| Regulation of the Glycine Transporter GLYT1 by microRNAs. | Regulation of the Glycine Transporter GLYT1 by microRNAs.
Jiménez E, Piniella D, Giménez C, Zafra F. | 04/9/2022 |
| Study demonstrated a biphasic response of GlyT1 expression during epileptogenesis with initial downregulation of GlyT1 after epileptogenesis-precipitating seizures followed by sustained pathological overexpression of GlyT1 in chronic epilepsy | Glycine transporter 1 is a target for the treatment of epilepsy.
Shen HY, van Vliet EA, Bright KA, Hanthorn M, Lytle NK, Gorter J, Aronica E, Boison D., Free PMC Article | 09/3/2016 |
| Study showed that glycine uptake mediated by GlyT1 and GlyT2 in astrocytes is modulated by BDNF | BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes.
Aroeira RI, Sebastião AM, Valente CA. | 07/30/2016 |
| astrocytes express functional GlyT2, which challenge previous findings that those cells would express only GlyT1 | GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function.
Aroeira RI, Sebastião AM, Valente CA. | 02/7/2015 |
| Double labeling for GLYT1 and synaptophysin of this vesicular fraction revealed that more of ninety percent of them were synaptic vesicles | Localization of the glycine transporter GLYT1 in glutamatergic synaptic vesicles.
Cubelos B, Leite C, Giménez C, Zafra F. | 02/7/2015 |
| Inhibition of GlyT1 reduces the frequency of spontaneous network events in the hippocampus. | Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus.
Sipilä ST, Spoljaric A, Virtanen MA, Hiironniemi I, Kaila K., Free PMC Article | 09/27/2014 |
| Glycine transport by GLYT1 is inhibited by lithium whereas GLYT2 transport is stimulated, and this effect is more evident at increased glycine concentrations. | Molecular basis of the differential interaction with lithium of glycine transporters GLYT1 and GLYT2.
Pérez-Siles G, Morreale A, Leo-Macías A, Pita G, Ortíz AR, Aragón C, López-Corcuera B. | 09/3/2011 |
| study analyzed transient currents of recombinant GlyT1b variant protein and related their properties to characteristics of steady transport currents; numerical simulations show a simplified, 3-state model explains main features of GlyT1b operation | Transient currents in the glycine cotransporter GlyT1 reveal different steps in transport mechanism.
Cherubino F, Bossi E, Miszner A, Ghezzi C, Peres A. | 07/12/2010 |
| In conclusion, GlyT1 most likely mediates glycine transport at the inner BRB and is expected to play an important role in regulating the glycine concentration in the neural retina. | Characteristics of glycine transport across the inner blood-retinal barrier.
Okamoto M, Akanuma S, Tachikawa M, Hosoya K. | 02/1/2010 |
| Results show that endocytosis is impaired in an ubiquitination-deficient cell line. | Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination.
Fernández-Sánchez E, Martínez-Villarreal J, Giménez C, Zafra F., Free PMC Article | 01/21/2010 |
| Together, these results suggest PKCalpha to be a crucial factor in the regulation of glycine transport in C6 cells. | The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.
Morioka N, Abdin JM, Morita K, Kitayama T, Nakata Y, Dohi T. | 01/21/2010 |
| These data support that treatment with a glycine transporter inhibitor can ameliorate deficits in both LTP and learning that occur in a rat model of psychosis, and may prove a useful strategy to address cognitive disruption in psychotic illnesses. | Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1).
Manahan-Vaughan D, Wildförster V, Thomsen C. | 01/21/2010 |
| Data show that dense GLYT1 expression is localized to superficial layer of microgyric cortex and around the microgyrus in the rat model of cortical dysplasia. | Glycine transporter-1 expression in the rat model of cortical dysplasia.
Aykut-Bingol C, Tuncer N, Kaya H, Ekicioglu G. | 01/21/2010 |
| Data show the retina 1 expression of glycine transporter 1 in rats. | Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina.
Peña-Rangel MT, Riesgo-Escovar JR, Sánchez-Chávez G, Salceda R. | 01/21/2010 |
| post-translational mechanisms are of primary importance in elevating glycine transporter 1 protein levels following transient ischemia | Immunohistochemical and in situ hybridization studies on glycine transporter 1 after transient ischemia in the rat forebrain.
Kalló I, Jekkel C, Hrabovszky E, Jurányi Z, Vida B, Járási A, Wilheim T, Harsing LG Jr, Liposits Z. | 01/21/2010 |
| These data underline the in vivo implication of the glycine uptake mechanism in the control of subcortical glutamate/dopamine interactions. | 2-Chloro-N-[(S)-phenyl [(2S)-piperidin-2-yl] methyl]-3-trifluoromethyl benzamide, monohydrochloride, an inhibitor of the glycine transporter type 1, increases evoked-dopamine release in the rat nucleus accumbens in vivo via an enhanced glutamatergic neurotransmission.
Leonetti M, Desvignes C, Bougault I, Souilhac J, Oury-Donat F, Steinberg R. | 01/21/2010 |
| findings suggest that loss of expression of the Glyt-1 transporter may cause an impairment of regulation of glycine concentration at synaptic level and contribute to an overactivation of the NMDA receptor in acute liver failure | Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure.
Zwingmann C, Desjardins P, Hazell A, Chatauret N, Michalak A, Butterworth RF. | 01/21/2010 |
| the close spatial association of GLYT1 and glutamatergic synapses strongly supports a role for this protein in neurotransmission | Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain.
Cubelos B, Giménez C, Zafra F. | 01/21/2010 |