| The Dynamic Interactions of a Multitargeting Domain in Ameloblastin Protein with Amelogenin and Membrane. | The Dynamic Interactions of a Multitargeting Domain in Ameloblastin Protein with Amelogenin and Membrane.
Kegulian NC, Langen R, Moradian-Oldak J., Free PMC Article | 03/2/2023 |
| Ameloblastin is critical for the initiation of enamel ribbon formation, and its absence results in pathological mineralization within the enamel organ epithelia. | AMBN mutations causing hypoplastic amelogenesis imperfecta and Ambn knockout-NLS-lacZ knockin mice exhibiting failed amelogenesis and Ambn tissue-specificity.
Liang T, Hu Y, Smith CE, Richardson AS, Zhang H, Yang J, Lin B, Wang SK, Kim JW, Chun YH, Simmer JP, Hu JC., Free PMC Article | 06/20/2020 |
| polymorphisms in Ambn, Col14a1, and Mmp20 are associated with the susceptibility to dental fluorosis | Analysis of Polymorphisms in Genes Differentially Expressed in the Enamel of Mice with Different Genetic Susceptibilities to Dental Fluorosis.
Charone S, Küchler EC, Leite AL, Silva Fernandes M, Taioqui Pelá V, Martini T, Brondino BM, Magalhães AC, Dionisio TJ, F Santos C, Buzalaf MAR. | 12/14/2019 |
| Data demonstrate the functional importance of the AMBN extracellular matrix protein in bone fracture prevention and rapid fracture healing. | The ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing.
Lu X, Li W, Fukumoto S, Yamada Y, Evans CA, Diekwisch T, Luan X., Free PMC Article | 12/23/2017 |
| AMBN facilitates rapid long bone growth and an important growth spurt during the skeletogenesis of adolescent tooth-bearing vertebrates | Ameloblastin, an Extracellular Matrix Protein, Affects Long Bone Growth and Mineralization.
Lu X, Fukumoto S, Yamada Y, Evans CA, Diekwisch TG, Luan X. | 12/23/2017 |
| Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel. | Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel.
Geng S, White SN, Paine ML, Snead ML., Free PMC Article | 11/28/2015 |
| AMBN may function as a growth factor-like molecule solubilized in the aqueous microenvironment. In jaws, it might play a role in bone physiology through autocrine/paracrine pathways, particularly during development and stress-induced remodeling. | Tracking endogenous amelogenin and ameloblastin in vivo.
Jacques J, Hotton D, De la Dure-Molla M, Petit S, Asselin A, Kulkarni AB, Gibson CW, Brookes SJ, Berdal A, Isaac J., Free PMC Article | 10/24/2015 |
| Ameloblastin (AMBN) expression may be regulated in a site-specific manner and identify AMBN as a putative in vivo marker of the site-specific fingerprint of bone organs | Ameloblastin as a putative marker of specific bone compartments.
Jacques J, Hotton D, Asselin A, De la Dure-Molla M, Coudert AE, Isaac J, Berdal A. | 08/15/2015 |
| Ambn plays a crucial role in the regulation of cranial bone growth and suture closure via Msx 2 suppression and proliferation inhibition. | Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation.
Atsawasuwan P, Lu X, Ito Y, Zhang Y, Evans CA, Luan X., Free PMC Article | 11/16/2013 |
| Blocking integrin alpha2beta1 and ERK 1/2 pathways alleviated the effects of AMBN on osteoclast differentiation. | Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway.
Lu X, Ito Y, Atsawasuwan P, Dangaria S, Yan X, Wu T, Evans CA, Luan X., Free PMC Article | 09/7/2013 |
| ERP expression follows defined developmental profiles; affects osteoblast differentiation, mineralization, calvarial bone development. with role in developing enamel matrix, ERPs retain conserved function related to bone biomineralization. | Expression and function of enamel-related gene products in calvarial development.
Atsawasuwan P, Lu X, Ito Y, Chen Y, Gopinathan G, Evans CA, Kulkarni AB, Gibson CW, Luan X, Diekwisch TG., Free PMC Article | 08/31/2013 |
| AMBN may regulate differentiation state of Hertwig's epithelial root sheath-derived cells and its expression fuctions as a trigger for normal root formation. | Ameloblastin in Hertwig's epithelial root sheath regulates tooth root formation and development.
Hirose N, Shimazu A, Watanabe M, Tanimoto K, Koyota S, Sugiyama T, Uchida T, Tanne K., Free PMC Article | 07/27/2013 |
| All lines expressing detectable levels of ameloblastin at least partially recovered the enamel phenotype. Ameloblastin is essential for dental enamel formation. | Transgenic rescue of enamel phenotype in Ambn null mice.
Chun YH, Lu Y, Hu Y, Krebsbach PH, Yamada Y, Hu JC, Simmer JP., Free PMC Article | 01/1/2011 |
| Results indicate that absence of full-length ameloblastin and/or expression of an incomplete protein have direct/indirect effects beyond structuring of mineral during enamel formation. | A mouse model expressing a truncated form of ameloblastin exhibits dental and junctional epithelium defects.
Wazen RM, Moffatt P, Zalzal SF, Yamada Y, Nanci A., Free PMC Article | 01/21/2010 |
| Enamel matrix proteins such as amelogenins and ameloblastin are not only required for the formation of a proper matrix for well-orchestrated enamel biomineralization, but also have synergistic cellular functions during enamel development. | Synergistic roles of amelogenin and ameloblastin.
Hatakeyama J, Fukumoto S, Nakamura T, Haruyama N, Suzuki S, Hatakeyama Y, Shum L, Gibson CW, Yamada Y, Kulkarni AB., Free PMC Article | 01/21/2010 |
| the ameloblastin 37-kDa isoform interacts with amelogenin during early tooth development. | Spatiotemporal expression of ameloblastin isoforms during murine tooth development.
Ravindranath RM, Devarajan A, Uchida T. | 01/21/2010 |
| no mutation could be detected in the ameloblastin gene [in amelogenesis imperfecta] | A mutation in the enamelin gene in a mouse model.
Seedorf H, Klaften M, Eke F, Fuchs H, Seedorf U, Hrabe de Angelis M. | 01/21/2010 |
| Ameloblastin is an important regulator to maintain the differentiation state of ameloblasts. | Essential roles of ameloblastin in maintaining ameloblast differentiation and enamel formation.
Fukumoto S, Yamada A, Nonaka K, Yamada Y. | 01/21/2010 |
| Ameloblastin is a cell adhesion molecule essential for amelogenesis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by binding to ameloblasts and inhibiting proliferation. | Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts.
Fukumoto S, Kiba T, Hall B, Iehara N, Nakamura T, Longenecker G, Krebsbach PH, Nanci A, Kulkarni AB, Yamada Y., Free PMC Article | 01/21/2010 |
| study may implicate the role of the ameloblastin gene locus in the etiology of a number of undiagnosed autosomally dominant cases of amelogenesis imperfecta | A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression.
Paine ML, Wang HJ, Luo W, Krebsbach PH, Snead ML. | 01/21/2010 |