| Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis. | Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.
Gaur P, Rajendran Y, Srivastava B, Markandey M, Fishbain-Yoskovitz V, Mohapatra G, Suhail A, Chaudhary S, Tyagi S, Yadav SC, Pandey AK, Merbl Y, Bajaj A, Ahuja V, Srikanth C., Free PMC Article | 04/24/2024 |
| CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome. | CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.
Lv X, Zheng L, Zhang T, Wang W, Chen Y, Li J, Cai Z, Guo X, Song L. | 04/24/2024 |
| Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement. | Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.
Berry KN, Brett TJ., Free PMC Article | 02/13/2021 |
| SDR16C5 and SDR16C6 enzymes are not critical for survival but are responsible for most of the retinol dehydrogenase activity in skin, essential for the regulation of the hair-follicle cycle, and required for the maintenance of both sebaceous and meibomian glands | Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.
Nyström EEL, Arike L, Ehrencrona E, Hansson GC, Johansson MEV., Free PMC Article | 06/13/2020 |
| Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation. | Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity.
Nyström EEL, Birchenough GMH, van der Post S, Arike L, Gruber AD, Hansson GC, Johansson MEV., Free PMC Article | 11/10/2018 |
| CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway | CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway.
Li X, Hu W, Zhou J, Huang Y, Peng J, Yuan Y, Yu J, Zheng S., Free PMC Article | 06/23/2018 |
| Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A at the cell surface by preventing its internalization. | Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).
Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ., Free PMC Article | 06/10/2017 |
| Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A) co-localize and physically interact and that CLCA1 increases the level of TMEM16A protein at the cell surface. | Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.
Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ., Free PMC Article | 01/23/2016 |
| inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation | Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1).
Musrap N, Tuccitto A, Karagiannis GS, Saraon P, Batruch I, Diamandis EP., Free PMC Article | 10/3/2015 |
| Results confirmed that the low expression of CLCA1 in CRC was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival. | Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer.
Yang B, Cao L, Liu J, Xu Y, Milne G, Chan W, Heys SD, McCaig CD, Pu J., Free PMC Article | 07/25/2015 |
| These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation. | Secreted hCLCA1 is a signaling molecule that activates airway macrophages.
Ching JC, Lobanova L, Loewen ME., Free PMC Article | 04/4/2015 |
| CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells. | The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.
Yang B, Cao L, Liu B, McCaig CD, Pu J., Free PMC Article | 10/26/2013 |
| CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD patients, and may contribute to the development and pathogenesis of COPD by inducing mucus production. | Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients.
Iwashita H, Fujimoto K, Morita S, Nakanishi A, Kubo K., Free PMC Article | 05/4/2013 |
| These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface. | Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ., Free PMC Article | 02/16/2013 |
| Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC. | [Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].
Wu W, Zhen H, Cui Y, Chu H, Wang L. | 07/23/2011 |
| in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis patients but not mucus expression | Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.
Hauber HP, Lavigne F, Hung HL, Levitt RC, Hamid Q. | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe CFTR genotype (P = 0.009) and in p.F508del homozygotes (P = 0.002). | Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.
van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH, van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH. | 08/23/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| genetic polymorphism is associated with childhood asthma | The CLCA gene family: putative therapeutic target for respiratory diseases.
Winpenny JP, Marsey LL, Sexton DW. | 01/21/2010 |
| hClCa1 does not form Ca(2+)-dependent Cl- channels per se. hClCa1 elevates the single channel conductance of endogenous Ca(2+)-dependent Cl- channels by lowering the energy barriers for ion translocation through the pore. | Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents.
Hamann M, Gibson A, Davies N, Jowett A, Walhin JP, Partington L, Affleck K, Trezise D, Main M., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.
van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH, van der Doef HP, Slieker MG, Staab D, Alizadeh BZ, Seia M, Colombo C, van der Ent CK, Nickel R, Witt H, Houwen RH. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. Association of the hCLCA1 gene with childhood and adult asthma.
Kamada F, Suzuki Y, Shao C, Tamari M, Hasegawa K, Hirota T, Shimizu M, Takahashi N, Mao XQ, Doi S, Fujiwara H, Miyatake A, Fujita K, Chiba Y, Aoki Y, Kure S, Tamura G, Shirakawa T, Matsubara Y. | 03/13/2008 |
| These results suggest that the up-regulated gene expression of CaCC1 exists, which is complicated with mucus hyper-secretion in Chinese asthmatic airway. | Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway.
Wang K, Wen FQ, Feng YL, Ou XM, Xu D, Yang J, Deng ZP. | 01/21/2010 |
| CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis | The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Ritzka M, Stanke F, Jansen S, Gruber AD, Pusch L, Woelfl S, Veeze HJ, Halley DJ, Tümmler B. | 01/21/2010 |
| CACC play a direct role in mucus production by goblet cells and may thus contribute to the pathogenesis of asthma. | Oxidant stress stimulates Ca2+-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells.
Jeulin C, Guadagnini R, Marano F. | 01/21/2010 |