| Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy. | Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy.
Diao J, Fan H, Zhang J, Fu X, Liao R, Zhao P, Huang W, Huang S, Liao H, Yu J, Pan D, Wang M, Xiao W, Wen X. | 02/13/2024 |
| APE1 promotes embryonic stem cell proliferation and teratoma formation by regulating GDNF/GFRalpha1 axis. | APE1 promotes embryonic stem cell proliferation and teratoma formation by regulating GDNF/GFRα1 axis.
Liu L, Wu Q, Wang Z, Niu B, Jiao Y, An H. | 08/30/2023 |
| APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells. | APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells.
Zaunz S, De Smedt J, Lauwereins L, Cleuren L, Laffeber C, Bajaj M, Lebbink JHG, Marteijn JA, De Keersmaecker K, Verfaillie C., Free PMC Article | 08/2/2023 |
| APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. | APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.
Schrader CE, Williams T, Pechhold K, Linehan EK, Tsuchimoto D, Nakabeppu Y., Free PMC Article | 05/17/2023 |
| APE1/Ref-1 Inhibits Adipogenic Transcription Factors during Adipocyte Differentiation in 3T3-L1 Cells. | APE1/Ref-1 Inhibits Adipogenic Transcription Factors during Adipocyte Differentiation in 3T3-L1 Cells.
Lee EO, Joo HK, Lee YR, Kim S, Lee KH, Lee SD, Jeon BH., Free PMC Article | 03/1/2023 |
| A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells. | A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells.
Rios-Covian D, Butcher LD, Ablack AL, den Hartog G, Matsubara MT, Ly H, Oates AW, Xu G, Fisch KM, Ahrens ET, Toden S, Brown CC, Kim K, Le D, Eckmann L, Dhar B, Izumi T, Ernst PB, Crowe SE., Free PMC Article | 01/28/2023 |
| A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions. | A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions.
Desai RV, Chen X, Martin B, Chaturvedi S, Hwang DW, Li W, Yu C, Ding S, Thomson M, Singer RH, Coleman RA, Hansen MMK, Weinberger LS., Free PMC Article | 08/28/2021 |
| APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling. | APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling.
Liu TC, Lin CT, Chang KC, Guo KW, Wang S, Chu JW, Hsiao YY., Free PMC Article | 02/6/2021 |
| Ref-1 displays strong anti-inflammatory activity in lipopolysaccharide-induced septic mice. | The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice.
Joo HK, Lee YR, Lee EO, Park MS, Choi S, Kim CS, Park JB, Jeon BH. | 06/20/2020 |
| Ape1 knockout mice appeared hypothermic with persistent shivering associated with the loss of thermoregulatory serotonergic neurons. | Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.
Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ., Free PMC Article | 03/23/2019 |
| We suggest that serum APE1/Ref-1 can be used to assess for myocardial injury in viral myocarditis without endomyocardial biopsy | Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis.
Jin SA, Lim BK, Seo HJ, Kim SK, Ahn KT, Jeon BH, Jeong JO., Free PMC Article | 07/28/2018 |
| AOM, a colorectal cancer carcinogen, generates damage to the mitochondrial genome, and the BER enzyme APE1 is required to maintain its integrity. | Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer.
Ballista-Hernández J, Martínez-Ferrer M, Vélez R, Climent C, Sánchez-Vázquez MM, Torres C, Rodríguez-Muñoz A, Ayala-Peña S, Torres-Ramos CA., Free PMC Article | 04/7/2018 |
| findings provide evidence that endogenous APE1 protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury | APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.
Stetler RA, Gao Y, Leak RK, Weng Z, Shi Y, Zhang L, Pu H, Zhang F, Hu X, Hassan S, Ferguson C, Homanics GE, Cao G, Bennett MV, Chen J., Free PMC Article | 07/22/2017 |
| Suppression of Ape1/Ref-1 redox function leads to an increased cell surface retention of IL-12 and enhances Th1 responses. | Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, Asao H., Free PMC Article | 06/3/2017 |
| Is closely associated with upregulation of the Ref1/Nrf2 signalling pathway. | Acute exercise stress promotes Ref1/Nrf2 signalling and increases mitochondrial antioxidant activity in skeletal muscle.
Wang P, Li CG, Qi Z, Cui D, Ding S. | 01/14/2017 |
| Results show the stimulatory effect of PARP-1 on APE1-dependent base excision repair (BER). PARP-1 and APE1 appear to have a functional interaction in BER since PARP-1 can stimulate the strand incision activity of APE1. | Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair.
Prasad R, Dyrkheeva N, Williams J, Wilson SH., Free PMC Article | 04/30/2016 |
| increases in APEX1 level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells | Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice.
Sanchez JR, Reddick TL, Perez M, Centonze VE, Mitra S, Izumi T, McMahan CA, Walter CA., Free PMC Article | 11/28/2015 |
| Endothelial cell tumor proliferation was found to be dependent on Apex-1 expression. | Endothelial cell tumor growth is Ape/ref-1 dependent.
Biswas A, Khanna S, Roy S, Pan X, Sen CK, Gordillo GM., Free PMC Article | 11/21/2015 |
| Expression of OGG1 and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity. | Aroclor 1254-induced genotoxicity in male gonads through oxidatively damaged DNA and inhibition of DNA repair gene expression.
Attia SM, Ahmad SF, Okash RM, Bakheet SA. | 05/16/2015 |
| Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR). | APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.
Xu J, Husain A, Hu W, Honjo T, Kobayashi M., Free PMC Article | 05/2/2015 |
| These results suggest that mitochondrial APE1/Ref-1 is contributed to the protective role to protein kinase C-induced mitochondrial dysfunction in endothelial cells. | Mitochondrial APE1/Ref-1 suppressed protein kinase C-induced mitochondrial dysfunction in mouse endothelial cells.
Joo HK, Lee YR, Park MS, Choi S, Park K, Lee SK, Kim CS, Park JB, Jeon BH. | 04/4/2015 |
| Spinal motor neurones down-regulate APE1 upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions. | Down-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) in spinal motor neurones under oxidative stress.
Chu TH, Guo A, Wu W. | 01/31/2015 |
| The reductive activation of endothelial SIRT1 by APE1/Ref-1 mediates the effect of APE1/Ref-1 on eNOS acetylation, promoting endothelium-derived NO and endothelium-dependent vasorelaxation. | Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.
Jung SB, Kim CS, Kim YR, Naqvi A, Yamamori T, Kumar S, Kumar A, Irani K., Free PMC Article | 01/17/2015 |
| Together, these data show that the expression of APE1 is crucial for efficient transcription of ribosomal genes. | Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.
Poletto M, Lirussi L, Wilson DM 3rd, Tell G., Free PMC Article | 01/17/2015 |
| Voluntary running wheel exercise significantly increases levels of BDNF, activates CREB, and upregulates APE1 in the cerebral cortex and hippocampus of mice. | BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.
Yang JL, Lin YT, Chuang PC, Bohr VA, Mattson MP., Free PMC Article | 11/8/2014 |