| siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells. | siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells.
Liu Q, Liu C, Lei B. | 06/27/2024 |
| TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development. | TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
Sun HG, Jiang Q, Fan WJ, Shen XY, Wang ZW, Wang X., Free PMC Article | 12/20/2023 |
| Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual roles. | Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles.
Shan S, Su M, Li Y, Wang Z, Liu D, Zhou Y, Fu X, Yang S, Zhang J, Qiu J, Liu H, Zeng G, Chen P, Wang X, DiSanto ME, Guo Y, Zhang X., Free PMC Article | 11/1/2023 |
| Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway. | Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
Zhou W, Yuan X, Li J, Wang W, Ye S. | 07/31/2023 |
| Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats. | Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats.
Li L, Wang Q, Sun X, Li Z, Liu S, Zhang X, Zhou J, Zhang R, Liu K, Wang P, Niu J, Wen Y, Zhang L. | 03/22/2023 |
| Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA. | Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA.
Di Donato M, Bilancio A, Auricchio F, Castoria G, Migliaccio A., Free PMC Article | 02/15/2023 |
| Effects of RhoA on depression-like behavior in prenatally stressed offspring rats. | Effects of RhoA on depression-like behavior in prenatally stressed offspring rats.
Zhou J, Ma Y, Chen J, Yao D, Feng C, Dong Y, Ren Y, Ma H, Wang Z, Li G, Li H, Zhu Z. | 07/30/2022 |
| Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway. | Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway.
Ning L, Gao L, Zhang F, Li X, Wang T., Free PMC Article | 01/22/2022 |
| Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK. | Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
Mao Y, Finnemann SC., Free PMC Article | 12/4/2021 |
| Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current. | Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current.
Abramochkin DV, Filatova TS, Pustovit KB, Dzhumaniiazova I, Karpushev AV. | 08/7/2021 |
| Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity. | Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity.
Feng Y, Duan C, Luo Z, Xiao W, Tian F., Free PMC Article | 05/15/2021 |
| TGF-beta1 promotes pulmonary arterial hypertension in rats via activating RhoA/ROCK signaling pathway. | TGF-β1 promotes pulmonary arterial hypertension in rats via activating RhoA/ROCK signaling pathway.
Zhang Y, Yuan RX, Bao D. | 04/3/2021 |
| RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. | RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.
Tan D, Zhang H, Deng J, Liu J, Wen J, Li L, Wang X, Pan M, Hu X, Guo J., Free PMC Article | 01/9/2021 |
| Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling. | Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling.
Fan S, Xiong Q, Zhang X, Zhang L, Shi Y. | 01/9/2021 |
| 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway. | 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway.
Zhang F, Chen S, Wen JY, Chen ZW. | 12/19/2020 |
| Rho GDP dissociation inhibitor alpha silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling | Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
Wei Z, Xu H, Zhang Y, Yi X, Yang X, Chen Y, Mao N, Li S, Xu D, Li S, Zhang H, Li D, Zhang G, Zhang B, Jin F, Gao X, Cai W, Zhang L, Wang R, Yang F. | 07/4/2020 |
| These findings suggest that TGFbeta1 regulates Rap1, resulting in the suppression of RhoA, activation of and formation of Factin during the migration of hepatic stellate cells. | Rap1 regulates hepatic stellate cell migration through the modulation of RhoA activity in response to TGF‑β1.
Moon MY, Kim HJ, Kim MJ, Uhm S, Park JW, Suk KT, Park JB, Kim DJ, Kim SE., Free PMC Article | 12/28/2019 |
| RhoA activation can regulate Drp1 to induce mitochondrial fission. | RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes.
Brand CS, Tan VP, Brown JH, Miyamoto S., Free PMC Article | 09/21/2019 |
| Naturally occurring cytokinesis failure in primary cardiomyocytes is due to an aberrant mitotic microtubule apparatus and mislocalization of RhoA and IQGAP3 resulting in inefficient anchorage of the actomyosin ring to the plasma cell membrane. | Cardiomyocyte binucleation is associated with aberrant mitotic microtubule distribution, mislocalization of RhoA and IQGAP3, as well as defective actomyosin ring anchorage and cleavage furrow ingression.
Leone M, Musa G, Engel FB. | 08/17/2019 |
| The present study provides the first evidence that RhoA activity is downregulated by PKCalpha in depolarized and PDBu treated freshly isolated VSMCs and arteries, with an important physiological role on arterial contractility. | PKCα-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCα and ROCK Inhibition.
González-Montelongo MDC, Porras-González C, González-Montelongo R, Revilla-González G, Pastor MD, Castellano A, Ureña J. | 03/9/2019 |
| In addition to enhanced RhoA-mediated Ca(2+) sensitization following CH, RhoA can also activate a Ca(2+) signal by facilitating ASIC1a plasma membrane localization and Ca(2+) influx in pulmonary hypertension. | RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia.
Herbert LM, Resta TC, Jernigan NL., Free PMC Article | 03/2/2019 |
| Together, the results of this study reveal a novel mechanism through which RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton. | RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton.
Tang L, Dai F, Liu Y, Yu X, Huang C, Wang Y, Yao W. | 03/2/2019 |
| results indicate that RhoA plays a vital role in Schwann cell differentiation via JNK pathway rather than ROCK pathway. | RhoA regulates Schwann cell differentiation through JNK pathway.
Wen J, Tan D, Li L, Wang X, Pan M, Guo J. | 02/23/2019 |
| chronic intermittent hypoxia-induced elevation of blood pressure is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway | The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.
Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S. | 11/17/2018 |
| RhoA/ROCK pathway plays a role in adhesion molecule expression and inflammatory cell infiltration in glomerular endothelial cells induced by advanced glycation end products | The RhoA/ROCK Pathway Ameliorates Adhesion and Inflammatory Infiltration Induced by AGEs in Glomerular Endothelial Cells.
Rao J, Ye Z, Tang H, Wang C, Peng H, Lai W, Li Y, Huang W, Lou T., Free PMC Article | 11/3/2018 |