| GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14. | GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14.
Liu Q, Jiao L, Ye MS, Ma Z, Yu J, Su LY, Zou WY, Yang LX, Chen C, Yao YG., | 06/7/2024 |
| Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation. | Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
Tang X, Zhao S, Liu J, Liu X, Sha X, Huang C, Hu L, Sun S, Gao Y, Chen H, Zhang Z, Wang D, Gu Y, Chen S, Wang L, Gu A, Chen F, Pu J, Chen X, Yu B, Xie L, Huang Z, Han Y, Ji Y. | 10/26/2023 |
| Class III Alcohol Dehydrogenase Plays a Key Role in the Onset of Alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice. | Class III Alcohol Dehydrogenase Plays a Key Role in the Onset of Alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice.
Haseba T, Maruyama M, Akimoto T, Yamamoto I, Katsuyama M, Okuda T., Free PMC Article | 08/19/2023 |
| S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia. | S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.
Kulandavelu S, Dulce RA, Murray CI, Bellio MA, Fritsch J, Kanashiro-Takeuchi R, Arora H, Paulino E, Soetkamp D, Balkan W, Van Eyk JE, Hare JM., Free PMC Article | 04/16/2022 |
| ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. | ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue.
Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, Li W, Zingman LV, Liu L, Lira VA, Potthoff MJ, Bartelt A, Yang L., Free PMC Article | 02/19/2022 |
| GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. | GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation.
Liu Q, Gu T, Su LY, Jiao L, Qiao X, Xu M, Xie T, Yang LX, Yu D, Xu L, Chen C, Yao YG., Free PMC Article | 12/18/2021 |
| Data show that aldo-keto reductase family 1 member A1 (AKR1A1) deletion from murine tissues dramatically lowered NADH-dependent GSNOR activity.. | AKR1A1 is a novel mammalian S-nitroso-glutathione reductase.
Stomberski CT, Anand P, Venetos NM, Hausladen A, Zhou HL, Premont RT, Stamler JS., Free PMC Article | 06/27/2020 |
| nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis in humans and mice. | nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis.
Montagna C, Rizza S, Cirotti C, Maiani E, Muscaritoli M, Musarò A, Carrí MT, Ferraro E, Cecconi F, Filomeni G., Free PMC Article | 05/16/2020 |
| Our data indicates that nebivolol has no effect on GSNOR activity, nor does nebivolol inhibit thioredoxin reductase, two of the major protein denitrosylases. | Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties.
Barnett SD, Buxton ILO., Free PMC Article | 11/2/2019 |
| Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis. | GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.
Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X, Han L, Deng J, Fan F, Liu B, Huo Y, Xu Q, Chen C, Wang X, Feng J., Free PMC Article | 10/27/2018 |
| Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy. | S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy.
Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L., Free PMC Article | 05/26/2018 |
| Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione. | Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.
Jiang H, Polhemus DJ, Islam KN, Torregrossa AC, Li Z, Potts A, Lefer DJ, Bryan NS. | 11/11/2017 |
| Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation. | Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα.
Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L, Chen C., Free PMC Article | 10/14/2017 |
| These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes. | S-Nitrosoglutathione Reductase Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria.
Elphinstone RE, Besla R, Shikatani EA, Lu Z, Hausladen A, Davies M, Robbins CS, Husain M, Stamler JS, Kain KC., Free PMC Article | 09/9/2017 |
| GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance. | GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
Moon Y, Cao Y, Zhu J, Xu Y, Balkan W, Buys ES, Diaz F, Kerrick WG, Hare JM, Percival JM., Free PMC Article | 08/12/2017 |
| Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells. | S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction.
Hatzistergos KE, Paulino EC, Dulce RA, Takeuchi LM, Bellio MA, Kulandavelu S, Cao Y, Balkan W, Kanashiro-Takeuchi RM, Hare JM., Free PMC Article | 04/23/2016 |
| Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage. | Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.
Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ., Free PMC Article | 01/16/2016 |
| S-nitrosoglutathione reductase-dependent modification of PPARgamma alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages. | S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis.
Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM., Free PMC Article | 07/4/2015 |
| These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states. | S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
Montagna C, Di Giacomo G, Rizza S, Cardaci S, Ferraro E, Grumati P, De Zio D, Maiani E, Muscoli C, Lauro F, Ilari S, Bernardini S, Cannata S, Gargioli C, Ciriolo MR, Cecconi F, Bonaldo P, Filomeni G., Free PMC Article | 02/21/2015 |
| Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2). | A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
Wu K, Ren R, Su W, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte JC, Liu GH, Chen C., Free PMC Article | 10/11/2014 |
| GSNOR appears to play a crucial role in controlling pulmonary and systemic infection by K. pneumoniae. | Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice.
Tang CH, Seeley EJ, Huang X, Wolters PJ, Liu L., Free PMC Article | 04/26/2014 |
| A critical role for GSNOR in maintaining genomic integrity. | S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver.
Leung J, Wei W, Liu L., Free PMC Article | 10/19/2013 |
| This study suggests that S-nitrosoglutathione reductase degradation of S-nitrosoglutathione is a vital step in the expression of ventilatory roll-off | Ventilatory responses during and following exposure to a hypoxic challenge in conscious mice deficient or null in S-nitrosoglutathione reductase.
Palmer LA, May WJ, deRonde K, Brown-Steinke K, Bates JN, Gaston B, Lewis SJ., Free PMC Article | 08/10/2013 |
| GSNOR deficiency has a role in hepatocarcinogenesis, which is prevented by iNOS inhibition | Hepatocarcinogenesis driven by GSNOR deficiency is prevented by iNOS inhibition.
Tang CH, Wei W, Hanes MA, Liu L., Free PMC Article | 06/29/2013 |
| Increasing the denitrosylation capacity of cardiomyocytes, via cardiomyocyte-specific overexpression of GSNOR, protects against sepsis-induced myocardial depression. | Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F., Free PMC Article | 06/8/2013 |