| Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2-integrin beta1 complex. | Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex.
Hu S, Li Z, Liu H, Cao W, Meng Y, Liu C, He S, Lin Q, Shang M, Lin F, Yi N, Wang H, Sachinidis A, Ying Q, Li L, Peng L., Free PMC Article | 01/10/2024 |
| ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis. | ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis.
Xu W, Dahlke SP, Sung M, Samal B, Emery AC, Elkahloun A, Eiden LE., Free PMC Article | 10/8/2022 |
| ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. | ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling.
Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L, Peng L. | 12/4/2021 |
| Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats. | Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.
Zhao C, Chang L, Auger AP, Gammie SC, Riters LV., Free PMC Article | 07/17/2021 |
| Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells. | Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells.
Hajimirzaei N, Khalili NP, Boroumand B, Safari F, Pourhosseini A, Judi-Chelan R, Tavakoli F. | 06/5/2021 |
| Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. | Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction.
Li Z, Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L, Peng L., Free PMC Article | 02/13/2021 |
| Anti-Ro52 antibody acts on the hERG S5-pore linker to chronically decrease hERG expression and current. | Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression.
Szendrey J, Lamothe SM, Vanner S, Guo J, Yang T, Li W, Davis J, Joneja M, Baranchuk A, Zhang S., Free PMC Article | 06/27/2020 |
| PKD1 mediates the PKC effects on KV11.1 and we found that PKD targets S284 in the N-terminus of the channel. | PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.
Steffensen AB, Bomholtz SH, Andersen MN, Olsen JV, Mutsaers N, Lundegaard PR, Lundby A, Schmitt N. | 08/18/2018 |
| Allosteric modulation of the Kv11.1 channel efficiently suppresses drug-induced ventricular arrhythmias in vitro by preventing potentially arrhythmogenic changes in action potential characteristics | Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias.
Yu Z, Liu J, van Veldhoven JP, IJzerman AP, Schalij MJ, Pijnappels DA, Heitman LH, de Vries AA. | 08/6/2016 |
| SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling. | The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
Lamothe SM, Zhang S., Free PMC Article | 08/10/2013 |
| hERG expression in the plasma membrane is regulated by Cav3 via Nedd4-2 | Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2.
Guo J, Wang T, Li X, Shallow H, Yang T, Li W, Xu J, Fridman MD, Yang X, Zhang S., Free PMC Article | 12/22/2012 |
| KCNH-2 and KCNE-2 potassium channels are molecular subunits of an inwardly rectifying potassium channel complex. | The stoichiometric relationship between KCNH-2 and KCNE-2 in I(Kr) channel formation.
Kim DG, Oh JH, Lee EH, Lee JH, Park HJ, Kim CY, Kwon MS, Yoon S. | 10/8/2011 |
| Overexpression of Cav1 accelerated internalization of mature hERG channels in 0 mM K(+)(o), whereas knockdown of Cav1 impeded this process. | Involvement of caveolin in low K+-induced endocytic degradation of cell-surface human ether-a-go-go-related gene (hERG) channels.
Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S., Free PMC Article | 09/20/2010 |
| The ERG1 displays a heterogeneous distribution in the rat kidney. | Expression and immunolocalization of ERG1 potassium channels in the rat kidney.
Carrisoza R, Salvador C, Bobadilla NA, Trujillo J, Escobar LI. | 04/12/2010 |
| Kcnh2 (Erg1) is expressed in rat pancreatic beta cells. Pharmacological channel blockers indicate a function within the insulin secretion process. Differential expression of Erg1 splice variants a and b in alpha and beta cells was detected. | Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell.
Mühlbauer E, Bazwinsky I, Wolgast S, Klemenz A, Peschke E., Free PMC Article | 09/5/2008 |
| thyrotropin-releasing hormone (TRH) effects on the biophysical properties of homomeric erg1b and heteromeric erg1a/1b channels; most effects of TRHon heteromeric rerg1 channels were dominated by the rerg1b subunit | Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit.
Kirchberger NM, Wulfsen I, Schwarz JR, Bauer CK., Free PMC Article | 01/21/2010 |
| The localization of ERG1 to the transverse tubular system close to the Ca(2+) channels renders it with maximal repolarizing effect | Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.
Rasmussen HB, Møller M, Knaus HG, Jensen BS, Olesen SP, Jørgensen NK. | 01/21/2010 |
| Regulation of an ERG K+ current by Src tyrosine kinase. | Regulation of an ERG K+ current by Src tyrosine kinase.
Cayabyab FS, Schlichter LC. | 01/21/2010 |