Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling.
Chen J, Zeng Q, Wang X, Xu R, Wang W, Huang Y, Sun Q, Yuan W, Wang P, Chen D, Tong P, Jin H., Free PMC Article

A miRNA-21-Mediated PTEN/Akt/NF-κB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis.
Sai X, Qin C, Zhang Z, Yu H, Bian T., Free PMC Article

Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell.
Verma M, Asakura Y, Wang X, Zhou K, Ünverdi M, Kann AP, Krauss RS, Asakura A., Free PMC Article

Peroxiredoxin 1 promotes proliferation and inhibits differentiation of MC3T3-E1 cells via AKT1 / NF-κB signaling pathway.
Du J, Zhou W, Sun Z, Zhang W, Luo W, Liu S.

PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis.
Xu X, Bok I, Jasani N, Wang K, Chadourne M, Mecozzi N, Deng O, Welsh EA, Kinose F, Rix U, Karreth FA., Free PMC Article

DNA-PKcs/AKT1 inhibits epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1.
Yan Z, Zhu J, Liu Y, Li Z, Liang X, Zhou S, Hou Y, Chen H, Zhou L, Wang P, Ao X, Gao S, Huang X, Zhou PK, Gu Y., Free PMC Article

Stage-specific regulation of undifferentiated spermatogonia by AKT1S1-mediated AKT-mTORC1 signaling during mouse spermatogenesis.
Yang L, Liao J, Huang H, Lee TL, Qi H.

Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
Juin A, Spence HJ, Machesky LM.

PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.
Chen H, Li L, Liu H, Qin P, Chen R, Liu S, Xiong H, Li Y, Yang Z, Xie M, Yang H, Jiang Q.

Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
Chen M, Wang G, Xu Z, Sun J, Liu B, Chang L, Gu J, Ruan Y, Gao X, Song S.

Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke.
Connelly JA, Zhang X, Chen Y, Chao Y, Shi Y, Jacob TC, Wang QJ., Free PMC Article

A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT).
Chen L, Lu Y, Zhao M, Xu J, Wang Y, Xu Q, Cao Y, Liu H.

Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Miao Y, Liu J.

Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
Ruiz-Rodríguez MJ, Oller J, Martínez-Martínez S, Alarcón-Ruiz I, Toral M, Sun Y, Colmenar Á, Méndez-Olivares MJ, López-Maderuelo D, Kern CB, Nistal JF, Evangelista A, Teixido-Tura G, Campanero MR, Redondo JM., Free PMC Article

SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Xu K, Fei W, Gao W, Fan C, Li Y, Hong Y, Cui R.

Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Bracho-Valdés I, Cervantes-Villagrana RD, Beltrán-Navarro YM, Olguín-Olguín A, Escobar-Islas E, Carretero-Ortega J, Olivares-Reyes JA, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J., Free PMC Article

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.
Mi S, Zhang J, Sun M, Huo X, Lv Y, Beier F, Lu S, Yan J.

Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing.
Mishra AK, Rodriguez M, Torres AY, Smith M, Rodriguez A, Bond A, Morrissey MA, Montell DJ., Free PMC Article

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Qiu Y, Meng Y, Jia Y, Lang X, Zhao H, Ding L, Wang T, Sun H, Gao S.

A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration.
Na D, Lim DH, Hong JS, Lee HM, Cho D, Yu MS, Shaker B, Ren J, Lee B, Song JG, Oh Y, Lee K, Oh KS, Lee MY, Choi MS, Choi HS, Kim YH, Bui JM, Lee K, Kim HW, Lee YS, Gsponer J., Free PMC Article

FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway.
Yin L, Cao R, Liu Z, Luo G, Li Y, Zhou X, Chen X, Wu Y, He J, Zu X, Shen Y., Free PMC Article

SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling.
Yu H, Zhou L, Loong JHC, Lam KH, Wong TL, Ng KY, Tong M, Ma VWS, Wang Y, Zhang X, Lee TK, Yun JP, Yu J, Ma S.

MenSCs Transplantation Improve the Viability of Injured Endometrial Cells Through Activating PI3K/Akt Pathway.
Zhang S, Zhang R, Yin X, Lu Y, Cheng H, Pan Y, Liu Y, Lin J.

Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3β/β-catenin/Bcl-2 Pathway.
Li S, Li Y, Huang P, Mao X, Jiang K, Chen R, Li Q, Wang L, Jin Z, Wan C, Xiong Y, Yu Y, Sheng W, Hong D, Lin J.

RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling.
Hu S, Zhang Y, Qiu C, Li Y.