Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice. | Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice. Sidheeque Hassan V, Hanifa M, Navik U, Bali A. | 08/25/2023 |
FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway. | FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway. Nag S, Mandal S, Majumdar T, Mukhopadhyay S, Kundu R. | 03/2/2023 |
Blocking TLR4-NF-kappaB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion. | Blocking TLR4-NF-κB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion. Mukhuty A, Fouzder C, Kundu R. | 12/25/2021 |
Fetuin-A secretion from beta-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion. | Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion. Mukhuty A, Fouzder C, Kundu R. | 12/18/2021 |
Increase in PPARgamma inhibitory phosphorylation by Fetuin-A through the activation of Ras-MEK-ERK pathway causes insulin resistance. | Increase in PPARγ inhibitory phosphorylation by Fetuin-A through the activation of Ras-MEK-ERK pathway causes insulin resistance. Das S, Chattopadhyay D, Chatterjee SK, Mondal SA, Majumdar SS, Mukhopadhyay S, Saha N, Velayutham R, Bhattacharya S, Mukherjee S. | 07/3/2021 |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress. | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress. Rudloff S, Janot M, Rodriguez S, Dessalle K, Jahnen-Dechent W, Huynh-Do U., Free PMC Article | 02/13/2021 |
Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model. | Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model. Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K. | 08/22/2020 |
Soft tissue calcification can start by intravascular mineral deposition causing microvasculopathy in Ahsg -/- mouse, which impacts on growth, organ function and survival. | Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity. Herrmann M, Babler A, Moshkova I, Gremse F, Kiessling F, Kusebauch U, Nelea V, Kramann R, Moritz RL, McKee MD, Jahnen-Dechent W., Free PMC Article | 05/9/2020 |
Fetuin-A mediates hepatotoxicity of acetaminophen-induced liver injury through infiltration of monocytes into the liver. | Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice. Lee KY, Lee W, Jung SH, Park J, Sim H, Choi YJ, Park YJ, Chung Y, Lee BH. | 04/4/2020 |
Other HBPs such as alpha 2-HS glycoprotein (AHSG) and histidine-rich glycoprotein (HRG) need further investigation for potential applications in the management of Acute pancreatitis (AP) . Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP. | The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. Nunes QM, Su D, Brownridge PJ, Simpson DM, Sun C, Li Y, Bui TP, Zhang X, Huang W, Rigden DJ, Beynon RJ, Sutton R, Fernig DG., Free PMC Article | 02/22/2020 |
The phosphorylation status of Fet-A (Ser312) is associated with obesity and insulin resistance and raise the possibility that Fet-A phosphorylation may play a role in regulation of insulin action. | Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance. Ren G, Kim T, Papizan JB, Okerberg CK, Kothari VM, Zaid H, Bilan PJ, Araya-Ramirez F, Littlefield LA, Bowers RL, Mahurin AJ, Nickles MM, Ludvigsen R, He X, Grandjean PW, Mathews ST. | 02/22/2020 |
both FGF23 and Fetuin-A are present and strictly linked to each other in MSCs with FGF23 driving Fetuin-A production. This mechanism suggests a role for these two proteins in the osteoblast differentiation. | FGF23 and Fetuin-A Interaction and Mesenchymal Osteogenic Transformation. Mattinzoli D, Ikehata M, Tsugawa K, Alfieri CM, Barilani M, Lazzari L, Andreetta P, Elli FM, Mantovani G, Messa P., Free PMC Article | 06/8/2019 |
Downregulation of adiponectin in inflamed adipocyte by fetuin-A through the mediation of Wnt3a and PPARgamma is a new report. | Fetuin-A downregulates adiponectin through Wnt-PPARγ pathway in lipid induced inflamed adipocyte. Agarwal S, Chattopadhyay M, Mukherjee S, Dasgupta S, Mukhopadhyay S, Bhattacharya S. | 12/22/2018 |
FETUA expression and ER stress markers in the liver and serum of HFD mice were decreased by melatonin treatment. In conclusion, melatonin can improve hepatic insulin resistance and hepatic steatosis through reduction in ER stress and the resultant AHSG expression. | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. Heo JI, Yoon DW, Yu JH, Kim NH, Yoo HJ, Seo JA, Kim SG, Choi KM, Baik SH, Choi DS, Kim NH. | 11/17/2018 |
Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A. | Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A. Chattopadhyay M, Mukherjee S, Chatterjee SK, Chattopadhyay D, Das S, Majumdar SS, Mukhopadhyay S, Mukherjee S, Bhattarcharya S. | 07/21/2018 |
The growth plate slippage occurred in 70% of Ahsg-/- mice of both sexes around three weeks postnatal. | Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice. Brylka LJ, Köppert S, Babler A, Kratz B, Denecke B, Yorgan TA, Etich J, Costa IG, Brachvogel B, Boor P, Schinke T, Jahnen-Dechent W., Free PMC Article | 11/18/2017 |
AHSG is produced in bone, mainly in osteocytes and also show for the first time that its production is modulated by FGF23. | FGF23-regulated production of Fetuin-A (AHSG) in osteocytes. Mattinzoli D, Rastaldi MP, Ikehata M, Armelloni S, Pignatari C, Giardino LA, Li M, Alfieri CM, Regalia A, Riccardi D, Messa P. | 10/22/2016 |
These findings establish urinary Fetuin-A as a sensitive biomarker of the progression of autosomal dominant polycystic kidney disease. | Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression. Piazzon N, Bernet F, Guihard L, Leonhard WN, Urfer S, Firsov D, Chehade H, Vogt B, Piergiovanni S, Peters DJ, Bonny O, Constam DB., Free PMC Article | 03/19/2016 |
Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls. | Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification. Lau WL, Liu S, Vaziri ND. | 09/5/2015 |
fetuin-A regulates endochondral ossification through mineralization inhibition and lipid (hormone) binding [review] | The role of fetuin-A in physiological and pathological mineralization. Brylka L, Jahnen-Dechent W. | 05/17/2014 |
Our results show that CSF fetuin-A is a biomarker of disease activity and natalizumab response in multiple sclerosis | Cerebrospinal fluid fetuin-A is a biomarker of active multiple sclerosis. Harris VK, Donelan N, Yan QJ, Clark K, Touray A, Rammal M, Sadiq SA. | 04/19/2014 |
lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization | Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages. Chatterjee P, Seal S, Mukherjee S, Kundu R, Mukherjee S, Ray S, Mukhopadhyay S, Majumdar SS, Bhattacharya S., Free PMC Article | 12/28/2013 |
FetA, via its terminal galactoside moiety, directly binds Leu100-Gly123 & Thr493-Thr516 in Tlr4, fulfilling the requirement of an endogenous ligand for TLR4 through which lipids induce insulin resistance. | Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S. | 10/26/2013 |
Our results show that fetuin-A has a developmental rather than a structural role in murine bone. | Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice. Seto J, Busse B, Gupta HS, Schäfer C, Krauss S, Dunlop JW, Masic A, Kerschnitzki M, Zaslansky P, Boesecke P, Catalá-Lehnen P, Schinke T, Fratzl P, Jahnen-Dechent W., Free PMC Article | 03/30/2013 |
Fetuin-A-containing calciprotein particles facilitate the clearance of mineral debris by macrophages via SR-A. | Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Herrmann M, Schäfer C, Heiss A, Gräber S, Kinkeldey A, Büscher A, Schmitt MM, Bornemann J, Nimmerjahn F, Herrmann M, Helming L, Gordon S, Jahnen-Dechent W. | 11/3/2012 |