| SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA. | SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA.
Fang H, Xie A, Du M, Li X, Yang K, Fu Y, Yuan X, Fan R, Yu W, Zhou Z, Sang T, Nie K, Li J, Zhao Q, Chen Z, Yang Y, Hong C, Lyu J. | 05/7/2022 |
| Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice. | Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice.
Nogami K, Maruyama Y, Sakai-Takemura F, Motohashi N, Elhussieny A, Imamura M, Miyashita S, Ogawa M, Noguchi S, Tamura Y, Kira JI, Aoki Y, Takeda S, Miyagoe-Suzuki Y., Free PMC Article | 03/5/2022 |
| Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight. | Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight.
Braun JL, Geromella MS, Hamstra SI, Messner HN, Fajardo VA., Free PMC Article | 12/25/2021 |
| Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells. | Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.
Kakizawa S, Kishimoto Y, Yamamoto S, Onga K, Yasuda K, Miyamoto Y, Watanabe M, Sakai R, Mori N., Free PMC Article | 02/27/2021 |
| it may be profoundly antiarrhythmic. This may be clinically relevant when therapies are applied to stimulate the SERCA activity (e.g. SERCA overexpression with gene therapy, future small molecule SERCA stimulators). | Stabilization of Ca(2+) signaling in cardiac muscle by stimulation of SERCA.
Fernandez-Tenorio M, Niggli E. | 09/21/2019 |
| Our results indicate that the phospholipid headgroup PC:PE negatively correlated and could potentially contribute to reductions in SERCA activity seen in functionally overloaded plantaris. | Elevated whole muscle phosphatidylcholine: phosphatidylethanolamine ratio coincides with reduced SERCA activity in murine overloaded plantaris muscles.
Fajardo VA, Mikhaeil JS, Leveille CF, Tupling AR, LeBlanc PJ., Free PMC Article | 09/22/2018 |
| CAPN3 deficiency leads to degradation of SERCA proteins and Ca2+ dysregulation in the skeletal muscle. | Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Toral-Ojeda I, Aldanondo G, Lasa-Elgarresta J, Lasa-Fernández H, Fernández-Torrón R, López de Munain A, Vallejo-Illarramendi A., Free PMC Article | 10/22/2016 |
| Ebf3 binds directly to the promoter of Atp2a1 and synergises with MyoD in the induction of Atp2a1 | Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.
Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. | 02/20/2016 |
| Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1-independent mechanism that may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation. | Formalin evokes calcium transients from the endoplasmatic reticulum.
Fischer MJ, Soller KJ, Sauer SK, Kalucka J, Veglia G, Reeh PW., Free PMC Article | 01/16/2016 |
| SERCA1b is considered to play an essential role in the regulation of [Ca2+]i and its ab ovo gene silencing results in decreased skeletal muscle differentiation. | The Effect of SERCA1b Silencing on the Differentiation and Calcium Homeostasis of C2C12 Skeletal Muscle Cells.
Tóth A, Fodor J, Vincze J, Oláh T, Juhász T, Zákány R, Csernoch L, Zádor E., Free PMC Article | 01/16/2016 |
| Data show that in healthy transgenic mice, cardiac-specific sarcoplasmic reticulum calcium ATPase SERCA1a expression increased active cell-surface glucose transporter GLUT4 and glucose uptake in the myocardium. | Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.
Waller AP, Kalyanasundaram A, Hayes S, Periasamy M, Lacombe VA. | 10/3/2015 |
| Data suggest that the cardiac depressant properties of neuronostatin possibly associated with loss of sarcoplasmic reticulum Ca2+-ATPase SERCA phosphorylation. | Neuronostatin attenuates myocardial contractile function through inhibition of sarcoplasmic reticulum Ca2+-ATPase in murine heart.
Zhu X, Hu N, Chen X, Zhu MZ, Dong H, Xu X, Luo F, Hua Y, Nair S, Samson WK, Xiong L. | 09/26/2015 |
| Results indicated that sine oculis homeobox 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl, and Mylpf. | Overexpression of Six1 gene suppresses proliferation and enhances expression of fast-type muscle genes in C2C12 myoblasts.
Wu W, Ren Z, Zhang L, Liu Y, Li H, Xiong Y. | 02/8/2014 |
| Protein levels of CSQ1, SERCA1, and SERCA2 are re-adjusted in skeletal muscles depending on the demands of diverse exercise training programs. | Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle.
Kinnunen S, Mänttäri S. | 09/8/2012 |
| dystrophic phenotype observed in delta-sarcoglycan-null (Sgcd(-/-)) mice and dystrophin mutant mdx mice is dramatically improved by skeletal muscle-specific overexpression of sarcoplasmic reticulum Ca(2+) ATPase 1 (SERCA1) | Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.
Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD., Free PMC Article | 04/30/2011 |
| In dystrophin-deficient mdx mice the serca1 is overpression in laryngeal muscles. | Sarcoplasmic-endoplasmic-reticulum Ca2+-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficient mdx mice.
Ferretti R, Marques MJ, Pertille A, Santo Neto H. | 01/21/2010 |
| Sarcolipin is a novel regulator of SERCA pump activity, and its inhibitory effect can be reversed by beta-adrenergic agonists. | Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
Babu GJ, Bhupathy P, Petrashevskaya NN, Wang H, Raman S, Wheeler D, Jagatheesan G, Wieczorek D, Schwartz A, Janssen PM, Ziolo MT, Periasamy M. | 01/21/2010 |
| The results indicate that SERCA overexpression can reduce the *OH-induced contractile dysfunction in murine myocardium, whereas a reduced SR Ca(2+)-ATPase activity aggravates this injury. | SERCA overexpression reduces hydroxyl radical injury in murine myocardium.
Hiranandani N, Bupha-Intr T, Janssen PM. | 01/21/2010 |
| Our studies point to an important regulation of SERCA1b expression at the protein level and hints to a role in the growth of the developing muscle. | The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development.
Zádor E, Vangheluwe P, Wuytack F. | 01/21/2010 |
| Targeted disruption of the gene encoding this protein in the sarco(endo)plasmic reticulum impairs diaphragm function and is lethal in neonatal mice. | Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.
Pan Y, Zvaritch E, Tupling AR, Rice WJ, de Leon S, Rudnicki M, McKerlie C, Banwell BL, MacLennan DH. | 01/21/2010 |
| Increased TR expression in the hypertrophied heart is associated with an improvement in contractile function and increased SERCA expression. | Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy.
Belke DD, Gloss B, Swanson EA, Dillmann WH. | 01/21/2010 |