| Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. | Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q, Lu Z, Xu D. | 05/17/2023 |
| CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. | CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.
Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, Ittmann MM, Gleave ME, Li W., Free PMC Article | 02/12/2022 |
| Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer. | Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer.
Okubo K, Arigami T, Matsushita D, Kijima T, Shimonosono M, Uenosono Y, Yanagita S, Kurahara H, Mori S, Ohtsuka T, Natsugoe S., Free PMC Article | 05/15/2021 |
| Creatine kinase B controls futile creatine cycling in thermogenic fat. | Creatine kinase B controls futile creatine cycling in thermogenic fat.
Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L., Free PMC Article | 03/20/2021 |
| The data revealed a varying but significant increase of CK activity in CKBE individuals as compared to controls, reaching an almost 800-fold increase in two CKBE individuals which also had increased erythrocyte creatine. | Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform.
Kay L, Tokarska-Schlattner M, Quenot-Carrias B, Goudet B, Bugert P, Arnold H, Scheuerbrandt G, Schlattner U. | 08/18/2018 |
| Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress. | Prx II and CKBB proteins interaction under physiologic al and thermal stress conditions in A549 and HeLa cells.
Rakhmetov AD, Pil LS, Ostapchenko LI, Zoon CH. | 01/20/2018 |
| membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. | Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites.
Schlattner U, Klaus A, Ramirez Rios S, Guzun R, Kay L, Tokarska-Schlattner M. | 12/16/2017 |
| These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo. | Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
Zervou S, Whittington HJ, Ostrowski PJ, Cao F, Tyler J, Lake HA, Neubauer S, Lygate CA., Free PMC Article | 10/14/2017 |
| SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression. | Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis.
Mello AA, Leal MF, Rey JA, Pinto GR, Lamarão LM, Montenegro RC, Alves AP, Assumpção PP, Borges Bdo N, Smith MC, Burbano RR., Free PMC Article | 06/11/2016 |
| CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups. | Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP.
Yıldız K, Ince AT, Sarbay Kemik A, Sert S, Isen HC, Tozlu M, Baysal B, Akyüz U, Kocaman O, Danalıoğlu A. | 09/10/2015 |
| CK-B catalytic activity also helps in the formation of protrusive ruffle structures which are actin-dependent and abundant on the surface of both unstimulated and LPS-activated macrophages. | Submembranous recruitment of creatine kinase B supports formation of dynamic actin-based protrusions of macrophages and relies on its C-terminal flexible loop.
Venter G, Polling S, Pluk H, Venselaar H, Wijers M, Willemse M, Fransen JA, Wieringa B. | 08/29/2015 |
| increased serum Ckbb reflects failure of osteoclasts or suppression of osteoclasts in children with osteogenesis imperfecta during neridronate treatment | Serum brain-type creatine kinase increases in children with osteogenesis imperfecta during neridronate treatment.
D'Eufemia P, Finocchiaro R, Villani C, Zambrano A, Lodato V, Palombaro M, Properzi E, Celli M. | 12/20/2014 |
| Estimation of CK and its CK isoenzyme fractions can aid in quick and accurate diagnosis of tubal ectopic pregnancy. | Diagnostic significance of total creatine kinase and its isoform in tubal ectopic pregnancy.
Soundravally R, Krishna Latha T, Soundara Raghavan S, Ananthanarayanan PH, Srilatha K. | 07/19/2014 |
| effects of osmolytes on human brain-type creatine kinase folding | Effects of osmolytes on human brain-type creatine kinase folding in dilute solutions and crowding systems.
Fan YQ, Lee J, Oh S, Liu HJ, Li C, Luan YS, Yang JM, Zhou HM, Lü ZR, Wang YL. | 03/1/2014 |
| We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. | Anti-retinal antibodies in patients with macular telangiectasia type 2.
Zhu L, Shen W, Zhu M, Coorey NJ, Nguyen AP, Barthelmes D, Gillies MC. | 11/2/2013 |
| analysis of SNPs and their effect on creatine kinase structure and function | Effect of SNPs on creatine kinase structure and function: identifying potential molecular mechanisms for possible creatine kinase deficiency diseases.
Li C, Zhang Q, Hu WJ, Mu H, Lin Z, Ma L, Park YD, Zhou HM., Free PMC Article | 05/11/2013 |
| study found promoter SNPs of CKB and TPI1 were weakly associated with schizophrenia;in addition, IFNG polymorphisms were associated with schizophrenia; results suggest that IFNG and proteins affected by IFNG may play a role in the pathogenesis of schizophrenia | Roles of interferon-gamma and its target genes in schizophrenia: Proteomics-based reverse genetics from mouse to human.
Kim HJ, Eom CY, Kwon J, Joo J, Lee S, Nah SS, Kim IC, Jang IS, Chung YH, Kim SI, Chung JH, Choi JS. | 12/22/2012 |
| de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow | High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
Arnold H, Wienker TF, Hoffmann MM, Scheuerbrandt G, Kemp K, Bugert P. | 11/3/2012 |
| His103 and Phe107 in hASB9-2 are essential for binding to CKB. | Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
Fei X, Gu X, Fan S, Yang Z, Li F, Zhang C, Gong W, Mao Y, Ji C. | 08/18/2012 |
| Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells. | Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K. | 04/28/2012 |
| The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding. | Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
Wang Y, Wang S, Gao YS, Chen Z, Zhou HM, Yan YB., Free PMC Article | 03/3/2012 |
| Data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT. | Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.
Mooney SM, Rajagopalan K, Williams BH, Zeng Y, Christudass CS, Li Y, Yin B, Kulkarni P, Getzenberg RH., Free PMC Article | 08/6/2011 |
| CKB was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality | Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells.
Lee MS, Liu CH, Lee TH, Wu HM, Huang CC, Huang LS, Chen CM, Cheng EH., Free PMC Article | 06/4/2011 |
| These observations suggested that the ability to generate the oxidized form could protect BBCK against the intracellular oxidative stress. | Generation of the oxidized form protects human brain type creatine kinase against cystine-induced inactivation.
Li XH, Chen Z, Gao YS, Yan YB, Zhang F, Meng FG, Zhou HM. | 06/4/2011 |
| Report the effects of prior calcium channel blocker therapy on creatine kinase-MB (myocardial form) levels after percutaneous coronary interventions. | The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions.
Gulmez O, Atar I, Ozin B, Korkmaz ME, Atar A, Aydinalp A, Yildirir A, Muderrisoglu H., Free PMC Article | 10/25/2010 |