| Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation. | Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation.
Tóth D, Simon G, Reglődi D., Free PMC Article | 11/2/2023 |
| Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research. | Calcitonin/PAC(1) receptor splice variants: a blind spot in migraine research.
Rees TA, Labastida-Ramírez A, Rubio-Beltrán E., Free PMC Article | 10/26/2023 |
| Distribution of PACAP and PAC1 Receptor in the Human Eye. | Distribution of PACAP and PAC1 Receptor in the Human Eye.
Patko E, Szabo E, Toth D, Tornoczky T, Bosnyak I, Vaczy A, Atlasz T, Reglodi D., Free PMC Article | 12/17/2022 |
| PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. | PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Tasma Z, Siow A, Harris PWR, Brimble MA, O'Carroll SJ, Hay DL, Walker CS., Free PMC Article | 12/10/2022 |
| PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients. | PACAP-38 and PAC1 Receptor Alterations in Plasma and Cardiac Tissue Samples of Heart Failure Patients.
Szabó D, Sárszegi Z, Polgár B, Sághy É, Reglődi D, Tóth T, Onódi Z, Leszek P, Varga ZV, Helyes Z, Kemény Á, Ferdinandy P, Tamás A., Free PMC Article | 04/23/2022 |
| The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3. | The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.
Moody TW, Lee L, Jensen RT., Free PMC Article | 01/8/2022 |
| GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex. | GIP receptor suppresses PAC1receptor-mediated neuronal differentiation via formation of a receptor heterocomplex.
Ke R, Lok SIS, Singh K, Chow BKC, Lee LTO. | 08/28/2021 |
| Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y., Free PMC Article | 07/24/2021 |
| Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex. | Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.
Jovanovic T, Stenson AF, Thompson N, Clifford A, Compton A, Minton S, van Rooij SJF, Stevens JS, Lori A, Nugent N, Gillespie CF, Bradley B, Ressler KJ., Free PMC Article | 06/26/2021 |
| Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study. | Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study.
Ross RA, Hoeppner SS, Hellberg SN, O'Day EB, Rosencrans PL, Ressler KJ, May V, Simon NM., Free PMC Article | 05/29/2021 |
| Data indicate the localization of adenylate cyclase activating polypeptide 1 (PACAP), its receptor PACAP type I receptor (PAC1R) and epidermal growth factor receptor (EGFR) in human corneal endothelium. | PACAP through EGFR transactivation preserves human corneal endothelial integrity.
Maugeri G, D'Amico AG, Castrogiovanni P, Saccone S, Federico C, Reibaldi M, Russo A, Bonfiglio V, Avitabile T, Longo A, D'Agata V. | 07/25/2020 |
| Molecular structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein has been reported. | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O. | 04/18/2020 |
| PAC1R encodes a receptor for pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family. | PAC1R Genotype to Phenotype Correlations in Autism Spectrum Disorder.
Goodrich M, Armour AC, Panchapakesan K, You X, Devaney J, Knoblach S, Sullivan CAW, Herrero MJ, Gupta AR, Vaidya CJ, Kenworthy L, Corbin JG., Free PMC Article | 02/29/2020 |
| Transitions between different conformational states of the G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) range between microseconds to milliseconds. | Conformational Transitions of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor, a Human Class B GPCR.
Liao C, Zhao X, Brewer M, May V, Li J., Free PMC Article | 02/2/2019 |
| that perturbations in the PACAP-PAC1R pathway may be involved in amyotrophic lateral sclerosis pathology | PACAP and PAC1R are differentially expressed in motor cortex of amyotrophic lateral sclerosis patients and support survival of iPSC-derived motor neurons.
Bonaventura G, Iemmolo R, D'Amico AG, La Cognata V, Costanzo E, Zappia M, D'Agata V, Conforti FL, Aronica E, Cavallaro S. | 12/22/2018 |
| These results show that b-arrestin1 and b-arrestin2 exert differential actions on PAC1R internalization and PAC1R-dependent ERK1/2 activation, and suggest that the two b-arrestin isoforms may be involved in fine and precise tuning of the PAC1R signaling pathways. | β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H., Free PMC Article | 08/4/2018 |
| Studies suggest that the level of stress and circulating gonadal hormones may differentially regulate the PACAPergic system in males and females to influence anxiety-like behavior and may be one mechanism underlying the discrepancies in human psychiatric disorders. [Review Article] | Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones.
King SB, Toufexis DJ, Hammack SE., Free PMC Article | 06/16/2018 |
| These results provide evidence for an association between ADCYAP1R1 and PTSD and indicate that there may indeed be sex differences. | Association of Posttraumatic Stress Disorder With rs2267735 in the ADCYAP1R1 Gene: A Meta-Analysis.
Lind MJ, Marraccini ME, Sheerin CM, Bountress K, Bacanu SA, Amstadter AB, Nugent NR., Free PMC Article | 05/19/2018 |
| These findings lead to a model in which E2 induces the expression of ADCYAP1R1 through binding of ERalpha at the ERE as an adaptive response to stress. Inhibition of E2/ERalpha binding to the ERE containing the rs2267735 risk allele results in reduced expression of ADCYAP1R1, diminishing estrogen regulation as an adaptive stress response and increasing risk for PTSD. | Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1.
Mercer KB, Dias B, Shafer D, Maddox SA, Mulle JG, Hu P, Walton J, Ressler KJ., Free PMC Article | 12/9/2017 |
| Data suggest that GCGR (glucagon receptor) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR or PAC1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling. | Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors.
Yin Y, de Waal PW, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE., Free PMC Article | 07/8/2017 |
| Results confirmed for the first time that doxycycline specially targeted pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1) imitating PACAP(30-37) and acted as an enhancer by facilitating the subsequent ligand binding and the activation of PAC1. | Doxycycline exerted neuroprotective activity by enhancing the activation of neuropeptide GPCR PAC1.
Yu R, Zheng L, Cui Y, Zhang H, Ye H. | 12/17/2016 |
| Rsults suggest that impaired contextual conditioning in the hippocampal formation may mediate the association between type I receptor of the pituitary adenylate cyclase activating polypeptideand and posttraumatic stress disorder symptoms. | Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide.
Pohlack ST, Nees F, Ruttorf M, Cacciaglia R, Winkelmann T, Schad LR, Witt SH, Rietschel M, Flor H. | 08/27/2016 |
| Data show that glucocorticoid response genes NR3C1, ADCYAP1R1 and HSD11B2 were relatively hypomethylated whereas FKBP5 was hypermethylated. | Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment.
Paquette AG, Lester BM, Lesseur C, Armstrong DA, Guerin DJ, Appleton AA, Marsit CJ., Free PMC Article | 08/13/2016 |
| Further investigations of genetic factors for trauma-related psychopathology should include careful assessments of the social environment | Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women.
Lowe SR, Pothen J, Quinn JW, Rundle A, Bradley B, Galea S, Ressler KJ, Koenen KC., Free PMC Article | 06/4/2016 |
| High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced bronchodilator response in children with asthma. | Stress and Bronchodilator Response in Children with Asthma.
Brehm JM, Ramratnam SK, Tse SM, Croteau-Chonka DC, Pino-Yanes M, Rosas-Salazar C, Litonjua AA, Raby BA, Boutaoui N, Han YY, Chen W, Forno E, Marsland AL, Nugent NR, Eng C, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Spear ML, Martinez FD, Avila L, Weiss ST, Soto-Quiros M, Ober C, Nicolae DL, Barnes KC, Lemanske RF Jr, Strunk RC, Liu A, London SJ, Gilliland F, Sleiman P, March M, Hakonarson H, Duan QL, Kolls JK, Fritz GK, Hu D, Fani N, Stevens JS, Almli LM, Burchard EG, Shin J, McQuaid EL, Ressler K, Canino G, Celedón JC., Free PMC Article | 09/12/2015 |