| Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. | Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.
Wong WLE, Arathimos R, Lewis CM, Young AH, Dawe GS., Free PMC Article | 11/28/2023 |
| The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review. | The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.
Wong WLE, Dawe GS, Young AH. | 03/5/2022 |
| Serum level of relaxin-3 hormone is an important mediator in the pathophysiological process of normal puberty being significantly decreased in males with delayed puberty. | Serum relaxin-3 hormone relationship to male delayed puberty.
Hanafy S, Sabry JH, Akl EM, Elethy RA, Mostafa T. | 09/22/2018 |
| Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. | Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. | 01/27/2018 |
| the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively. | Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.
Hu MJ, Shao XX, Wang JH, Wei D, Liu YL, Xu ZG, Guo ZY. | 12/16/2017 |
| In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. | Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gonçalves F, Mendonça L, Fontes-Carvalho R, Lourenço P, Almeida P, Leite-Moreira A, Bettencourt P. | 11/11/2017 |
| the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 | A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Liu Y, Zhang L, Shao XX, Hu MJ, Liu YL, Xu ZG, Guo ZY. | 05/13/2017 |
| Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. | The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.
Ang SY, Hutchinson DS, Evans BA, Hossain MA, Patil N, Bathgate RA, Kocan M, Summers RJ. | 02/25/2017 |
| Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. | Physical fitness, serum relaxin and duration of gestation.
Thorell E, Goldsmith L, Weiss G, Kristiansson P., Free PMC Article | 03/26/2016 |
| Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion. | [Relaxin-3 and relaxin family peptide receptors--from structure to functions of a newly discovered mammalian brain system].
Kania A, Lewandowski MH, Błasiak A. | 03/28/2015 |
| we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor | Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).
Kocan M, Sarwar M, Hossain MA, Wade JD, Summers RJ., Free PMC Article | 01/3/2015 |
| Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. | The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.
Zhang WJ, Wang XY, Guo YQ, Luo X, Gao XJ, Shao XX, Liu YL, Xu ZG, Guo ZY. | 01/3/2015 |
| Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. | The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.
Wang XY, Guo YQ, Zhang WJ, Shao XX, Liu YL, Xu ZG, Guo ZY. | 09/6/2014 |
| Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes. | The plasma levels of relaxin-2 and relaxin-3 in patients with diabetes.
Zhang X, Zhu M, Zhao M, Chen W, Fu Y, Liu Y, Liu W, Zhang B, Yin X, Bai B. | 05/31/2014 |
| metabolic syndrome is associated with increased serum relaxin-3 levels in women | Relaxin-3 is associated with metabolic syndrome and its component traits in women.
Ghattas MH, Mehanna ET, Mesbah NM, Abo-Elmatty DM. | 06/8/2013 |
| [review] Relaxin-3 (RXF3P) is expressed within GABA neurons of the brainstem including an area known as the nucleus incertus; ascending relaxin-3 projections innervate a broad range of RXFP3-rich forebrain areas. | Relaxin-3 systems in the brain--the first 10 years.
Smith CM, Ryan PJ, Hosken IT, Ma S, Gundlach AL. | 08/18/2012 |
| H3 relaxin exerts antifibrotic actions via RXFP1 receptor | H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
Hossain MA, Man BC, Zhao C, Xu Q, Du XJ, Wade JD, Samuel CS. | 04/9/2011 |
| Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. | Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues.
Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA. | 03/1/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth.
Vogel I, Hollegaard MV, Hougaard DM, Thorsen P, Grove J. | 01/20/2010 |
| Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. | The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.
Hossain MA, Bathgate RA, Rosengren KJ, Shabanpoor F, Zhang S, Lin F, Tregear GW, Wade JD. | 01/21/2010 |
| analysis of truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides and their binding and cAMP activities on RXFP1, RXFP2, and RXFP3 | The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.
Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA. | 01/21/2010 |
| RLN3 chimeric peptide is a potential tool to study in vivo function of GPCR135. | Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW. | 01/21/2010 |
| GPCR135 is the receptor for relaxin-3 | Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.
Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jörnvall H, Sillard R, Lovenberg TW. | 01/21/2010 |
| relaxin-3/INSL7 is a ligand for GPCR142 | Identification of relaxin-3/INSL7 as a ligand for GPCR142.
Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW. | 01/21/2010 |
| functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins | Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.
Van der Westhuizen ET, Sexton PM, Bathgate RA, Summers RJ. | 01/21/2010 |