| Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training. | Twist2-expressing cells reside in human skeletal muscle and are responsive to aging and resistance exercise training.
Gaulton N, Wakelin G, Young LV, Wotherspoon S, Kamal M, Parise G, Nederveen JP, Holwerda A, Verdijk LB, van Loon LJC, Snijders T, Johnston AP. | 11/19/2022 |
| Single Nucleotide Polymorphism of TWIST2 May Be a Modifier for the Association between High-Density Lipoprotein Cholesterol and Blood Lead (Pb) Level. | Single Nucleotide Polymorphism of TWIST2 May Be a Modifier for the Association between High-Density Lipoprotein Cholesterol and Blood Lead (Pb) Level.
Yang CC, Dai CY, Luo KH, Lee KW, Wu CH, Hung CH, Chuang HY, Kuo CH., Free PMC Article | 05/21/2022 |
| MIR205 host gene (MIR205HG) drives osteosarcoma metastasis via regulating the microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis. | MIR205 host gene (MIR205HG) drives osteosarcoma metastasis via regulating the microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis.
Wang X, Yu X, Long X, Pu Q., Free PMC Article | 12/4/2021 |
| TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis. | TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis.
Zhang Y, Ge X, Li Y, Zhang B, Wang P, Hao M, Gao P, Zhao Y, Sun T, Lu S, Ma W., Free PMC Article | 11/27/2021 |
| Inhibition of p53/p21 by TWIST alleviates TNF-alpha induced nucleus pulposus cell senescence in vitro. | Inhibition of p53/p21 by TWIST alleviates TNF-α induced nucleus pulposus cell senescence in vitro.
Qiu HB, Bian WG, Zhang LJ, Mei N, Wu Y, Wei YQ, Han XZ. | 07/3/2021 |
| LINC01235-TWIST2 feedback loop facilitates epithelial-mesenchymal transition in gastric cancer by inhibiting THBS2. | LINC01235-TWIST2 feedback loop facilitates epithelial-mesenchymal transition in gastric cancer by inhibiting THBS2.
Tan YE, Xing Y, Ran BL, Zhang C, Pan SW, An W, Chen QC, Xu HM., Free PMC Article | 05/22/2021 |
| Expression Profiling Identifies TWIST2 Target Genes in Setleis Syndrome Patient Fibroblast and Lymphoblast Cells. | Expression Profiling Identifies TWIST2 Target Genes in Setleis Syndrome Patient Fibroblast and Lymphoblast Cells.
Crespo NE, Torres-Bracero A, Renta JY, Desnick RJ, Cadilla CL., Free PMC Article | 05/1/2021 |
| Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. | Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes.
Lehman HL, Kidacki M, Stairs DB., Free PMC Article | 03/28/2021 |
| Periostin induces epithelialtomesenchymal transition via the integrin alpha5beta1/TWIST2 axis in cholangiocarcinoma. | Periostin induces epithelial‑to‑mesenchymal transition via the integrin α5β1/TWIST‑2 axis in cholangiocarcinoma.
Sonongbua J, Siritungyong S, Thongchot S, Kamolhan T, Utispan K, Thuwajit P, Pongpaibul A, Wongkham S, Thuwajit C., Free PMC Article | 09/19/2020 |
| CASC9 enhances cervical cancer progression by promoting metastasis through the meditation of miR-215/TWIST2 signaling associated with TGF-beta expression | Long non-coding RNA CASC9 enhances breast cancer progression by promoting metastasis through the meditation of miR-215/TWIST2 signaling associated with TGF-β expression.
Zhang J, Wang Q, Quan Z. | 07/11/2020 |
| results suggest that twist family basic helix-loop-helix transcription factor 2 (TWIST2) could function as a tumor suppressor involved in the pathogenesis of prostate cancer by influencing the expression of target genes | TWIST2: A new candidate tumor suppressor in prostate cancer.
Zhao C, Zhang W, Zhu X, Xu Y, Yang K, Wei D, Liang S, Zhao F, Zhang Y, Chen X, Sun L, Yuan H, Shi X, Wang X, Liu M, Yang F, Wang J, Yang Z., Free PMC Article | 02/22/2020 |
| Twist1/2 can bind to the MMP2 promoter and promote its transcription, enhancing the invasive potential of colorectal cancer cells. | Twist1/2 activates MMP2 expression via binding to its promoter in colorectal cancer.
Lu K, Dong JL, Fan WJ. | 12/7/2019 |
| findings indicate that during differentiation, Twist2 globally shifts MyoD activity from myogenic loci to EMT and tumor growth loci through competition and epigenetic modifications at promoters and enhancers, highlighting the central role of TWIST2 in rhabdomyosarcoma pathogenesis | Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding.
Li S, Chen K, Zhang Y, Barnes SD, Jaichander P, Zheng Y, Hassan M, Malladi VS, Skapek SX, Xu L, Bassel-Duby R, Olson EN, Liu N., Free PMC Article | 09/7/2019 |
| Together, these data suggest that the S18-2 protein induces epithelial to mesenchymal cell transition through the TWIST2/E-cadherin signalling and, consequently, CXCR4-mediated migration of prostate cancer cells. | The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells.
Mushtaq M, Jensen L, Davidsson S, Grygoruk OV, Andrén O, Kashuba V, Kashuba E., Free PMC Article | 12/22/2018 |
| epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients | EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells.
Han M, Xu W. | 07/29/2017 |
| Findings indicated that HIF-2alpha promotes epithelial-mesenchymal transition in pancreatic cancer by regulating Twist2 binding to the promoter of E-cadherin. | HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer.
Yang J, Zhang X, Zhang Y, Zhu D, Zhang L, Li Y, Zhu Y, Li D, Zhou J., Free PMC Article | 10/22/2016 |
| A homozygous missense mutation in the TWIST2 gene was described in 3 siblings affected by Setleis syndrome. An alteration of bHLH domain, and loss of transcription factor's function was predicted due to protein substitution. | Setleis syndrome: clinical, molecular and structural studies of the first TWIST2 missense mutation.
Rosti RO, Uyguner ZO, Nazarenko I, Bekerecioglu M, Cadilla CL, Ozgur H, Lee BH, Aggarwal AK, Pehlivan S, Desnick RJ., Free PMC Article | 07/30/2016 |
| TWIST2 regulates epithelial-mesenchymal transition by depriving the epithelial cell phenotype of E-cadherin and endowing the mesenchymal cell phenotype with Vimentin, which may be involved in the progression and prognosis of ovarian cancer. | Role of TWIST2, E-cadherin and Vimentin in epithelial ovarian carcinogenesis and prognosis and their interaction in cancer progression.
Li X, Yang J, Wang X, Li X, Liang J, Xing H. | 05/7/2016 |
| MACC1 promotes vasculogenic mimicry in gastric cancer by regulating the HGF/c-Met-TWIST1/2 signaling pathway. | Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2.
Wang L, Lin L, Chen X, Sun L, Liao Y, Huang N, Liao W., Free PMC Article | 03/5/2016 |
| In patients with no duplication/triplication of the 1p36.22p36.21 region and no mutations in TWIST2, there are mutation(s) in one of the 30 genes in this region or mutations in other as yet unidentified genes at different locations | Chromosome 1p36.22p36.21 duplications/triplication causes Setleis syndrome (focal facial dermal dysplasia type III).
Weaver DD, Norby AR, Rosenfeld JA, Proud VK, Spangler BE, Ming JE, Chisholm E, Zackai EH, Lee BH, Edelmann L, Desnick RJ. | 01/16/2016 |
| Data suggest that TWIST1 and to a lesser degree TWIST2 expressed within the tumor stroma could contribute to the epithelial-mesenchymal transition (EMT)-like tumor budding phenotype in colorectal cancers. | TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer.
Galván JA, Helbling M, Koelzer VH, Tschan MP, Berger MD, Hädrich M, Schnüriger B, Karamitopoulou E, Dawson H, Inderbitzin D, Lugli A, Zlobec I., Free PMC Article | 11/28/2015 |
| A substituted lysine at TWIST2 residue 75 results in Ablepharon Macrostomia Syndrome, whereas a glutamine or alanine yields Barber-Say Syndrome. | Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.
Marchegiani S, Davis T, Tessadori F, van Haaften G, Brancati F, Hoischen A, Huang H, Valkanas E, Pusey B, Schanze D, Venselaar H, Vulto-van Silfhout AT, Wolfe LA, Tifft CJ, Zerfas PM, Zambruno G, Kariminejad A, Sabbagh-Kermani F, Lee J, Tsokos MG, Lee CC, Ferraz V, da Silva EM, Stevens CA, Roche N, Bartsch O, Farndon P, Bermejo-Sanchez E, Brooks BP, Maduro V, Dallapiccola B, Ramos FJ, Chung HY, Le Caignec C, Martins F, Jacyk WK, Mazzanti L, Brunner HG, Bakkers J, Lin S, Malicdan MC, Boerkoel CF, Gahl WA, de Vries BB, van Haelst MM, Zenker M, Markello TC., Free PMC Article | 09/26/2015 |
| After chronic NOD2 stimulation, Twist1 and Twist2 coordinate the regulation of both transcriptional activators and repressors, thereby mediating optimal cytokine down-regulation. | Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators.
Zheng S, Hedl M, Abraham C., Free PMC Article | 09/5/2015 |
| Results show that Twist2 expression was gradually increased during the progression from normal cervical squamous epithelium to cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma. | The indicative function of Twist2 and E-cadherin in HPV oncogene-induced epithelial-mesenchymal transition of cervical cancer cells.
Liu Y, Qian W, Zhang J, Dong Y, Shi C, Liu Z, Wu S. | 08/22/2015 |
| Data have identified a novel TWIST2-p21 axis that regulates the cell cycle of both normal and leukemic hematopoietic cells, which implicates TWIST2 as a novel tumor suppressor in human acute myeloid leukemia. | Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia.
Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D, Zhao Y. | 08/8/2015 |