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    GSTO2 glutathione S-transferase omega 2 [ Homo sapiens (human) ]

    Gene ID: 119391, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.

    The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.
    Pavlovic D, Ristic S, Djukanovic L, Matic M, Kovacevic M, Pljesa-Ercegovac M, Hadzi-Djokic J, Savic-Radojevic A, Djukic T., Free PMC Article

    01/28/2023
    Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.

    Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
    Sobot V, Stamenkovic M, Simic T, Jerotic D, Djokic M, Jaksic V, Bozic M, Milic J, Savic-Radojevic A, Djukic T.

    02/12/2022
    Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma.

    Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma.
    Sumiya R, Terayama M, Hagiwara T, Nakata K, Sekihara K, Nagasaka S, Miyazaki H, Igari T, Yamada K, Kawamura YI., Free PMC Article

    01/15/2022
    Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.

    Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
    Baba SM, Shah ZA, Pandith AA, Geelani SA, Mir MM, Bhat JR, Gul A, Bhat GM.

    12/4/2021
    Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men.

    Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men.
    Fan Z, Jiang H, Song X, Guo Y, Tian X., Free PMC Article

    07/31/2021
    Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional down-regulation of beta-catenin in human esophageal squamous cells.

    Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional down-regulation of β-catenin in human esophageal squamous cells.
    Terayama M, Yamada K, Hagiwara T, Inazuka F, Sezaki T, Igari T, Yokoi C, Nohara K, Soma D, Dohi T, Kawamura YI.

    02/6/2021
    GSTO2 variant showed lower values of induced DNA damage in chronic kidney disease.

    Levels of DNA damage (Micronuclei) in patients suffering from chronic kidney disease. Role of GST polymorphisms.
    Pastor S, Rodríguez-Ribera L, Corredor Z, da Silva Filho MI, Hemminki K, Coll E, Försti A, Marcos R.

    06/15/2019
    No direct association between different genotypes and the alleles of the GSTO1 and GSTO2 genes and risk of ischemic stroke in a Turkish population.

    Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
    Bilgin E, Can Demirdöğen B, Türkanoğlu Özçelik A, Demirkaya Ş, Adalı O.

    03/9/2019
    the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC, is reported.

    Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma.
    Radic TM, Coric VM, Pljesa-Ercegovac MS, Basta-Jovanovic GM, Radojevic-Skodric SM, Dragicevic DP, Matic MG, Bogdanovic LM, Dzamic ZM, Simic TP, Savic-Radojevic AR.

    12/22/2018
    Results showed that the variants of rs156697 and rs2297235 of GSTO2 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.

    Association between arsenic metabolism gene polymorphisms and arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.
    Luo L, Li Y, Gao Y, Zhao L, Feng H, Wei W, Qiu C, He Q, Zhang Y, Fu S, Sun D., Free PMC Article

    11/24/2018
    GSTO2 genetic polymorphisms are not associated with the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

    Association of GSTO2 (N142D), GSTT1, and GSTM1 Polymorphisms With Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
    Khosravi M, Izaddoust M, Saadat I, Karimi MH, Ramzi M.

    08/19/2017
    The GSTO2 rs2297235 "AG" genotype is associated to SCA2 but failed to show any association with clinical markers, with the exception of a potential association with the age at disease onset.

    Association of glutathione S-transferase omega polymorphism and spinocerebellar ataxia type 2.
    Almaguer-Mederos LE, Almaguer-Gotay D, Aguilera-Rodríguez R, González-Zaldívar Y, Cuello-Almarales D, Laffita-Mesa J, Vázquez-Mojena Y, Zayas-Feria P, Rodríguez-Labrada R, Velázquez-Pérez L, MacLeod P.

    06/3/2017
    GSTO2 genetic polymorphisms are associated with the progression of HBV infection.

    Distribution of Glutathione S-Transferase Omega Gene Polymorphism with Different Stages of HBV Infection Including Hepatocellular Carcinoma in the Egyptian Population.
    Shaban NZ, Salem HH, Elsadany MA, Ali BA, Hassona EM, Mogahed FA.

    01/28/2017
    The present study found that rs3740400 in As3MT and rs156697 in GSTO2 were strongly associated with the arsenic species (%iAs, %MMA and MMA/iAs and DMA/MMA ratios) in urine of the occupationally exposed workers and they may influence methylation capacity.

    Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers.
    Janasik B, Reszka E, Stanislawska M, Wieczorek E, Fendler W, Wasowicz W., Free PMC Article

    04/23/2016
    No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 N142D polymorphisms.

    Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
    Rezazadeh D, Moradi MT, Kazemi A, Mansouri K.

    04/16/2016
    GSTO2 and GSTP1 gene polymorphisms may serve as independent prognostic markers for hepatocellular carcinoma patients.

    Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients.
    Qu K, Liu SS, Wang ZX, Huang ZC, Liu SN, Chang HL, Xu XS, Lin T, Dong YF, Liu C., Free PMC Article

    01/30/2016
    Our results indicate that GSTO1*C/GSTO2*G haplotype is associated with increased risk of TCC. The modifying effect of GSTO2*G/G genotype on individual susceptibility to TCC is more pronounced, when associated with smoking.

    GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder.
    Djukic T, Simic T, Radic T, Matic M, Pljesa-Ercegovac M, Suvakov S, Coric V, Pekmezovic T, Novakovic I, Dragicevic D, Savic-Radojevic A.

    12/19/2015
    we for the first time provided evidence supporting the prognostic role of GSTO2 in the progression of TACE-treated hepatocellular carcinoma

    Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma.
    Wang Z, Qu K, Huang Z, Xu X, Zhang J, Zhang L, Liu S, Chang H, Lin T, Liu Y, Niu W, Liu C.

    11/21/2015
    The GSTA1*-69T and GSTO2*D142 variants are both associated with a significantly increased risk of asthma.

    GSTA1*-69C/T and GSTO2*N142D as asthma- and allergy-related risk factors in Italian adult patients.
    Piacentini S, Polimanti R, Iorio A, Cortesi M, Papa F, Rongioletti M, Liumbruno GM, Manfellotto D, Fuciarelli M.

    11/22/2014
    The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.

    Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation.
    Stamenkovic M, Radic T, Stefanovic I, Coric V, Sencanic I, Pljesa-Ercegovac M, Matic M, Jaksic V, Simic T, Savic-Radojevic A.

    09/27/2014
    GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.

    Glutathione S-transferase T1, O1 and O2 polymorphisms are associated with survival in muscle invasive bladder cancer patients.
    Djukic TI, Savic-Radojevic AR, Pekmezovic TD, Matic MG, Pljesa-Ercegovac MS, Coric VM, Radic TM, Suvakov SR, Krivic BN, Dragicevic DP, Simic TP., Free PMC Article

    07/5/2014
    No significant association between GSTO2 polymorphism and acute renal graft rejection.

    Influence of GSTO2 (N142D) genetic polymorphism on acute renal rejection.
    Nekooie-Marnany N, Saadat I, Karimi MH, Roozbeh J, Saadat M.

    03/1/2014
    Variants in human GSTO2 could increase disease risk susceptibility and could act as a risk factor for hypothyroidism in Italian patients.

    GSTO2*N142D gene polymorphism associated with hypothyroidism in Italian patients.
    Piacentini S, Monaci PM, Polimanti R, Manfellotto D, Fuciarelli M.

    06/22/2013
    The frequencies of GSTO1 and GSTO2 genotypes were not significantly different between head and neck squamous cell carcinoma cases and controls.

    Association of glutathione S-transferase omega gene polymorphisms with progression of head and neck cancer.
    Sanguansin S, Petmitr S, O-Charoenrat P, Pongstaporn W.

    04/6/2013
    The polymorphisms of GSTM1 and GSTO2 along with the work place influence may act additively for developing cataract.

    Association between cataract and genetic polymorphisms of GSTM1, GSTT1, and GSTO2 with respect of work place.
    Saadat I, Ahmadi Z, Farvardin-Jahromi M, Saadat M., Free PMC Article

    12/22/2012
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