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    TNFRSF13C TNF receptor superfamily member 13C [ Homo sapiens (human) ]

    Gene ID: 115650, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    BAFFR expression in circulating T follicular helper (CD4[+]CXCR5[+]PD-1[+]) and T peripheral helper (CD4[+]CXCR5[-]PD-1[+]) cells in systemic lupus erythematosus.

    BAFFR expression in circulating T follicular helper (CD4(+)CXCR5(+)PD-1(+)) and T peripheral helper (CD4(+)CXCR5(-)PD-1(+)) cells in systemic lupus erythematosus.
    Sagrero-Fabela N, Ortíz-Lazareno PC, Salazar-Camarena DC, Cruz A, Cerpa-Cruz S, Muñoz-Valle JF, Marín-Rosales M, Alvarez-Gómez JA, Palafox-Sánchez CA.

    08/9/2023
    Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.

    Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.
    Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y., Free PMC Article

    07/10/2023
    CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.

    CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.
    Block V, Sevdali E, Recher M, Abolhassani H, Hammarstrom L, Smulski CR, Baronio M, Plebani A, Proietti M, Speletas M, Warnatz K, Voll RE, Lougaris V, Schneider P, Eibel H., Free PMC Article

    02/11/2023
    B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.

    B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.
    Gragnani L, Lorini S, Marri S, Rattotti S, Madia F, Zibellini S, Monti M, Basile U, Di Stasio E, Libra M, Arcaini L, Zignego AL., Free PMC Article

    10/15/2022
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.

    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.
    Sevdali E, Block V, Lataretu M, Li H, Smulski CR, Briem JS, Heitz Y, Fischer B, Ramirez NJ, Grimbacher B, Jäck HM, Voll RE, Hölzer M, Schneider P, Eibel H.

    07/9/2022
    Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjogren's Syndrome Patients at Diagnosis.

    Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjögren's Syndrome Patients at Diagnosis.
    Neys SFH, Verstappen GM, Bootsma H, Kroese FGM, Hendriks RW, Corneth OBJ., Free PMC Article

    05/28/2022
    Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA(+) Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM(+) Cell Signature.

    Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA(+) Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM(+) Cell Signature.
    Leffler J, Trend S, Ward NC, Grau GE, Hawke S, Byrne SN, Kermode AG, French MA, Hart PH., Free PMC Article

    05/21/2022
    A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.

    A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.
    Wong DP, Roy NK, Zhang K, Anukanth A, Asthana A, Shirkey-Son NJ, Dunmire S, Jones BJ, Lahr WS, Webber BR, Moriarity BS, Caimi P, Parameswaran R., Free PMC Article

    02/12/2022
    Editorial overview: BAFF family ligands and receptors - a license to live.

    Editorial overview: BAFF family ligands and receptors - a license to live.
    Jellusova J, Cancro MP, Eibel H.

    01/22/2022
    BAFF signaling in health and disease.

    BAFF signaling in health and disease.
    Schweighoffer E, Tybulewicz VL.

    01/22/2022
    BAFF receptor polymorphisms and deficiency in humans.

    BAFF receptor polymorphisms and deficiency in humans.
    Sevdali E, Block Saldana V, Speletas M, Eibel H.

    01/22/2022
    BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis.

    BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis.
    Prieto-Peña D, Genre F, Remuzgo-Martínez S, Pulito-Cueto V, Atienza-Mateo B, Llorca J, Sevilla-Pérez B, Ortego-Centeno N, Lera-Gómez L, Leonardo MT, Peñalba A, Narváez J, Martín-Penagos L, Rodrigo E, Miranda-Filloy JA, Caminal-Montero L, Collado P, Pérez JS, de Argila D, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Agirregoikoa E, Gualillo O, Martín J, Castañeda S, Blanco R, González-Gay MA, López-Mejías R., Free PMC Article

    11/6/2021
    Expression of BAFF and BAFF receptors in primary Sjogren's syndrome patients with ectopic germinal center-like structures.

    Expression of BAFF and BAFF receptors in primary Sjögren's syndrome patients with ectopic germinal center-like structures.
    Carrillo-Ballesteros FJ, Palafox-Sánchez CA, Franco-Topete RA, Muñoz-Valle JF, Orozco-Barocio G, Martínez-Bonilla GE, Gómez-López CE, Marín-Rosales M, López-Villalobos EF, Luquin S, Castañeda-Chávez A, Oregon-Romero E.

    08/14/2021
    Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sjogren's syndrome.

    Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sjögren's syndrome.
    Yoshimoto K, Suzuki K, Takei E, Ikeda Y, Takeuchi T., Free PMC Article

    08/7/2021
    The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern Italy.

    The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern Italy.
    Russo R, Andolfo I, Lasorsa VA, Cantalupo S, Marra R, Frisso G, Abete P, Cassese GM, Servillo G, Esposito G, Gentile I, Piscopo C, Della Monica M, Fiorentino G, Russo G, Cerino P, Buonerba C, Pierri B, Zollo M, Iolascon A, Capasso M., Free PMC Article

    07/10/2021
    Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma.

    Decreased of BAFF-R expression and B cells maturation in patients with hepatitis B virus-related hepatocellular carcinoma.
    Khlaiphuengsin A, Chuaypen N, Sodsai P, Buranapraditkun S, Boonpiyathad T, Hirankarn N, Tangkijvanich P., Free PMC Article

    04/3/2021
    TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis.

    TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis.
    Ntellas P, Dardiotis E, Sevdali E, Siokas V, Aloizou AM, Tsinti G, Germenis AE, Hadjigeorgiou GM, Eibel H, Speletas M.

    11/28/2020
    To evaluate the expression of the cytokines BAFF and APRIL and their association with the receptors BAFF-R and TACI on CD3+ T cells.

    BAFF-R and TACI expression on CD3+ T cells: Interplay among BAFF, APRIL and T helper cytokines profile in systemic lupus erythematosus.
    Salazar-Camarena DC, Ortíz-Lazareno P, Marín-Rosales M, Cruz A, Muñoz-Valle F, Tapia-Llanos R, Orozco-Barocio G, Machado-Contreras R, Palafox-Sánchez CA.

    03/28/2020
    these data indicate that BR3 neutralization increases the activation and cytolytic function of CD4 and CD8 cytotoxic T lymphocytes

    Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
    Bloom DD, Reshetylo S, Nytes C, Goodsett CT, Hematti P., Free PMC Article

    10/5/2019
    This study assessed TNFRSF13C expression on leukaemic cells ofchildhood B-cell precursor acute lymphoblastic leukaemia patients. Of note, during the early drug treatment, its expression is maintained or even increased on residual tumour cells, suggesting a positive selection and survival of TNFRSF13C positive blast cells.

    TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic leukaemia.
    Fazio G, Turazzi N, Cazzaniga V, Kreuzaler M, Maglia O, Magnani CF, Biagi E, Rolink A, Biondi A, Cazzaniga G.

    06/8/2019
    the B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration

    The B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration.
    Zhang L, Zhang F, Yang T, Zhu X, Zheng N, Li H, Zhu D, Zhu Y, Xu Z.

    11/3/2018
    Expression patterns of BAFF and its receptor BAFF-R differ according to lupus nephritis class.

    Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
    Suso JP, Posso-Osorio I, Jiménez CA, Naranjo-Escobar J, Ospina FE, Sánchez A, Cañas CA, Tobón GJ.

    09/29/2018
    up-regulated expression in intractable temporal lobe epilepsy

    Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.
    Ma L, Li R, Huang H, Yuan J, Ou S, Xu T, Yu X, Liu X, Chen Y.

    01/13/2018
    Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels.

    BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.
    Smulski CR, Kury P, Seidel LM, Staiger HS, Edinger AK, Willen L, Seidl M, Hess H, Salzer U, Rolink AG, Rizzi M, Schneider P, Eibel H.

    12/2/2017
    Relationships between serum BAFF and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI) and B cell maturation antigen (BCMA)] were determined on B cell subsets, defined using immunoglobulin (Ig)D/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included.

    B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets.
    Becerra E, De La Torre I, Leandro MJ, Cambridge G., Free PMC Article

    11/26/2017
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