| Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis. | Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis.
Hu Y, Gu X, Zhang Y, Ma W, Sun L, Wang C, Ren B. | 02/22/2024 |
| Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice. | Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice.
Shrestha AK, Menon RT, Yallampalli C, Barrios R, Shivanna B., Free PMC Article | 12/11/2021 |
| Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ss-Smads Signaling and Myofibroblast Differentiation. | Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ß-Smads Signaling and Myofibroblast Differentiation.
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T. | 10/23/2021 |
| Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. | Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T. | 11/28/2020 |
| Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System. | Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System.
Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T. | 10/26/2019 |
| Adrenomedullin is an endogenous, epicardial-derived factor that drives reparative cardiac lymphangiogenesis and function via Cx43, and this represents a new therapeutic pathway for improving myocardial edema after injury. | Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43.
Trincot CE, Xu W, Zhang H, Kulikauskas MR, Caranasos TG, Jensen BC, Sabine A, Petrova TV, Caron KM., Free PMC Article | 10/26/2019 |
| A novel gene targeting approach was presented in which PAMP (proadrenomedullin N-terminal 20 peptide) is deleted exclusively, while retaining the coding sequence for AM (adrenomedullin) peptide, and demonstrate that mice lacking PAMP are viable and fertile. | Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.
Matson BC, Li M, Trincot CE, Blakeney ES, Pierce SL, Caron KM., Free PMC Article | 08/31/2019 |
| Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans. | Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction.
Hinrichs S, Scherschel K, Krüger S, Neumann JT, Schwarzl M, Yan I, Warnke S, Ojeda FM, Zeller T, Karakas M, Keller T, Meyer C, Blankenberg S, Westermann D, Lindner D., Free PMC Article | 10/20/2018 |
| AM is an important regulator of endothelial cell function, angiogenesis, tumorigenesis, and brain response to ischemia. | Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage.
Ochoa-Callejero L, Pozo-Rodrigálvarez A, Martínez-Murillo R, Martínez A., Free PMC Article | 06/9/2018 |
| The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases. | Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T. | 10/14/2017 |
| Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. | Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves.
Pfeil U, Bharathala S, Murtaza G, Mermer P, Papadakis T, Boening A, Kummer W. | 05/27/2017 |
| Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages. | Adrenomedullin Regulates IL-1β Gene Expression in F4/80+ Macrophages during Synovial Inflammation.
Takano S, Uchida K, Miyagi M, Inoue G, Aikawa J, Iwabuchi K, Takaso M., Free PMC Article | 04/8/2017 |
| the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery. | Adrenomedullin regulates club cell recovery following lung epithelial injury.
García-Sanmartín J, Larrayoz IM, Martínez A. | 01/28/2017 |
| vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin | Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration.
Siemsen DW, Dobrinen E, Han S, Chiocchi K, Meissner N, Swain SD., Free PMC Article | 06/28/2016 |
| It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility. | Adrenomedullin increases the short-circuit current in the mouse seminal vesicle: actions on chloride secretion.
Liao SB, Cheung KH, O WS, Tang F. | 05/14/2016 |
| Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice. | Cohort of estrogen-induced microRNAs regulate adrenomedullin expression.
Wetzel-Strong SE, Li M, Espenschied ST, Caron KM., Free PMC Article | 05/7/2016 |
| These results indicate the AM-RAMP2 system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth. | Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia.
Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Koyama T, Uetake R, Ihara M, Shindo T. | 08/1/2015 |
| Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. | Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
Wetzel-Strong SE, Li M, Klein KR, Nishikimi T, Caron KM., Free PMC Article | 09/20/2014 |
| It is a vasodiation factor and a essential factor for angiogenesis. | [Pathophysiological roles of adrenomedullin and its receptor activity modifying system].
Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Koyama T. | 08/23/2014 |
| The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase probably by suppressing the local renin-angiotensin system. | The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice.
Hayashi M, Tojo A, Shimosawa T, Fujita T., Free PMC Article | 02/1/2014 |
| Hypoxia upregulates expression of the Notch ligand Dll4 and increases Notch signaling in a process requiring the vasoactive hormone adrenomedullin. | Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling.
Lanner F, Lee KL, Ortega GC, Sohl M, Li X, Jin S, Hansson EM, Claesson-Welsh L, Poellinger L, Lendahl U, Farnebo F. | 11/16/2013 |
| Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis. | Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis.
Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T. | 11/16/2013 |
| ADM signaling is involved in laser-induced CNV formation, because both an ADM antagonist and ADM mAb significantly inhibited it. | An angiogenic role for adrenomedullin in choroidal neovascularization.
Sakimoto S, Kidoya H, Kamei M, Naito H, Yamakawa D, Sakaguchi H, Wakabayashi T, Nishida K, Takakura N., Free PMC Article | 09/14/2013 |
| Endogenous adrenomedullin is a key factor in secondary lymphedema pathogenesis and provides experimental in vivo evidence of an underlying germ-line genetic predisposition to developing this disorder. | Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.
Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MC, Fujita T, Boshoff C., Free PMC Article | 09/7/2013 |
| Fetal adrenomedullin, acting through calcitonin receptor-like receptor, serves as a trophoblast-derived factor critical for fetal placental vascularization. | Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta.
Li M, Schwerbrock NM, Lenhart PM, Fritz-Six KL, Kadmiel M, Christine KS, Kraus DM, Espenschied ST, Willcockson HH, Mack CP, Caron KM., Free PMC Article | 08/3/2013 |