| CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression. | CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression.
Cardoso MS, Gonçalves R, Oliveira L, Silvério D, Téllez É, Paul T, Sarrias MR, Carmo AM, Saraiva M. | 10/18/2024 |
| AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. | AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
Yasuda K, Shimodan S, Maehara N, Hirota A, Iijima R, Nishijima A, Mori H, Toyama R, Ito A, Yoshikawa Y, Arai S, Miyazaki T. | 03/25/2024 |
| Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD. | Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
Takimoto-Sato M, Suzuki M, Kimura H, Ge H, Matsumoto M, Makita H, Arai S, Miyazaki T, Nishimura M, Konno S., Free PMC Article | 08/22/2023 |
| [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models]. | [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
Wu X, Yang M, Guo W, Hu J, Dong K, Gao Z., Free PMC Article | 05/5/2023 |
| CD5L attenuates allergic airway inflammation by expanding CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2. | CD5L attenuates allergic airway inflammation by expanding CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2.
Weng D, Gao S, Shen H, Yao S, Huang Q, Zhang Y, Huang W, Wang Y, Zhang X, Yin Y, Xu W. | 10/15/2022 |
| AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. | AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.
Maehara N, Taniguchi K, Okuno A, Ando H, Hirota A, Li Z, Wang CT, Arai S, Miyazaki T. | 02/19/2022 |
| High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein. | High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.
Wang CT, Tezuka T, Takeda N, Araki K, Arai S, Miyazaki T., Free PMC Article | 01/8/2022 |
| IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development. | IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Hasegawa H, Mizoguchi I, Orii N, Inoue S, Katahira Y, Yoneto T, Xu M, Miyazaki T, Yoshimoto T., Free PMC Article | 12/11/2021 |
| The immunopathological role of apoptosis inhibitor of macrophage (AIM)/CD5L in sepsis. | Therapeutic Targeting of Apoptosis Inhibitor of Macrophage/CD5L in Sepsis.
Gao X, Yan X, Yin Y, Lin X, Zhang Q, Xia Y, Cao J. | 12/21/2019 |
| Our study identifies CD5L as a key pleiotropic inhibitor of chronic liver injury. | CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content.
Bárcena C, Aran G, Perea L, Sanjurjo L, Téllez É, Oncins A, Masnou H, Serra I, García-Gallo M, Kremer L, Sala M, Armengol C, Sancho-Bru P, Sarrias MR., Free PMC Article | 11/30/2019 |
| AIM appears to be involved in the prevention and repair process of a peritoneal dialysis-related fungal peritonitis. | Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice.
Tomita T, Arai S, Kitada K, Mizuno M, Suzuki Y, Sakata F, Nakano D, Hiramoto E, Takei Y, Maruyama S, Nishiyama A, Matsuo S, Miyazaki T, Ito Y., Free PMC Article | 02/9/2019 |
| AIM/CD5L-deficient mice demonstrated a smaller infarct size and less of an inflammatory response via inflammatory pathways after myocardial infarction; these data provide the first evidence that AIM/CD5L plays an important role in the inflammatory responses after myocardial injury | Deletion of Apoptosis Inhibitor of Macrophage (AIM)/CD5L Attenuates the Inflammatory Response and Infarct Size in Acute Myocardial Infarction.
Nishikido T, Oyama J, Shiraki A, Komoda H, Node K., Free PMC Article | 12/24/2016 |
| AIM enhances intratubular debris clearance and ameliorates acute kidney injury via interaction with KIM-1. | Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.
Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, Suzuki Y, Yahagi N, Nishiyama A, Gunaratnam L, Takano T, Miyazaki T. | 07/2/2016 |
| CD5L as a critical regulator that distinguishes Th17 functional states and identified T cell lipid metabolism as an integral component of the pathways regulating Th17 cell pathogenicity. | CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.
Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK., Free PMC Article | 04/9/2016 |
| plays a general homeostatic role by supporting innate immunity during pathogen aggression | The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression.
Martinez VG, Escoda-Ferran C, Tadeu Simões I, Arai S, Orta Mascaró M, Carreras E, Martínez-Florensa M, Yelamos J, Miyazaki T, Lozano F., Free PMC Article | 04/18/2015 |
| the assembled p40-CD5L heterodimer does not recapitulate the biological activity of IL-12. | Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.
Abdi K, Singh NJ, Spooner E, Kessler BM, Radaev S, Lantz L, Xiao TS, Matzinger P, Sun PD, Ploegh HL., Free PMC Article | 08/23/2014 |
| AIM contributes to key macrophage responses to M. tuberculosis | The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy.
Sanjurjo L, Amézaga N, Vilaplana C, Cáceres N, Marzo E, Valeri M, Cardona PJ, Sarrias MR., Free PMC Article | 08/23/2014 |
| AIM-IgM association plays a critical role in the obesity-associated autoimmune process. | Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.
Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T. | 11/16/2013 |
| SREBP-1a specifically activates the Api6 gene through a binding site in its proximal promoter, thus establishing the Api6 gene as a newly identified SREBP-1a target gene | Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a.
Im SS, Osborne TF., Free PMC Article | 02/23/2013 |
| N-glycosylation plays important roles in the secretion and lipolytic function of AIM | Modification of N-glycosylation modulates the secretion and lipolytic function of apoptosis inhibitor of macrophage (AIM).
Mori M, Kimura H, Iwamura Y, Arai S, Miyazaki T. | 12/29/2012 |
| AIM induces lipolysis in a manner distinct from that of hormone-dependent lipolysis, without activation or augmentation of lipases. | Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.
Iwamura Y, Mori M, Nakashima K, Mikami T, Murayama K, Arai S, Miyazaki T. | 09/1/2012 |
| Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. | Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.
Kurokawa J, Nagano H, Ohara O, Kubota N, Kadowaki T, Arai S, Miyazaki T., Free PMC Article | 10/8/2011 |
| AIM binds to cytosolic FAS protein at various regions responsible for elongation of fatty acids, release of synthesized palmitate, and stabilization of FAS dimerization. | Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
Kurokawa J, Arai S, Nakashima K, Nagano H, Nishijima A, Miyata K, Ose R, Mori M, Kubota N, Kadowaki T, Oike Y, Koga H, Febbraio M, Iwanaga T, Miyazaki T. | 09/13/2010 |
| Bacterial lipoteichoic acid might affect the pathogenesis of epithelial inflammation followed by fibrosis in systemic multifocal epithelial inflammations in chronic colitis-harboring TCR alpha(-/-) x AIM(-/-) mice | Systemic multifocal epithelial inflammations associated with PBC-like bile duct damage in chronic colitis harboring TCR alpha -/- x AIM -/- mice: does lipoteichoic acid affect the pathogenesis of epithelial inflammation followed by fibrosis?
Haruta I, Hashimoto E, Kobayashi M, Shiratori K. | 01/21/2010 |
| The protein inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice. | AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice.
Kuwata K, Watanabe H, Jiang SY, Yamamoto T, Tomiyama-Miyaji C, Abo T, Miyazaki T, Naito M., Free PMC Article | 01/21/2010 |