-expressing cells in the periodontal ligament are regulated by bone morphogenetic protein signalling and play a pivotal role in periodontium development.
Xie X, Xu C, Zhao L, Wu Y, Feng JQ, Wang J. | 08/20/2022 |
| Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury. | Axin2-expressing cells execute regeneration after skeletal injury.
Ransom RC, Hunter DJ, Hyman S, Singh G, Ransom SC, Shen EZ, Perez KC, Gillette M, Li J, Liu B, Brunski JB, Helms JA., Free PMC Article | 05/5/2018 |
| identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling. | Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.
Maruyama T, Jiang M, Abbott A, Yu HI, Huang Q, Chrzanowska-Wodnicka M, Chen EI, Hsu W., Free PMC Article | 04/28/2018 |
| increased mesenchymal Wnt signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 antagonistic interactions modulate the level of mesenchymal Wnt/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 mutations | Mesenchymal Wnt/β-catenin signaling limits tooth number.
Järvinen E, Shimomura-Kuroki J, Balic A, Jussila M, Thesleff I. | 04/7/2018 |
| we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM) containing knockout serum replacement (KSR) exhibited higher levels of expression of axin2, a Wnt target gene, than those grown in chemically defined medium | Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture.
Sakakura E, Eiraku M, Takata N. | 12/30/2017 |
| Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals. | Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.
Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R., Free PMC Article | 12/16/2017 |
| Axin2 limits Wnt/beta-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/beta-catenin signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease. | Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease.
Hulin A, Moore V, James JM, Yutzey KE., Free PMC Article | 10/7/2017 |
| Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers | Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers.
Huraskin D, Eiber N, Reichel M, Zidek LM, Kravic B, Bernkopf D, von Maltzahn J, Behrens J, Hashemolhosseini S. | 09/9/2017 |
| Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt/beta-catenin pathway. | Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.
Alldredge A, Fuhrmann S., Free PMC Article | 05/27/2017 |
| The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis | Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.
Takase HM, Nusse R., Free PMC Article | 08/13/2016 |
| Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling. | Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling.
Lim X, Tan SH, Yu KL, Lim SB, Nusse R., Free PMC Article | 08/13/2016 |
| Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation. | Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration.
Lee SH, Johnson DT, Luong R, Yu EJ, Cunha GR, Nusse R, Sun Z., Free PMC Article | 08/6/2016 |
| Axin1 and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt/beta-catenin signalling to maintain proliferation and contribute to controlling timely myogenic differentiation. | Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function.
Figeac N, Zammit PS. | 02/27/2016 |
| These data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation. | Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.
McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ., Free PMC Article | 04/4/2015 |
| implants lacking primary stability undergo osseointegration, provided Wnt signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement. | Improving oral implant osseointegration in a murine model via Wnt signal amplification.
Mouraret S, Hunter DJ, Bardet C, Popelut A, Brunski JB, Chaussain C, Bouchard P, Helms JA., Free PMC Article | 12/6/2014 |
| Axin2(-/-) PF-sutures lack physiological endochondral ossification | Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(-/-) mice.
Behr B, Longaker MT, Quarto N., Free PMC Article | 03/22/2014 |