| Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury. | Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
Wang S, Zhao M, Zhang X, Su M, Tian Y, Qiu W. | 06/22/2023 |
| M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination. | M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
Li Y, Wu Y, Khan I, Zhou J, Lu Y, Ye J, Liu J, Xie X, Hu C, Jiang H, Fan S, Zhang H, Zhang Y, Jiang X, Xu B, Ma H, Shi Q., Free PMC Article | 02/14/2023 |
| Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. | Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.
Biswas DD, Martin RK, Brown LN, Mockenhaupt K, Gupta AS, Surace MJ, Tharakan A, Yester JW, Bhardwaj R, Conrad DH, Kordula T., Free PMC Article | 07/2/2022 |
| A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma. | A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.
Wu Q, Berglund AE, MacAulay RJ, Etame AB., Free PMC Article | 02/5/2022 |
| Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils. | Targeting cIAPs attenuates CCl(4)-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
Wu Y, Lu S, Huang X, Liu Y, Huang K, Liu Z, Xu W, Zhu W, Hou J, Liu H, Zhang X. | 01/15/2022 |
| IAP inhibition or loss of both cIAP2 and XIAP resulted in a strong blockage in autophagic flux and mitophagy, suggesting that XIAP deficiency may also drive Crohn's Disease due to defects in autophagy. | Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.
Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Häcker G, Gentle IE., Free PMC Article | 11/9/2019 |
| Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation. | Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
Suzuki S, Suzuki T, Mimuro H, Mizushima T, Sasakawa C., Free PMC Article | 01/5/2019 |
| These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations. | XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE. | 04/7/2018 |
| These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1. | DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.
Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Michaud O, Solary E, Dubrez L., Free PMC Article | 02/24/2018 |
| Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha. | IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Shekhar TM, Miles MA, Gupte A, Taylor S, Tascone B, Walkley CR, Hawkins CJ., Free PMC Article | 12/23/2017 |
| downregulation of cIAPs in PSC cholangiocytes may contribute to the development of the disease. Our results also indicate that inhibition of TRAIL signaling pathways may be beneficial in the treatment of PSC | Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice.
Guicciardi ME, Krishnan A, Bronk SF, Hirsova P, Griffith TS, Gores GJ., Free PMC Article | 10/28/2017 |
| We show that BIRC3 has a unique role in facilitating glioma progression from low- to high-grade | Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma.
Gressot LV, Doucette T, Yang Y, Fuller GN, Manyam G, Rao A, Latha K, Rao G., Free PMC Article | 09/23/2017 |
| These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2, K48-linked ubiquitination, and degradation of TRAF3. | Endotoxin Tolerance Inhibits Degradation of Tumor Necrosis Factor Receptor-Associated Factor 3 by Suppressing Pellino 1 Expression and the K48 Ubiquitin Ligase Activity of Cellular Inhibitor of Apoptosis Protein 2.
Li P, Liu H, Zhang Y, Liao R, He K, Ruan X, Gong J. | 05/27/2017 |
| Birc3-deficient mice are resistant to azoxymethane-sodium dodecyl sulfate-induced colitis-associated colorectal cancer. | A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.
Dagenais M, Dupaul-Chicoine J, Champagne C, Skeldon A, Morizot A, Saleh M. | 10/1/2016 |
| c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. | c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.
Giardino Torchia ML, Munitic I, Castro E, Herz J, McGavern DB, Ashwell JD., Free PMC Article | 11/28/2015 |
| Induction of cIAP2 expression upon microglia activation prevents the conversion of caspase-3 p19 subunit to p17 subunit. | Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia.
Kavanagh E, Rodhe J, Burguillos MA, Venero JL, Joseph B., Free PMC Article | 09/12/2015 |
| we show that cIAP1 regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependentpathway | cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.
Marivin A, Berthelet J, Cartier J, Paul C, Gemble S, Morizot A, Boireau W, Saleh M, Bertoglio J, Solary E, Dubrez L. | 01/24/2015 |
| cIAP2 (Birc3)-dependent antagonism of RIPK3-mediated programmed necrosis critically protects the host from influenza infection through maintenance of pulmonary tissue homeostasis. | Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Rodrigue-Gervais IG, Labbé K, Dagenais M, Dupaul-Chicoine J, Champagne C, Morizot A, Skeldon A, Brincks EL, Vidal SM, Griffith TS, Saleh M. | 06/14/2014 |
| cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-kappaB. | cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-κB.
Philip L, Shivakumar K. | 12/14/2013 |
| these results show that the loss of cIAP1 protects skeletal muscle from the degenerative pathology resulting from systemic loss of dystrophin. | Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.
Enwere EK, Boudreault L, Holbrook J, Timusk K, Earl N, LaCasse E, Renaud JM, Korneluk RG., Free PMC Article | 07/27/2013 |
| a molecular mechanism for cIAP1's regulation in the NOD2 signaling pathway | A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling.
Tigno-Aranjuez JT, Bai X, Abbott DW., Free PMC Article | 04/27/2013 |
| TWEAK, cIAP1, and noncanonical NF-kappaB signaling has roles in the regulation of myoblast fusion | TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.
Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG. | 03/23/2013 |
| NFATc1 mRNA expression is negatively regulated by inhibitor of apoptosis protein 1 during osteoclastogenesis. | cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression.
Yamaguchi N, Yokota M, Taguchi Y, Gohda J, Inoue J. | 03/23/2013 |
| cIAP2 expression protects macrophages from Rip1-dependent necroptotic cell death and facilitates pathogen control. | cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.
McComb S, Cheung HH, Korneluk RG, Wang S, Krishnan L, Sad S., Free PMC Article | 03/9/2013 |
| found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11 | An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Kenneth NS, Younger JM, Hughes ED, Marcotte D, Barker PA, Saunders TL, Duckett CS., Free PMC Article | 05/19/2012 |