| Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury. | Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury.
Xu Y, Tang L, Zhou C, Sun L, Hu Y, Zhang Z, Xia S, Bao X, Yang H, Xu Y., Free PMC Article | 05/9/2024 |
| The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4(+) T Cells. | The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
Micheli L, Durante M, Lucarini E, Sgambellone S, Lucarini L, Di Cesare Mannelli L, Ghelardini C, Masini E., Free PMC Article | 01/22/2022 |
| Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. | Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10.
Durante M, Squillace S, Lauro F, Giancotti LA, Coppi E, Cherchi F, Di Cesare Mannelli L, Ghelardini C, Kolar G, Wahlman C, Opejin A, Xiao C, Reitman ML, Tosh DK, Hawiger D, Jacobson KA, Salvemini D., Free PMC Article | 10/2/2021 |
| Dual Actions of A2A and A3 Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice. | Dual Actions of A(2A) and A(3) Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice.
Pak ES, Jeong LS, Hou X, Tripathi SK, Lee J, Ha H., Free PMC Article | 06/19/2021 |
| Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. | Adenosine A(2A) and A(3) Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling.
Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R., Free PMC Article | 02/20/2021 |
| the findings of this study demonstrate that Namodenoson exerts an antiNASH effect mediated via the deregulation of the PI3K/NFkappaB/Wnt/betacatenin signaling pathway. Thus, targeting A3AR may prove to be a novel direction in the pharmacotherapy of NAFLD/NASH. | The A3 adenosine receptor agonist, namodenoson, ameliorates non‑alcoholic steatohepatitis in mice.
Fishman P, Cohen S, Itzhak I, Amer J, Salhab A, Barer F, Safadi R., Free PMC Article | 04/18/2020 |
| Our studies show for the first time that A3R signaling plays an important role in regulating age-related osteoarthritis. | Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration.
Shkhyan R, Lee S, Gullo F, Li L, Peleli M, Carlstrom M, Chagin AS, Banks NW, Limfat S, Liu NQ, Evseenko D., Free PMC Article | 11/9/2019 |
| Reduction in nephron number combined with chronic HS intake is associated with oxidative stress, chronic inflammation, and development of hypertension in mice. Absence of adenosine A3 receptor signaling was strongly protective in this novel mouse model of renal and cardiovascular disease. | Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.
Yang T, Zollbrecht C, Winerdal ME, Zhuge Z, Zhang XM, Terrando N, Checa A, Sällström J, Wheelock CE, Winqvist O, Harris RA, Larsson E, Persson AE, Fredholm BB, Carlström M., Free PMC Article | 01/6/2018 |
| these data demonstrate the involvement of macrophage A3Rs in the proper chemotactic navigation and consequent in vivo clearance of apoptotic cells. Interestingly, loss of A3Rs did not affect the in vivo clearance of apoptotic thymocytes in the dexamethasone-treated thymus. | Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells.
Joós G, Jákim J, Kiss B, Szamosi R, Papp T, Felszeghy S, Sághy T, Nagy G, Szondy Z. | 12/9/2017 |
| Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point. | Hypothermia in mouse is caused by adenosine A(1) and A(3) receptor agonists and AMP via three distinct mechanisms.
Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML., Free PMC Article | 07/15/2017 |
| Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration | Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration.
Koszałka P, Gołuńska M, Urban A, Stasiłojć G, Stanisławowski M, Majewski M, Składanowski AC, Bigda J., Free PMC Article | 07/30/2016 |
| A3AR knockout mice had higher survival rates following lethal doses of gamma-radiation than wild type mice. | Enhanced survival of lethally irradiated adenosine A3 receptor knockout mice. A role for hematopoietic growth factors?
Hofer M, Pospíšil M, Dušek L, Hoferová Z, Komůrková D., Free PMC Article | 12/5/2015 |
| during phagocytosis of apoptotic cells the expression of A2ARs increases, while that of A3Rs decreases, on long term adenosine suppresses the proinflammatory responses in engulfing macrophages. | Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation.
Duró E, Pallai A, Köröskényi K, Sarang Z, Szondy Z. | 08/1/2015 |
| Increased values of bone marrow parameters were found in femoral bone marrow from adenosine A3 receptor-knock out mice. | Lack of adenosine A3 receptors causes defects in mouse peripheral blood parameters.
Hofer M, Pospíšil M, Dušek L, Hoferová Z, Komůrková D., Free PMC Article | 06/20/2015 |
| These studies reveal A3AR activation by adenosine as an endogenous anti-nociceptive pathway and support the development of A3AR agonists as novel therapeutics to treat chronic pain. | Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, Salvemini D., Free PMC Article | 03/7/2015 |
| The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling. | Erythropoiesis- and thrombopoiesis-characterizing parameters in adenosine A3 receptor knock-out mice.
Hofer M, Pospíšil M, Dušek L, Hoferová Z, Weiterová L, Komůrková D. | 04/26/2014 |
| Adenosin inhibited Lipopolysaccharide-increased HIF1alpha accumulation under both normoxic and hypoxic conditions, through activation of A1 and A3 adenosine receptors. | A(1) and A(3) adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes.
Gessi S, Merighi S, Stefanelli A, Fazzi D, Varani K, Borea PA. | 04/19/2014 |
| data show that inosine acting on A2A or A3 adenosine receptors can regulate OVA-induced allergic lung inflammation | Anti-inflammatory effects of inosine in allergic lung inflammation in mice: evidence for the participation of adenosine A2A and A 3 receptors.
da Rocha Lapa F, de Oliveira AP, Accetturi BG, de Oliveira Martins I, Domingos HV, de Almeida Cabrini D, de Lima WT, Santos AR., Free PMC Article | 03/22/2014 |
| A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses. | Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo.
Butler M, Sanmugalingam D, Burton VJ, Wilson T, Pearson R, Watson RP, Smith P, Parkinson SJ. | 02/16/2013 |
| A3AR induces reactive oxygen species generation, possibly through activation of Nox2, with subsequent contraction of the mouse aorta. | NADPH oxidase pathway is involved in aortic contraction induced by A3 adenosine receptor in mice.
El-Awady MS, Ansari HR, Fil D, Tilley SL, Mustafa SJ., Free PMC Article | 10/1/2011 |
| A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation. | A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation.
Inoue Y, Tanaka H, Sumi Y, Woehrle T, Chen Y, Hirsh MI, Junger WG., Free PMC Article | 04/30/2011 |
| Activation of A(1)R or A(3)R by CCPA or Cl-IB-MECA, respectively, protects cardiomyocytes from hypoxia via phosphorylation of p38 MAPK, which is located downstream from the mitochondrial K(ATP) channel opening | Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.
Leshem-Lev D, Hochhauser E, Chanyshev B, Isak A, Shainberg A. | 03/26/2011 |
| testicular mouse A3Ri2 and human A3Ri3 adenosine receptors have roles in sperm function | Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm.
Burnett LA, Blais EM, Unadkat JD, Hille B, Tilley SL, Babcock DF., Free PMC Article | 11/27/2010 |
| Data show that mice lacking adenosine A(3) receptors exhibit a surprisingly clear phenotype with changes in diurnal rhythm and temperature regulation. | Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.
Yang JN, Wang Y, Garcia-Roves PM, Björnholm M, Fredholm BB., Free PMC Article | 09/20/2010 |
| Hematopoietic precursor cells expressed Adora3 mrna. | Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 1. Expression of receptor mRNA in four mouse hematopoietic precursor cells.
Štreitová D, Sefc L, Savvulidi F, Pospíšil M, Holá J, Hofer M. | 08/30/2010 |