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    OLIG1 oligodendrocyte transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 116448, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin.

    Olig1 is required for noggin-induced neonatal myelin repair.
    Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH., Free PMC Article

    07/22/2017
    This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder.

    Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
    Rajkowska G, Mahajan G, Maciag D, Sathyanesan M, Iyo AH, Moulana M, Kyle PB, Woolverton WL, Miguel-Hidalgo JJ, Stockmeier CA, Newton SS., Free PMC Article

    01/30/2016
    Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility

    Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.
    Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K., Free PMC Article

    09/14/2013
    This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states.

    Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
    Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH., Free PMC Article

    01/26/2013
    Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance.

    Olig1 is expressed in human oligodendrocytes during maturation and regeneration.
    Othman A, Frim DM, Polak P, Vujicic S, Arnason BG, Boullerne AI.

    03/31/2012
    analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus

    A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.
    Friedli M, Barde I, Arcangeli M, Verp S, Quazzola A, Zakany J, Lin-Marq N, Robyr D, Attanasio C, Spitz F, Duboule D, Trono D, Antonarakis SE., Free PMC Article

    07/9/2011
    Observational study of gene-disease association. (HuGE Navigator)

    A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.
    Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, Perlis R, Leboyer M, Delorme R, Chabane N, Rauch SL, Jenike MA, Pauls DL.

    03/13/2008
    No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression.

    Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.
    Takei H, Yogeswaren ST, Wong KK, Mehta V, Chintagumpala M, Dauser RC, Lau CC, Adesina AM.

    01/21/2010
    OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients

    Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.
    Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C., Free PMC Article

    01/21/2010
    Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification.

    Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.
    Jakovcevski I, Zecevic N., Free PMC Article

    01/21/2010
    Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders.

    Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy.
    Ruf N, Martelli M, Weschke B, Uhlenberg B.

    01/21/2010
    identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis

    Novel Olig 1-coding variants and susceptibility to multiple sclerosis.
    Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S., Free PMC Article

    01/21/2010
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