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    Aqp8 aquaporin 8 [ Mus musculus (house mouse) ]

    Gene ID: 11833, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway.

    AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway.
    Hao Z, Huajun S, Zhen G, Yu X, Qian L, Ziling C, Zihao S, Qingqian X, Shujuan Z., Free PMC Article

    06/9/2023
    Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.

    Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.
    Okada N, Kawakita T, Ito M, Tsubota K., Free PMC Article

    10/9/2021
    AQP8 silencing impairs H2O2 entry into I.29micro+ B lymphoma cells. AQP8 can act as an efficient H2O2 channel also in cells of the B lineage.

    AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.
    Bertolotti M, Farinelli G, Galli M, Aiuti A, Sitia R.

    09/16/2017
    Rotavirus diarrhea is associated with the downregulation of AQP1, -4, and -8 expression.

    Involvement of aquaporins in a mouse model of rotavirus diarrhea.
    Cao M, Yang M, Ou Z, Li D, Geng L, Chen P, Chen H, Gong S., Free PMC Article

    05/16/2015
    AQP8 has a role in the formation of follicles and provided new insight into the molecular mechanisms of folliculogenesis.

    Occurrence of multi-oocyte follicles in aquaporin 8-deficient mice.
    Su W, Guan X, Zhang D, Sun M, Yang L, Yi F, Hao F, Feng X, Ma T., Free PMC Article

    09/6/2014
    Data indicate selective expression of aquaporins 3 and 8 in primitive erythroblasts and aquaporins 1 and 9 in adult definitive erythroblasts.

    Ontogeny of erythroid gene expression.
    Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, Stoeckert CJ, Palis J., Free PMC Article

    04/6/2013
    we conclude that AQP8 deficiency increases the number of mature follicles by reducing the apoptosis of granulosa cells, thus increasing the fertility of female mice[aquaporin 8]

    Increased female fertility in aquaporin 8-deficient mice.
    Su W, Qiao Y, Yi F, Guan X, Zhang D, Zhang S, Hao F, Xiao Y, Zhang H, Guo L, Yang L, Feng X, Ma T.

    07/25/2011
    Studies confirmed the involvement of AQP8 in alpha-amylase 2 regulation.

    Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of α-amylase in the colon.
    Magdeldin S, Li H, Yoshida Y, Satokata I, Maeda Y, Yokoyama M, Enany S, Zhang Y, Xu B, Fujinaka H, Yaoita E, Yamamoto T.

    05/28/2011
    The Hg(2+)-sensitive AQP8, which was localized in elongated spermatids and spermatozoa, is a likely candidate for a water channel responsible for physiological sperm volume regulation crucial to in vivo fertilization.

    Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.
    Yeung CH, Callies C, Rojek A, Nielsen S, Cooper TG.

    01/21/2010
    The results support the conclusion that AQP8 can facilitate NH(3) transport but provide evidence against physiologically significant AQP8-facilitated NH(3) transport in mice.

    Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport.
    Yang B, Zhao D, Solenov E, Verkman AS.

    01/21/2010
    analysis of AQP8 and AQP1 water channel expression in the mouse gall-bladder epithelium

    Expression and subcellular localization of the AQP8 and AQP1 water channels in the mouse gall-bladder epithelium.
    Calamita G, Ferri D, Bazzini C, Mazzone A, Bottà G, Liquori GE, Paulmichl M, Portincasa P, Meyer G, Svelto M.

    01/21/2010
    Phenotype of AQP8-null mice is not dramatically different from wild type mice.

    Phenotype analysis of aquaporin-8 null mice.
    Yang B, Song Y, Zhao D, Verkman AS.

    01/21/2010
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