| Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease. | Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Gaudet ID, Xu H, Gordon E, Cannestro GA, Lu ML, Wei J., Free PMC Article | 03/4/2024 |
| Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. | Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
Huang T, Zhou J, Wang B, Wang X, Xiao W, Yang M, Liu Y, Wang Q, Xiang Y, Lan X., Free PMC Article | 01/16/2024 |
| SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation. | SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Eom J, Choi J, Suh SS, Seo JB., Free PMC Article | 01/11/2023 |
| Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A. | Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
Zheng R, da Rosa G, Dans PD, Peluffo RD. | 03/28/2021 |
| Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis. | Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
Lee J, Lee SG, Kim KK, Lim YJ, Choi JA, Cho SN, Park C, Song CH., Free PMC Article | 10/3/2020 |
| In wild-type mice exposed to hyperoxia, the exhaled nitric oxide (exNO) was twofold greater than in wild-type mice exposed to normoxia ( P < 0.005), whereas in slc7a2(-/-) mice there was no significant difference between exNO in animals exposed to hyperoxia or normoxia ( P = 0.95). These results are consistent with our hypothesis that lack of CAT-2 protects mice from acute lung injury. | Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.
Jin Y, Liu Y, Nelin LD., Free PMC Article | 02/22/2020 |
| data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk. | Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT., Free PMC Article | 03/2/2019 |
| A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet. | MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Di Pasqua LG, Berardo C, Rizzo V, Richelmi P, Croce AC, Vairetti M, Ferrigno A. | 02/4/2017 |
| In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity. | Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
Cimen Bozkus C, Elzey BD, Crist SA, Ellies LG, Ratliff TL., Free PMC Article | 03/19/2016 |
| demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression | Dynamical analysis of mCAT2 gene models with CTN-RNA nuclear retention.
Wang Q, Zhou T. | 10/3/2015 |
| cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis | Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response.
Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT., Free PMC Article | 10/19/2013 |
| These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection. | Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.
Sans-Fons MG, Yeramian A, Pereira-Lopes S, Santamaría-Babi LF, Modolell M, Lloberas J, Celada A. | 06/29/2013 |
| CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice. | Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.
Ramachandran J, Schneider JS, Crassous PA, Zheng R, Gonzalez JP, Xie LH, Beuve A, Fraidenraich D, Peluffo RD., Free PMC Article | 02/9/2013 |
| CAT2 is an important regulator of the immune response during H. pylori infection. | Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.
Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT., Free PMC Article | 09/1/2012 |
| Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair. | L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution.
Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KT., Free PMC Article | 06/30/2012 |
| Results identify CAT2 as a regulator of fibrotic responses in the lung. | The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis.
Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N., Free PMC Article | 09/27/2010 |
| By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity. | Cationic amino acid transporter-2 regulates immunity by modulating arginase activity.
Thompson RW, Pesce JT, Ramalingam T, Wilson MS, White S, Cheever AW, Ricklefs SM, Porcella SF, Li L, Ellies LG, Wynn TA., Free PMC Article | 01/21/2010 |
| CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung. | CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-gamma activity.
Chen H, Macleod C, Deng B, Mason L, Kasaian M, Goldman S, Wolf S, Williams C, Bowman MR. | 01/21/2010 |
| These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses. | Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG, Zimmermann N., Free PMC Article | 01/21/2010 |
| The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS. | Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells.
Cui Z, Tuladhar R, Hart SL, Marber MS, Pearson JD, Baydoun AR. | 01/21/2010 |
| We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell. | Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.
Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, Zorzano A, Modolell M, Celada A, Palacín M, Bertran J. | 01/21/2010 |
| Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages. | Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.
Yeramian A, Martin L, Serrat N, Arpa L, Soler C, Bertran J, McLeod C, Palacín M, Modolell M, Lloberas J, Celada A. | 01/21/2010 |
| SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation. | Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.
Yeramian A, Martin L, Arpa L, Bertran J, Soler C, McLeod C, Modolell M, Palacín M, Lloberas J, Celada A. | 01/21/2010 |
| IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity. | Interleukin-10 inhibition of nitric oxide biosynthesis involves suppression of CAT-2 transcription.
Huang CJ, Stevens BR, Nielsen RB, Slovin PN, Fang X, Nelson DR, Skimming JW. | 01/21/2010 |